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Investigation of Relative Risk Factors of Hepatitis B Virus Core Antibody Positivity among Intravenous Drug Users in Tehran, 2013

Tahmineh Kandelouei, Maryam Vaezjalali




Background: Hepatitis B virus (HBV) still continues to infect many people worldwide despite the availability of an effective vaccine for more than three decades. The high prevalence of HBV may exist in high risk groups, particularly among intravenous drug users (IDUs). This group is among groups with a higher risk of infection due to their hazardous behaviors such as sharing needles for drug injection. This cross sectional study included 229 intravenous drug users in Tehran, in 2013 to investigate the prevalence of HBc Ab positivity and its associated risk factors among IDUs.

Materials and Methods: Socio-demographic characteristics and associated risk factors were recorded during sample collection. Their serum samples were tested for the presence of total hepatitis B virus core antibody (HBc Ab) by Enzyme-linked Immunosorbent Assay (ELISA).

Results: HBc Ab was detected in 64 of 229 participants, giving an overall prevalence of 28%. History of imprisonment, injecting drugs and age has a significant correlation with HBc Ab positivity.

Conclusion: Expansion of new preventive strategies through the national health system could be beneficial for decreasing the risk of acquiring HBV among high risk groups such as IDUs.


Hepatitis B virus; drug user; antibody; infection control


Lugoboni F, Quaglio G, Civitelli P, Mezzelani P. Bloodborne viral hepatitis infections among drug users: the role of vaccination. International journal of environmental research and public health. 2009;6(1):400-13.

Schleicher S, Schieffer M, Jürgens S, Wehner H, Flehmig B. Evidence of multiple hepatitis virus infections in autopsied materials of intravenous drug addicts. Igiene e sanita pubblica. 2004;61(5):435-50.

Karimi A. P. 483 Seroprevalence of HBV, HCV and HIV among intravenous drug users in Iran. Journal of Clinical Virology. 2006;36:S210-S1.

Forouzanfar M, Mohammad K, Majdzadeh R, Malekzadeh R, ABOU AF, Mohammadnejad M, et al,. EFFECTIVENESS OF ADOLESCENTS'IMMUNIZATION AGAINST HEPATITIS B ON BURDEN OF THE DISEASE IN IRAN. Hakim. 2006;9(2):1-.

Tofigi H, Ghorbani M, Akhlaghi M, Yaghmaei A, Mostafazadeh B, Farzaneh E, et al,. Incidence of Hepatitis B and HIV Virus at Cadaver of IV Drug Abusers in Tehran. Acta Medica Iranica. 2011;49(1):59-63.

Zamani S, Ichikawa S, Nassirimanesh B, Vazirian M, Ichikawa K, Gouya MM, et al,. Prevalence and correlates of hepatitis C virus infection among injecting drug users in Tehran. International Journal of Drug Policy. 2007;18(5):359-63.

Mir-Nasseri S, Poustchi H, Nasseri-Moghadam S, Nouraie S, Tahaghoghi S, Afshar P, et al,. HCV in intravenous drug users. Govaresh. 2012;10(2):80-6.

Asli M, Kandelouei T, Rahimyan K, Davoodbeglou F, Vaezjalali M. Characterization of Occult Hepatitis B Infection Among Injecting Drug Users in Tehran, Iran. Hepat Mon . 2016;16:e34763.

Kandelouei T, Hosseini SM, Gachkar l, Keyvani h, Davoodbeglou f, m v. Reduction in prevalence of hepatitis b surface antigen among intravenous drug users in tehran drop-in-centers Arch Clin Infect Dis 2013;8(2):1-8.

Merat S, Rezvan H, Nouraie M, Jamali J, Assari S, Abolghasemi H, et al,. The prevalence of hepatitis B surface antigen and anti-hepatitis B core antibody in Iran: a population-based study. Archives of Iranian medicine. 2009;12(3):225-31.

Ramezani A, Banifazl M, Eslamifar A, Aghakhani A. Serological pattern of anti-HBc alone infers occult hepatitis B virus infection in high-risk individuals in Iran. The Journal of Infection in Developing Countries. 2010;4(10):658-61.

Dana D, Zary N, Peyman A, Behrooz A. Risk Prison and Hepatitis B Virus Infection among Inmates with History of Drug Injection in Isfahan, Iran. The Scientific World Journal. 2013;2013.

Imani R, Karimi A, Kasaeeian N. The relevance of related-risk behaviors and seroprevalence of HBV, HCV and HIV infection in intravenous drug users from Shahrekord, Iran, 2004. Shahrekord University of Medical Sciences Journal. 2006.

Nokhodian Z, Yazdani MR, Yaran M, Shoaei P, Mirian M, Ataei B, et al,. Prevalence and risk factors of HIV, syphilis, hepatitis B and C among female prisoners in Isfahan, Iran. Hepatitis monthly. 2012;12(7):442.

Nokhodian Z, Yaran M, Adibi P, Kassaian N, Meshkati M, Ataei B. Seroprevalence of hepatitis B markers among incarcerated intravenous drug users. Journal of research in medical sciences: the official journal of Isfahan University of Medical Sciences. 2014;19(Suppl 1):S13.

Kassaian N, Ataei B, Yaran M, Babak A, Shoaei P. Hepatitis B and C among women with illegal social behavior in Isfahan, Iran: Seroprevalence and associated factors. Hepatitis monthly. 2011;11(5):368.

Amin-Esmaeili M, Rahimi-Movaghar A, Razaghi EM, Baghestani AR, Jafari S. Factors correlated with hepatitis c and b virus infections among injecting drug users in Tehran, IR Iran. Hepatitis monthly. 2012;12(1):23.

Mir-Nasseri MM, MohammadKhani A, Tavakkoli H, Ansari E, Poustchi H. Incarceration is a major risk factor for blood-borne infection among intravenous drug users: Incarceration and blood borne infection among intravenous drug users. Hepatitis monthly. 2011;11(1):19.

Backmund M, Meyer K, Schuetz C, Reimer J. Factors associated with exposure to hepatitis B virus in injection drug users. Drug and alcohol dependence. 2006;84(2):154-9.

Månsson A-S, Moestrup T, Nordenfelt E, Widell A. Continued transmission of hepatitis B and C viruses, but no transmission of human immunodeficiency virus among intravenous drug users participating in a syringe/needle exchange program. Scandinavian Journal of Infectious Diseases. 2000;32(3):253-8.

Ruan Y, Qin G, Yin L, Chen K, Qian H-Z, Hao C, et al,. Incidence of HIV, hepatitis C and hepatitis B viruses among injection drug users in southwestern China: a 3-year follow-up study. Aids. 2007;21:S39-S46.

Miller ER, Hellard ME, Bowden S, Bharadwaj M, Aitken CK. Markers and risk factors for HCV, HBV and HIV in a network of injecting drug users in Melbourne, Australia. Journal of infection. 2009;58(5):375-82.

DOI: https://doi.org/10.22037/nbm.v5i2.12347