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Breast ductal carcinoma metastasis to jaw bones: a case report

Mahmood Reza AshabYamin, Abdoljalil Kalantarhormozi, Fariba Hamdamjo, Zahra Razi





Malignant tumors of the oral cavity which are metastatic are very rare and consist of 1% of malignancies of the oral cavity. Numbness or paresthesia of the lower lip or the chin is the main feature of presence of metastasis in the jaw. Our patient was a 38 year old woman with chief complaint of pain in the right half of her face, jaw and teeth. Her medical history revealed a radical mastectomy with lymphadenectomy in the left breast because of invasive ductal carcinoma grade II/III and stage IIIA (T2N2M0) without distant metastasis, followed by chemotherapy (before and after the surgery) and radiotherapy two years ago. Following complementary examinations a malignant bone lesion in particular osteosarcoma was suspected. According to this evidence, possibility of early diagnosis of malignant tumors is very important for dentists and maxillofacial surgeons. Symptoms such as paresthesia of the lip and chin is very helpful in differential diagnosis of metastatic lesions from other similar clinical cases especially in patients with history of malignancies which minimize surgical and mental injuries and increase life expectancy of patients.


breast cancer, metastatic tumors, numb chin syndrome


Dib LL, Soares AL, Sandoval RL, Nannmark U. Breast metastasis around dental implants: a case report. Clin Implant Dent Relat Res 2007;9(2):112-5.

Doykos JD. Wilms' tumor metastatic to mandible and oral mucosa: Report of a case. Oral Surg Oral Med Oral Pathol. 1969;27(2):220-4.

Sutton D, Grainger R. Textbook of Radiology Churchill Livingstone. Edinburgh, London. 1975:395-7.

Weber AL, Kaneda T, Scrivani SJ, Aziz S. Jaw: cysts, tumors, and nontumorous lesions. Head and neck imaging, 4th ed St Louis, MO: Mosby. 2003:930-94.

Hirshberg A, Leibovich P, Buchner A. Metastatic tumors to the jawbones: analysis of 390 cases. J Oral Pathol Med. 2006;23(8):337-41.

D’Silva NJ, Summerlin D-J, CordellKG, Abdelsayed RA, Tomich CE, Hanks CT, et al. Metastatic tumors in the jaws A retrospective study of 114 cases. J Am Dent Assoc. 2006;137(12):1667-72.

Van der Waal R, Buter J, Van der Waal I. Oral metastases: report of 24 cases. Br J Oral Maxillofac Surg. 2003;41(1):3-6.

Akinbami B. Metastatic carcinoma of the jaws: a review of literature. Niger J Med. 2009;18(2):139-42.

FRIEDRICH RE, ABADI M. Distant metastases and malignant cellular neoplasms encountered in the oral and maxillofacial region: analysis of 92 patients treated at a single institution. Anticancer Res. 2010;30(5):1843-8.

Ryba F, Rice S, Hutchison I. Numb chin syndrome: an ominous clinical sign. Br Dent J. 2010;208(7):283-5.

Boyczuk E, Solomon M, Gold B. Unremitting pain to the mandible secondary to metastatic breast cancer: a case report. Compendium. 1991;12(2):104.

Pruckmayer M, Glaser C, Marosi C, Leitha T. Mandibular pain as the leading clinicalsymptom for metastatic disease: nine cases and review of the literature. Ann Oncol. 1998;9(5):559-64.

Pharoah M, White S. Oral radiology: principles and interpretation. St. Louis, Mo.: Mosby; 2009.

Wood NK, Goaz PW. Differential diagnosisof oral and maxillofacial lesions: Mosby St. Louis; 1997.

Ögˇütcen‐Toller M, Metin M, Yıldız L. Metastatic breast carcinoma mimicking periodontal disease on radiographs. J Clin Periodontol. 2002;29(3):269-71.

Selden HS, Manhoff DT, Hatges NA, Christoph Michel R. Metastatic carcinoma to the mandible that mimicked pulpal/periodontal disease. J Endodont. 1998;24(4):267-70.

Hirshberg A, Buchner A. Metastatic tumours to the oral region. An overview. Eur J Cancer Part B: Oral Oncol. 1995;31(6):355-60.

Marx RE, Stern D. Oral and maxillofacial pathology: a rationale for diagnosis and treatment: Quintessence Carol Stream^ eIL IL; 2003.

Aniceto GS, Peñín AG, de la Mata Pages R, Montalvo Moreno JJ. Tumors metastatic to the mandible: analysis of nine cases and review of the literature. J Oral Maxillofac Surg. 1990;48(3):246-51.

Harris C, Baringer J. The numb chin in metastatic cancer. West J Med. 1991;155(5):528.

Hirshberg A, Shnaiderman-Shapiro A, Kaplan I, Berger R. Metastatic tumours to the oral cavity-pathogenesis and analysis of 673 cases. Oral Oncol. 2008;44(8):743-52.

Kurita LM. Breast adenocarcinoma mimicking temporomandibular disorders: a case report. J Contemp Dent Pract. 2008;9(5):100.

Khalili M, Mahboobi N, Shams J. Metastatic breast carcinoma initially diagnosed as pulpal/periapical disease: a case report. J Endodont. 2010;36(5):922-5.

Scipio J, Murti P, Al-Bayaty H, Matthews R, Scully C. Metastasis of breast carcinoma to mandibular gingiva. Oral Oncol. 2001;37(4):393-6.

Stavropoulos MF, Ord RA. Lobular adenocarcinoma of breast metastatic to the mandibular condyle: report of a case and review of the literature. Oral Surg Oral Med Oral Pathol. 1993;75(5):575-8.

DOI: https://doi.org/10.22037/nbm.v2i1.6108