Effect of PLGA-IB on ICAM-1 and VCAM-1 expression in a mice adhesion model
Novelty in Biomedicine,
Vol. 4 No. 3 (2016),
3 July 2016
AbstractBackground: In this study, we compared the effect of ibuprofen (IB) while incorporating by Poly Lactic-co-Glycolic Acid (PLGA) nanofiber on expression of adhesion molecules ICAM-1 and VCAM-1 in a mice adhesion model.
Materials and Methods: Using an adhesion model were induced in mice, PLGA-IB and PLGA membranes and IB were sutured between the abdominal wall and peritoneum after surgical operation to reveal the best membrane for prevention of postoperative adhesion bands by comparison of ICAM-1 and VCAM-1 expression.
Results: Compared with other groups, PLGA-IB showed a greater ability to reduce ICAM-1 and VCAM-1 expression.
Conclusion: These results suggested that in considering the FDA approved polymers, PLGA-IB could be introduced as a potential candidate for prevention of abdominal post-surgery inflammation and adhesion band formation after surgeries.
- Intraperitoneal adhesion
Campeau JD. Peritoneal repair and post-surgical adhesion formation. Human Reproduction Update. 2001;7:547-55.
Greene AK. Puder M. Prevention of intra-abdominal adhesions using the antiangiogenic COX-2 inhibitor celecoxib. Annals of surgery. 2006;244-328.
Hwang K, Bianchi E, Sigman M, Lamb D, Boekelheide K. Special research presentation: defining the role of ghrelin in wound healing and the inflammatory response in the post-operative setting. Fertility and Sterility. 2014;102-4.
Van der J, Jeekel J. Biology of the peritoneum in normal homeostasis and after surgical trauma. Colorectal Disease. 2007;9:9-13.
Hanada T, Yoshimura A. Regulation of cytokine signaling and inflammation. Cytokine & growth factor reviews. 2002;13:413-21.
van Eijck FC, Wijnen RM, van Goor H. The incidence and morbidity of adhesions after treatment of neonates with gastroschisis and omphalocele: a 30-year review. Journal of pediatric surgery. 2008;43:479-83.
Zalcman M, Sy M, Donckier V, Closset J, Gansbeke DV. Helical CT signs in the diagnosis of intestinal ischemia in small-bowel obstruction. American journal of roentgenology. 2000;175:1601-7.
Dinarvand P, Hashemi SM, Seyedjafari E, Shabani I, Mohammadi-Sangcheshmeh A, Farhadian S, Soleimani M. Function of poly (lactic-co-glycolic acid) nanofiber in reduction of adhesion bands. Journal of Surgical Research. 2012;172:1-9.
Kamel RM. Prevention of postoperative peritoneal adhesions. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2010;150:111-8.
Asran, A. S.; Razghandi, K.; Aggarwal, N.; Michler, G. H.; Groth, T. Nanofibers from blends of polyvinyl alcohol and polyhydroxy butyrate as potential scaffold material for tissue engineering of skin. Biomacromolecules 2010, 11, 3413-3421.
Ding B, Wang M, Wang X, Yu J, Sun G. Electrospun nanomaterials for ultrasensitive sensors. Materials Today. 2010;13:16-27.
Zong X, Li S, Chen E, Garlick B, Kim K, Fang D, et al. Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly (lactide-co-glycolide)-based membranes. Annals of surgery. 2004;240, 910.
Seyedjafari E, Soleimani M, Ghaemi N, Shabani I. Nanohydroxyapatite-coated electrospun poly (l-lactide) nanofibers enhance osteogenic differentiation of stem cells and induce ectopic bone formation. Biomacromolecules. 2010;11:3118-25.
Hashemi SM, Soudi S, Shabani I, Naderi M, Soleimani M. The promotion of stemness and pluripotency following feeder-free culture of embryonic stem cells on collagen-grafted 3-dimensional nanofibrous scaffold. Biomaterials. 2011;32:7363-74.
Dinarvand P, Hassanian SM, Weiler H, Rezaie AR. Intraperitoneal administration of activated protein C prevents postsurgical adhesion band formation. Blood. 2015;125:1339-48.
Chen SH, Chen CH, Fong YT, Chen JP. Prevention of peritendinous adhesions with electrospun chitosan-grafted polycaprolactone nanofibrous membranes. Acta biomaterialia. 2014;10:4971-82.
Bölgen N, Vargel I, Korkusuz P, Menceloğlu YZ, Pişkin E. In vivo performance of antibiotic embedded electrospun PCL membranes for prevention of abdominal adhesions. Journal of Biomedical Materials Research Part B: Applied Biomaterials. 2007;81:530-43.
Attard JA, MacLean AR. Adhesive small bowel obstruction: epidemiology, biology and prevention. Canadian Journal of Surgery. 2007;50:291.
Kim I, Moon SO, Kim SH, Kim HJ, Koh YS, Koh GY. Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-κB activation in endothelial cells. Journal of Biological Chemistry. 2001;276:7614-20.
Tak PP, Firestein GS. NF-κB: a key role in inflammatory diseases. Journal of clinical investigation. 2001;107:7.
- Abstract Viewed: 491 times
- PDF Downloaded: 318 times