• Logo
  • SBMUJournals

Evaluation of Measles, Rubella, Mumps, Hepatitis B and Varicella Zoster Antibodies in Medical and Dental Students in Shiraz, Iran

Afagh Moattari, Ali Ghanbari Asad, Ardalan Mansouri, Mostafa Malehi Vaziri, Farshid Moradpour Shammami





Measles, rubella, mumps, hepatitis B virus (HBV) and varicella zoster virus (VZV) cause infectious diseases that can be effectively prevented by vaccination. Vaccination of medical students is important, because they are more likely to become exposed and infected by these viruses. A total of 180 students, consisting of 90 women and 90 men, were serologically screened for measles, rubella and mumps, HBV and VZV antibodies. Their sera were examined for Immunoglobulin G (IgG) antibody against these viruses by using ELISA IgG kits. Total antibody against measles, rubella, mumps, HBV and VZV were 52%, 100%, 76%, 68% and 15% respectively. There was no significant difference in antibodies level according to gender.

The results of this study indicate vaccination is vital for medical student prior to hospital training.


Measles; Rubella; Mumps; IgG; ELISA


Domínguez PP, Costa J, Torner N, Cardenosa N, Batalla N, Plasencia A, et al. Seroprevalence of measles, rubella, and mumps antibodies in Catalonia, Spain: results of a cross-sectional study. Eur J Clin Microbiol Infect Dis. 2006; 25(5):310-7.

Alavian SM, Fallahian F, Lankarani KB. The changing epidemiology of viral hepatitis B in Iran. J Gastrointestin Liver Dis. 2007;16(4):403.

Blume S, Tump J. Evidence and policymaking: The introduction of MMR vaccine in the Netherlands. Soc Sci Med. 2010;71(6):1049-55.

Bramley JC, Jones IG. Epidemiology of chickenpox in Scotland: 1981 to. Strategies for the management of difficult to treat patients with tuberculosis. Commun Dis Public Health. 2000;3(4):282-7.

Choo PW, Donahue JG, Manson JE, Platt R. The epidemiology of varicella and its complications. J Infect Dis. 1995;172(3):706-12.

Deguen S, Chau NP, Flahault A. Epidemiology of chickenpox in France (1991-1995). J Epidemiol Commun Health (1979-). 1998:46S-9S.

Díaz-Ortega JL, Bennett JV, Castañeda D, Martinez D, Fernandez de Castro J. Antibody persistence in young adults 1 year after MMR immunization by aerosol or by subcutaneous route. Vaccine. 2010;28(44):7228-32.

Faoagali J, Darcy D. Chickenpox outbreak among the staff of a large, urban adult hospital: costs of monitoring and control. Am J Infect Control. 1995;23(4):247-50.

Gilden D, Cohrs RJ, Mahalingam R, Nagel MA. Varicella zoster virus vasculopathies: diverse clinical manifestations, laboratory features, pathogenesis, and treatment. Lancet Neurolog. 2009;8(8):731-40.

Kouadio I, Koffi A, Attoh-Toure H, Kamigaki T, Oshitani H. Outbreak of measles and rubella in refugee transit camps. Epidemiol Infect. 2009;137(11):1593.

Martin R, Deshevoi S, Buddha N, Jankovic D. Approaching measles and rubella elimination in the European Region-need to sustain the gains. Euro Surveill. 2009;14:50.

Mendelson G, Roth C, Wreghitt T, Brown N, Ziegler E, Lever A. Nosocomial transmission of measles to healthcare workers. Time for a national screening and immunization policy for NHS staff? J Hosp Infect. 2000;44(2):154.

Miller E. Measles, mumps and rubella: present and future immunisation policy. Public Health. 1988;102(4):317-21.

Perrillo RP, Eason JD. The use of HBsAg–positive organ donors: Far more than meets the eye? Liver Transpl. 2005;11(8):875-7.

Socan M, Berginc N. High seroprevalence of varicella, measles, mumps, rubella and pertussis antibodies in first-grade medical students. Wien Klin Wochenschr. 2008;120(13-14):422-6.

Torda AJ. Vaccination and screening of medical students: results of a student health initiative. Med J Aust. 2008;189(9):484.

Hamkar R, Jalilvand S, Mokhtari-Azad T, Jelyani KN, Nategh R. Evaluation of immunity against rubella in Iranian after mass campaign for measles-rubella vaccination on December 2003. Am J Infect Control. 2006;34(9):588-92.

Pourabbas B, Ziyaeyan M, Alborzi A, Mardaneh J. Efficacy of measles and rubella vaccination one year after the nationwide campaign in Shiraz, Iran. Int J Infect Dis. 2008;12(1):43-6.

Yang YF, Zhao W, Zhong YD, Xia HM, Shen L, Zhang N. Interferon therapy in chronic hepatitis B reduces progression to cirrhosis and hepatocellular carcinoma: a meta‐analysis. J Viral Hepat. 2009;16(4):265-71.

DOI: https://doi.org/10.22037/nbm.v2i1.5911