• Logo
  • SBMUJournals

Prevalence of anemia and new onset atrial fibrillation in patient come to imam hossein hospital emergency department

Hadi Saberpour, Seyyed Amir Sheikholeslami, Meghdad Sedaghat, Mohammad Parsa Mahjoob




Background: Recognition of association between anemia and new onset atrial fibrillation would result in better therapeutic approaches and better prognosis. Hence, the purpose was to determine the prevalence of anemia and new onset atrial fibrillation (AF) in patient come to Imam Hossein hospital emergency department.
Materials and Methods: In the observational study that performed as a case-control survey, 150 consecutive addicted patients in imam hossein hospital emergency department in 2018 were enrolled including those with and without AF in electrocardiogram (EKG) and the frequency rate of anemia among groups was determined and compared.
Results: The results in this study demonstrated that 43 patients (27.8%) had anemia that was seen in 36% and 21.3% in case and control groups, respectively with statistically significant difference (p=0.047).
Conclusion: Totally, according to the obtained results there was significant association between anemia and new onset atrial fibrillation.


Anemia, Atrial fibrillation, Risk Factor


Lip GY, Brechin CM, Lane DA. The global burden of atrial fibrillation and stroke: a systematic review of the epidemiology of atrial fibrillation in regions outside North America and Europe. Chest. 2012 Dec;142(6):1489-98.

Go AS, Hylek EM, Phillips KA, Chang Y, Henault LE, Selby JV, et al. Prevalence of diagnosed atrial fibrillation in adults: national implications for rhythm management and stroke prevention: the AnTicoagulation and Risk Factors in Atrial Fibrillation (ATRIA) Study. JAMA. 2001 May 9;285(18):2370-5.

Wilke T, Groth A, Mueller S, Pfannkuche M, Verheyen F, Linder R, et al. Incidence and prevalence of atrial fibrillation: an analysis based on 8.3 million patients. Europace. 2013 Apr;15(4):486-93.

Naccarelli GV, Varker H, Lin J, Schulman KL. Increasing prevalence of atrial fibrillation and flutter in the United States. Am J Cardiol. 2009 Dec 1;104(11):1534-9.

Shen AY, Contreras R, Sobnosky S, Shah AI, Ichiuji AM, Jorgensen MB, et al. Racial/ethnic differences in the prevalence of atrial fibrillation among older adults--a cross-sectional study. J Natl Med Assoc. 2010 Oct;102(10):906-13.

Marini C, De Santis F, Sacco S, Russo T, Olivieri L, Totaro R, et al. Contribution of atrial fibrillation to incidence and outcome of ischemic stroke. Stroke. 2005;36(6): 1115-9.

Savelieva I, Bajpai A, John Camm A. Stroke in atrial fibrillation: update on pathophysiology, new antithrombotic therapies, and evolution of procedures and devices. Annals of medicine. 2007;39(5): 371-91.

Chobanian AV, Hill M. National heart, lung, and blood Institute Workshop on sodium and blood pressure. Hypertension. 2000;35(4): 858-63.

Rahman F, Kwan GF, Benjamin EJ. Global epidemiology of atrial fibrillation. Nature Reviews Cardiology. 2014;11(11): 639-54.

Lip GY, Pan X, Kamble S, Kawabata H, Mardekian J, Masseria C, et al. Major bleeding risk among non‐valvular atrial fibrillation patients initiated on apixaban, dabigatran, rivaroxaban or warfarin: a “real‐world” observational study in the United States. International journal of clinical practice. 2016;70(9): 752-63.

Ferrari R, Bertini M, Blomstrom-Lundqvist C, Dobrev D, Kirchhof P, Pappone C, Ravens U, Tamargo J, Tavazzi L, Vicedomini GG. An update on atrial fibrillation in 2014: from pathophysiology to treatment. International journal of cardiology. 2016 Jan 15;203:22-9.

Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D’Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ. Lifetime risk for development of atrial fibrillation. Circulation. 2004 Aug 31;110(9):1042-6.

Abdel LA, Messinger-Rapport BJ. Should nursing home residents with atrial fibrillation be anticoagulated?. Cleveland Clinic journal of medicine. 2004 Jan;71(1):40-4.

