The Trends in Peptide and Protein Sciences is a peer-reviewed, online-only (previously print-online), scientific journal owned by Protein Technology Research Center, Shahid Beheshti University of Medical Sciences and documents in all important aspects of the research in peptides and proteins focusing on analytics and impurities, bioinformatics, biopharmaceuticals and vaccines, biotechnology, chemical synthesis, conformational analysis, design and  development of protein therapeutics, determination of structure, enzymology, folding and sequencing,  formulation and stability, function, genetics,  immunology, kinetics, modeling, molecular biology, pharmacokinetics and pharmacodynamics of therapeutic proteins and antibodies, pharmacology,  protein engineering and development, protein-protein interaction, proteomics, purification/expression/production, simulation, thermodynamics and  hydrodynamics and protein biomarkers. The aim of this Journal is to publish high quality original research articles, reviews, short communications and letters and to provide a medium for scientists and researchers to share their findings from the area of peptides and proteins. The Trends in Peptide and Protein Sciences is published in collaboration with Iranian Association of Pharmaceutical Scientists.



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Journal Info

Editor-in-Chief: Bahram Kazemi, PhD


pISSN: 2538-2535
eISSN: 2538-2446


Call for Papers: Electronic Volume 5 (2020)

Dear Researcher/Scientist We are pleased to invite your manuscript submissions to the electronic volume 5 (2020) of Trends in Peptide and Protein Sciences (TPPS). Based on the new TPPS publication policies, articles will be continuously published online only from 2018 . ...

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Identification of Proteins Participating in the Cisplatin Resistance Following Treatment with Cisplatin in A2780 and A2780CP Ovarian Cell Lines

Kamyar Keshavarz Farajkhah, Maryam Tabarzad, Farshad Hosseini Shirazi, Mohammad Hassan Houshdar Tehrani

Trends in Peptide and Protein Sciences, Vol. 5 (2020), 4 March 2020 , Page 1-6

Ovarian cancer is the most fatal gynecological cancer and the 8th most prevalent type of cancer in Iran. Chemotherapy regimen for the treatment of this type of cancer is mostly based on platinum agents and paclitaxel. The major problem during treatment with cisplatin is the appearance of acquired resistance in cancer cells in the first 6 months of therapy. Owing to inefficacy of second line regimens, it seems necessary to find out the molecular mechanisms of cisplatin resistance and find an efficient strategy against the resistant cancer cells. In this study, two ovarian cancer cell lines, A2780-sensitive and A2780CP (resistant to cisplatin) were evaluated. To acquire the protein expression profile, a culture of each line containing 1.5×107 cells was divided into the two groups of control and treatment cells. The treatment group cells were treated with cisplatin at pre-determined IC50 concentration for 6 hours. Then, the total proteins of 7×106 cells were extracted. The proteome of each group (20 μg) was used for subsequent separation of proteins by two-dimensional gel electrophoresis using 7 cm IPG strips. The results of protein pattern changes were analyzed by one-way ANOVA. At least 230 proteins were detected in each gel, from which, about 45 proteins were differentially expressed in each model of comparison. However, by considering the results of all models of analysis on the protein expression profile of two cell lines, three proteins were determined as the key players of resistance against cisplatin. Our results can be considered in the therapeutic regimen of ovarian cancers with cisplatin as important knowledge for defending against resistant cancer cells.


  • The major problem during treatment with cisplatin is the appearance of acquired resistance in cancer cells.
  • The cisplatin- resistant and sensitive ovarian cell lines of A2780 were evaluated in this study.
  • Proteomics analysis was run using 2D gel electrophoresis after cisplatin treatment.
  • Three proteins were determined as the key players of resistance against cisplatin in A2780 cell line.

Effect of High Salinity on Mycosporine-Like Amino Acid Production in Desmodesmus sp.

Rouzbeh Gharib, Maryam Tabarzad, Tahereh Hosseinabadi

Trends in Peptide and Protein Sciences, Vol. 5 (2020), 4 March 2020 , Page 1-6

Mycosporine like amino acids (MAAs) are UV absorbing compounds which are produced by a variety of organisms such as algae and cyanobacteria, in order to protect themselves from harmful UV irradiation. Thus, they can potentially be used as sunscreens in pharmaceutical and cosmetic industry. Many abiotic factors are studied which induce the production of MAAs in algae and cyanobacteria. In this investigation, we have cultivated the green microalga Desmodesmus sp. under salt stress and studied the effect of high salinity on MAAs biosynthesis. MAAs was extracted and partially purified using HPLC method. One compound with similar properties to MAAs was detected from the biomass extract, having a maximum absorption at 320 nm. Accordingly, this genus of microalgae can produce MAA-like compound under this condition, whereas it was not capable to synthesize MAA in normal condition. In fact, salinity is a stressor which can lead to the induction of MAAs synthesis in this microalga. Moreover, this investigation supports that the production of MAAs in microalgae helps the organism to survive in harsh environments, such as high salinity conditions.


  • Mycosporine like amino acids (MAAs) can be considered as valuable sunscreens.
  • High salinity condition can induce MAAs production.
  • Desmodesmus sp. in high salinity medium can produce MAA compound.