Objectives: Determination of the best diagnostic methods for ectopic pregnancy (EP) and threatened abortion is an issue of importance specially to improve the final prognosis. The purpose was to determine the CA-125 level in cases of EP and threatened abortion in comparison with control subjects.
Methods: In this cross-sectional study,90 consecutive women attending to Shohada-e-Tajrish and Mahdieh Hospitals in Tehran including those with EP and threatened abortion and control subjects were enrolled and CA-125 level was determined and compared across the three groups.
Results: The results in this study demonstrated that CA-125 level was significantly different across the groups (P=0.005) and in paired comparisons it was higher in threatened abortion cases versus control subjects (P=0.003) but it was not significantly differed between the other groups (P > 0.05).
Conclusion: Totally, according to the obtained results it may be concluded that serum CA-125 level is higher in threatened abortion cases but not significantly in EP cases. Hence use of this method is recommended in clinical setting for threatened abortion.
Rausch ME, Barnhart KT. Serum biomarkers for detecting ectopic pregnancy. Clin Obstet Gynecol. 2012;55(2):418-23.
Belics Z, Gérecz B, Csákány MG. [Early diagnosis of ectopic pregnancy]. Orv Hetil. 2014;155(29):1158-66.
Koonin LM, MacKay AP, Berg CJ, Atrash HK, Smith JC. Pregnancy-related mortality surveillance--United States, 1987-1990. MMWR CDC Surveill Summ. 1997;46(4):17-36.
Madendag Y, Col-Madendag I, Kanat-Pektas M, Danisman N. Predictive power of serum CA-125 and LDH in the outcome of first trimester pregnancies with human chorionic gonadotropin levels below discriminatory zone. Arch Gynecol Obstet. 2009;279(5):661-6.
Pisarska MD, Carson SA, Buster JE. Ectopic pregnancy. Lancet. 1998;351(9109):1115-20.
Marion LL, Meeks GR. Ectopic pregnancy: History, incidence, epidemiology, and risk factors. Clin Obstet Gynecol. 2012;55(2):376-86.
Bonassi S, Neri M, Puntoni R. Validation of biomarkers as early predictors of disease. Mutat Res. 2001;480-481:349-58.
Katsikis I, Rousso D, Farmakiotis D, Kourtis A, Diamanti-Kandarakis E, Panidis D. Receiver operator characteristics and diagnostic value of progesterone and CA-125 in the prediction of ectopic and abortive intrauterine gestations. Eur J Obstet Gynecol Reprod Biol. 2006;125(2):226-32.
Schmidt T, Rein DT, Foth D, Eibach HW, Kurbacher CM, Mallmann P, et al. Prognostic value of repeated serum CA 125 measurements in first trimester pregnancy. Eur J Obstet Gynecol Reprod Biol. 2001;97(2):168-73.
Condous G, Kirk E, Syed A, Van Calster B, Van Huffel S, Timmerman D, et al. Do levels of serum cancer antigen 125 and creatine kinase predict the outcome in pregnancies of unknown location? Hum Reprod. 2005;20(12):3348-54.
Butler SA, Abban TK, Borrelli PT, Luttoo JM, Kemp B, Iles RK. Single point biochemical measurement algorithm for early diagnosis of ectopic pregnancy. Clin Biochem. 2013;46(13-14):1257-63.
Fiegler P, Kamiński K, Wegrzyn P. [Serum levels of CA-125 antigen during the first trimester of pregnancy complications and the risk of miscarriage]. Ginekol Pol. 2003;74(5):345-9.
Predanic M. Differentiating tubal abortion from viable ectopic pregnancy with serum CA-125 and beta-human chorionic gonadotropin determinations. Fertil Steril. 2000;73(3):522-5.
Abdul-Hussein MM, Abdul-Rasheed OF, Al-Moayed HA. The Values of CA-125, Progesterone, ß-HCG and Estradiol in the Early Prediction of Ectopic Pregnancy. Oman Med J. 2012;27(2):124-8.
Hornstein MD, Check JH, Hill JA. Serum CA 125 levels and spontaneous abortion. Am J Obstet Gynecol. 1995;172(2 Pt 1):695-9.