Alonso A, Krijthe BP, Aspelund T, Stepas KA, Pencina MJ, Moser CB, Sinner MF, Sotoodehnia N, Fontes JD, Janssens AC, Kronmal RA. Simple risk model predicts incidence of atrial fibrillation in a racially and geographically diverse population: the CHARGE-AF consortium. Journal of the American Heart Association. 2013 Apr 24;2(2):e000102.

Wolf PA, Abbott RD, Kannel WB. Atrial fibrillation as an independent risk factor for stroke: the Framingham Study. Stroke. 1991 Aug 1;22(8):983-8.

Fox CS, Parise H, D'Agostino Sr RB, Lloyd-Jones DM, Vasan RS, Wang TJ, Levy D, Wolf PA, Benjamin EJ. Parental atrial fibrillation as a risk factor for atrial fibrillation in offspring. Jama. 2004 Jun 16;291(23):2851-5.

Xu D, Murakoshi N, Sairenchi T, Irie F, Igarashi M,

Nogami A, Tomizawa T, Yamaguchi I, Yamagishi K, Iso H, Ota H. Anemia and reduced kidney function as risk factors for new onset of atrial fibrillation (from the Ibaraki prefectural health study). The American journal of cardiology. 2015;115(3):328-33.

McLean E, Cogswell M, Egli I, Wojdyla D, De Benoist B. Worldwide prevalence of anaemia, WHO vitamin and mineral nutrition information system, 1993-2005. Public health nutrition. 2009;12(4):444.

Sarnak MJ, Tighiouart H, Manjunath G, MacLeod B, Griffith J, Salem D, et al. Anemia as a risk factor for cardiovascular disease in The Atherosclerosis Risk in Communities (ARIC) study. Journal of the American College of Cardiology. 2002;40(1):27-33.

Groenveld HF, Januzzi JL, Damman K, van Wijngaarden J, Hillege HL, van Veldhuisen DJ, et al. Anemia and mortality in heart failure patients: a systematic review and meta-analysis. Journal of the American College of Cardiology. 2008;52(10):818-27.

Lawler PR, Filion KB, Dourian T, Atallah R, Garfinkle M, Eisenberg MJ. Anemia and mortality in acute coronary syndromes: a systematic review and meta-analysis. American heart journal. 2013;165(2):143-53.

Takabayashi K, Unoki T, Ogawa H, Esato M, Chun YH, Tsuji H, Wada H, Hasegawa K, Abe M, Akao M. Clinical characteristics of atrial fibrillation patients with anemia: from the Fushimi AF registry. European Heart Journal. 2013;34(suppl 1):P389.

Sharma S, Gage BF, Deych E, Rich MW. Anemia: an independent predictor of death and hospitalizations among elderly patients with atrial fibrillation. American heart journal. 2009;157(6):1057-63.

Lee WH, Hsu PC, Chu CY, Lee HH, Lee MK, Lee CS, et al. Anemia as an independent predictor of adverse cardiac outcomes in patients with atrial fibrillation. International journal of medical sciences. 2015;12(8):618.

Lakkireddy D. Anemia and Atrial Fibrillation. J Atr Fibrillation. 2012;4(6):804.

Ganga HV, Kolla N, Zimmerman MB, Miller WL. Impact of Chronic Anemia on the New-Onset Atrial Fibrillation in the Elderly: It May Not Be What We Have Thought. J Atr Fibrillation. 2012;4(6):515.

Xu D, Murakoshi N, Sairenchi T, Irie F, Igarashi M, Nogami A, et al. Anemia and reduced kidney function as risk factors for new onset of atrial fibrillation (from the Ibaraki prefectural health study). Am J Cardiol. 2015;115(3):328-33.

Keskin M, Ural D, Altay S, Argan O, Börklü EB, Kozan Ö. Iron deficiency and hematinic deficiencies in atrial fibrillation: A new insight into comorbidities. Turk Kardiyol Dern Ars. 2018;46(2):103-110.

Hu WS, Sung FC, Lin CL. Aplastic Anemia and Risk of Incident Atrial Fibrillation - A Nationwide Cohort Study. Circ J. 2018;82(5):1279-85.

Lin Y, He S, Feng R, Xu Z, Chen W, Huang Z, et al. Digoxin-induced anemia among patients with atrial

fibrillation and heart failure: clinical data analysis and drug-gene interaction network. Oncotarget. 2017;8(34):57003-57011.

DOI: https://doi.org/10.22037/nbm.v7i4.25317