Comparison of Analgesia in Subcutaneous Infiltration of Ropivacaine and Magnesium Sulfate for Postoperative Pain Control of Cholecystectomy

Shayesteh Khorasanizadeh; Maryam Panahi; Gholamreza Mohseni; Faranak - Behnaz; Masih Ebrahymy Dehkordy; Houman Teymourian

doi:10.22037/nbm.v7i4.25686

Comparison of Analgesia in Subcutaneous Infiltration of Ropivacaine and Magnesium Sulfate for Postoperative Pain Control of Cholecystectomy

Shayesteh Khorasanizadeh, Maryam Panahi, Gholamreza Mohseni, Faranak - Behnaz, Masih Ebrahymy Dehkordy, Houman Teymourian

160

Views

PDF

Abstract

Background: The purpose of this study was to compare the effect of analgesia of Ropivacaine and magnesium sulfate as subcutaneous infiltration at the site of surgical cutaneous cholecystectomy in the postoperative period.
Materials and Methods: To achieve the research goals, 80 patients referred to Shohada Tajrish Hospital in Tehran in 2016, which were randomly divided into two groups: Ropivacaine and magnesium sulfate. Patients in both groups had similar anesthetic procedures and all of them were monitored standard were recorded within 24 hours of operation. Overall morphine dose was also recorded for postoperative pain.
Results: The findings showed that there was a significant difference between the two groups in the Ropivacaine group in the next hours despite the no significant difference in age, sex, BMI, duration of operation and pain scoring at first and third hours. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. In addition, the comparison of the number of requests for at least one dose of morphine in the Ropivacaine group is significantly lower. The occurrence of PONV is also higher in the magnesium sulfate group, but this difference is not significant.
Conclusion: Local injection of Ropivacaine reduced acute pain after open cholecystectomy surgery in comparison to local injection of magnesium sulfate. In addition, the use of Ropivacaine is associated with a significant reduction in the need for intravenous morphine for analgesia.

Keywords

Magnesium sulfate, Ropivacaine, VAS, Open cholecystectomy.

References

Abraham S, Rivero HG, Erlikh IV, Griffith LF, Kondamudi VK. Surgical and nonsurgical management of gallstones. American family physician. 2014;89(2):10-5.

Weiss AJ, Elixhauser A, Andrews RM. Characteristics of operating room procedures in US hospitals. Statistical brief. 2011;4(1):10-5.

Apfelbaum JL, Chen C, Mehta SS, Gan TJ. Postoperative pain experience: results from a national survey suggest postoperative pain continues to be undermanaged. Anesthesia & Analgesia. 2003;97(2):534-40.

Bærentzen F, Maschmann C, Jensen K, Belhage B, Hensler M, Børglum J. Ultrasound-guided nerve block for inguinal hernia repair: a randomized, controlled, double-blind study. Regional anesthesia and pain medicine. 2012;37(5):502-7.

Beaussier M, El’Ayoubi H, Schiffer E, Rollin M, Parc Y, Mazoit JX, et al. Continuous Preperitoneal Infusion of Ropivacaine Provides Effective Analgesia and Accelerates Recovery after Colorectal SurgeryA Randomized, Double-blind, Placebo-controlled Study. Anesthesiology: The Journal of the American Society of Anesthesiologists. 2007;107(3):461-8.

Demiroglu M, Ün C, Ornek DH, Kıcı O, Yıldırım AE, Horasanlı E, Dikmen B. The effect of systemic and regional use of magnesium sulfate on postoperative tramadol consumption in lumbar disc surgery. BioMed Research International. 2016;4(1):1-2.

Gan T, Habib AS, Miller TE, White W, Apfelbaum JL. Incidence, patient satisfaction, and perceptions of post-surgical pain: results from a US national survey. Current medical research and opinion. 2014;30(1):149-60.

Gibbs P, Purushotham A, Auld C, Cuschieri RJ. Continuous wound perfusion with bupivacaine for postoperative wound pain. British journal of surgery. 1988;75(9):923-4.

Kara H, Şahin N, Ulusan V, Aydoğdu T. Magnesium infusion reduces perioperative pain. European Journal of Anaesthesiology. 2002;19(1):52-6.

Kehlet H, Jensen TS, Woolf CJ. Persistent postsurgical pain: risk factors and prevention. The Lancet. 2006;367(9):1618-25.

Kehlet H, Dahl JB. Anaesthesia, surgery, and challenges in postoperative recovery. The Lancet. 2003;362(3):1921-8.

Koinig H, Wallner T, Marhofer P, Andel H, Horauf K, Mayer N. Magnesium sulfate reduces intra-and postoperative analgesic requirements. Anesthesia & Analgesia. 1998;87(1):206-10.

Kundra S, Singh RM, Singh G, Singh T, Jarewal V, Katyal S. Efficacy of magnesium sulphate as an adjunct to ropivacaine in local infiltration for postoperative pain following lower segment caesarean section. Journal of

clinical and diagnostic research: JCDR. 2016;10(4):UC18.

Kurmann A, Fischer H, Dell-Kuster S, Rosenthal R, Audigé L, Schüpfer G, et al. Effect of intraoperative infiltration with local anesthesia on the development of chronic pain after inguinal hernia repair: a randomized, triple-blinded, placebo-controlled trial. Surgery. 2015;157(1):144-54.

Burke LM, Hawley JA, Wong SH, Jeukendrup AE. Carbohydrates for training and competition. Journal of sports sciences. 2011;29(1):S17-S27.

Rawal N, Sjöstrand U, Christoffersson E, Dahlström B, Arvill A, Rydman H. Comparison of intramuscular and epidural morphine for postoperative analgesia in the grossly obese: influence on postoperative ambulation and pulmonary function. Anesthesia and analgesia. 1984;63(6):583-92.

Tzani P, Aiello M, Elia D, Boracchia L, Marangio E, Olivieri D, et al. Dynamic hyperinflation is associated with a poor cardiovascular response to exercise in COPD patients. Respiratory research. 2011;12(1):149-50.

Augestad KM, Delaney CP. Postoperative ileus: Impact of pharmacological treatment, laparoscopic surgery and enhanced recovery pathways. World journal of gastroenterology: WJG. 2010;16(17):2065-7.

Snyder GL, Greenberg S. Effect of anaesthetic technique and other perioperative factors on cancer recurrence. British journal of anaesthesia. 2010;105(2):106-15.

Lirici MM, Tierno SM, Ponzano C. Single-incision laparoscopic cholecystectomy: does it work? A systematic review. Surgical endoscopy. 2016;30(10):4389-99.

Mansour MG, Rahmani SHAGHAYEGH, Jafarabadi MINA. Local lidocaine 2% in postoperative pain management in cesarean delivery. Journal of family & reproductive health. 2015;9(1):19-21.

Donadi PK, Moningi S, Gopinath R. Comparison of bupivacaine and bupivacaine plus magnesium sulphate infiltration for postoperative analgesia in patients undergoing lumbar laminectomy: A prospective randomised double-blinded controlled study. Journal of Neuroanaesthesiology and Critical Care. 2014;1(3):180-3.

Desjardins PJ, Grossman EH, Kuss ME, Talwalker S, Dhadda S, Baum D, et al. The injectable cyclooxygenase-2-specific inhibitor parecoxib sodium has analgesic efficacy when administered preoperatively. Anesthesia & Analgesia. 2001;93(3):721-7.

DOI: https://doi.org/10.22037/nbm.v7i4.25686