Mesenchymal Stem Cell Injection in Two Patients Suffer From Chronic Discogenic Low Back Pain
Novelty in Biomedicine,
Vol. 8 No. 2 (2020),
14 Khordad 2020
,
Page 95-97
https://doi.org/10.22037/nbm.v7i4.24886
Abstract
Background: Discogenic low back pain is one of the leading causes of pain and disability across the world. A growing interest in the area of regenerative medicine, led by an improved understanding of the role of mesenchymal stem cells in tissue homeostasis and repair.Cases Report: We had two patients suffered from chronic discogenic low back pain. They were underwent injection of intra-discal 1.5 cc of Adipose Derived Mesenchymal Stem Cells (ADMSC) and followed up for 6 months. After this period of time, there was a significant reduction in both VAS and ODI scores in patients.
Conclusion: These data warrant further studies so that we can enhance our understanding of the other unknown mechanisms, which may exist behind stem cell injection. If the effectiveness of such injection to reduce pain and improve function is shown in the upcoming studies, it may provide a new insight for increasing this method of treatment as a proper option in the near future.- Low back pain
- Pain management
- Stem cell
How to Cite
References
Hoy D, March L, Brooks P, Blyth F, Woolf A, Bain C, Williams G, Smith E, Vos T, Barendregt J, et al. The global burden of low back pain: estimates from the Global Burden of Disease 2010 study. Ann Rheum Dis. 2014;73:968–74.
Oehme D, Goldschlager T, Ghosh P, Rosenfeld JV, Jenkin G. Cell based therapies used to treat lumbar degenerative disc disease: a systemic review of animal studies and human clinical trials. Stem Cells Int. 2015;2015:946031.
Andersson GBJ. Epidemiological features of chronic low back pain. Lancet. 1999;354(9178):581–5.
Andersson GBJ. Epidemiological features of chronic low back pain. Lancet. 1999;354(9178):581–5.
Richardson SM, Kalamegam G, Pushparaj PN, Matta C, Memic A, Khademhosseini A, et al. Mesenchymal stem cells in regenerative medicine: focus on articular cartilage and intervertebral disc degeneration. Methods. 2016;99:69–80.
Han I, Ropper AE, Konya D, Kabatas S, Toktas Z, Aljuboori Z, et al. Biological approaches to treating intervertebral disk degeneration: devising stem cell therapies. Cell Transplant. 2015;24:2197–208.
Pennicooke B, Moriquchi Y, Hussain I, Bonssar L, Hartl R. Biological treatment approaches for degenerative disc disease: a review of clinical trials and future directions. Cureus. 2016;8:e892.
Antoniou J, Steffen T, Nelson F, Winterbottom N, Hollander AP, Poole RA, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest. 1996;98:996–1003.
Martin MD, Boxell CM, Malone DG. Pathophysiology of lumbar disc degeneration: a review of the literature. Neurosurg Focus. 2002;13:E1.
Martin MD, Boxell CM, Malone DG. Pathophysiology of lumbar disc degeneration: a review of the literature. Neurosurg Focus. 2002;13:E1.
Orozco L, Soler R, Morera C, Alberca M, Sanchez A, Garcia-Sancho J. Intervertebral disc repair by autologous mesenchymal bone marrow cells: a pilot study. Transplantation. 2011;92:822–8.
Yoshikawa T, Ueda Y, Miyazaki K, Kozumi M, Takaura Y. Disc regneration therapy using marrow mesenchymal cell transplantation: a report of two case studies. Spine. 2010;35(11):E475–80.
Yoshikawa T, Ueda Y, Miyazaki K, Kozumi M, Takaura Y. Disc regneration therapy using marrow mesenchymal cell transplantation: a report of two case studies. Spine. 2010;35(11):E475–80.
Haufe SM, Mork AR. Intradiscal injection of hematopoietic stem cells in an attempt to rejuvenate the intervertebral disc. Stem Cells Dev. 2006;15(1):13.
Pettine KA, Murphy MB, Suzuki RK, Sand TT. Percutaneous injection of autologous bone marrow concentrate cells significantly reduces lumbar discogenic pain through 12 months. Stem Cells. 2015;33:146–56.
Kumar H, Ha DH, Lee EJ, Park JH, Shim JH, Ahn TK, et al. Safety and tolerability of intradiscal implantation of combined autologous adipose-derived mesenchymal stem cells and hyaluronic acid in patients with chronic discogenic low back pain: 1-year follow-up of a phase I study.Stem Cell Res Ther. 2017;8(1):262.
Ahn J, Park EM, Kim BJ, Kim JS, Choi B, Lee S-H, Han I. Transplantation of human Wharton’s jelly-derived mesenchymal stem cells highly expressing TGFβ receptors in a rabbit model of disc degeneration. Stem Cell Res Ther. 2015; 6:190.
- Abstract Viewed: 372 times
- PDF Downloaded: 197 times