Effect of 8 Weeks of High Intensity Interval Training on Plasma Levels of Adiponectin and Leptin in Overweight Nurses
Background: High intensity interval training (HIIT) is a novel training method which has received most attention in recent years. The aim of this study was to examine the effect of 8 weeks of high intensity interval training (HIIT) on plasma levels of adiponectin and leptin in overweight nurses.
Materials and Methods: 27 nurses (mean age 25.81±60 years, height 158.01±67 cm and weight 69.41±25 kg) were voluntarily selected and randomly assigned to three groups (each group 9 subjects): 1. HIIT (type 1) including 8 seconds of sprint running and 12 seconds of active recovery 2. HIIT (type 2) including 40-m shuttle run with maximum speed 3. Control group. HIIT (type 1) was performed for eight weeks, three sessions per week, each session 6-9 min. With more than 90% HRmax. HIIT (type 2) was applied for eight weeks, three sessions per week with more than 90% HRmax. The control group did not participate in any training protocol.
Results: The data were analyzed by the dependent t test and ANOVA. The results showed that the HIIT (type 1) and (type 2) had significant effects on plasma leptin decrease and plasma adiponectin concentration increase in nurses. One-way analysis of variance (ANOVA) was used to analyze the intergroup data at p˂0.05.
Conclusion: The results showed a significant difference in the variables (leptin and adiponectin) among HIIT (type 1), HIIT (type 2) and control.
Krisan A, Collins DE, Crain AM, Connie C, Singh M, et al. Resistance training enhances components of the Insulin signaling cascade in normal and Insulin-resistant skeletal muscle. J. Applyphysiol. 2004;96(5):1691-700.
Hotta K, Funahashi T, Noni L, HeidiK B, Yukio A, Barbra C, et al. Plasma concentrations of a novel, adipose specific protein, adiponection, in type to diabetic pations. Arterioscler Thrombvasc Biol. 2004;20:1595-9.
Toussirot E. Relationship between growth hormone IGF-1-IGFBP-3 axis and serum leptin levels with bone mass and body composition in patients with rheumatoid arthritis. Umatology. 2005;l(44):120.
Olmedillas H, Guerra B, Guadalupe-Grau A, Santana A, Dorado C, Serrano-Sanchez JA, et al. Training, leptin receptors and SOCS3 in human muscle. Int J Sports Med. 2011;32(5):319-26.
Solis-Perez E, Gimenezsalas Z. The role of leptin in obese children. Respyn. 2001;2(4).
Zafeirridis A, Smilios I, Considine RV, Tokmakidis SP. Serum Leptin esponses after acute resistance exercise protocols. J Appl Physiol. 2003;94:591-7.
Awad AB, Bradford PG. Adipose Tissue and Inflammation. Newyork: CRC Press. 2010;20.
Diez JJ, Iglesias P. The role of the novel adipocyte-derived hormone adiponectin in human disease. Eur J Endocrinol. 2003;148:293-300.
Weyer C, Funahashi T, Tanaka S, et al. Hypoadiponectinemia in obesity and type 2 diabetes: close association with insulin resistance and hyperinsulinemia. J Clin Endocrinol Metab. 2001;86:1930-5.
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest. 2006;116:1784-92.
Gil-Campos M, Canete RR, and Gil A. Adiponectin, the missing link in insulin resistance and obesity. Clin Nutr. 2004;23:963-74.
Goldstein BJ, Scalia R. Adiponectin: a novel adipokine linking adipocytes and vascular function. J Clin Endocrinol Metab. 2004;89:2563-8.
Hotta K, Funahashi T, Arita Y, et al. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients. Arterioscler Thromb Vasc Biol. 2000;20:1595-9.
Yamauchi T, Kamon J, Minokoshi Y, et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med. 2002;8:1288-95.
Kawano T, Saito T, Yasu T, et al. Close association of hypoadiponectinemia with arteriosclerosis obliterans and ischemic heart disease. Metabolism. 2005;54:653-6.
Silha JV, Krsek M, Skrha JV, Sucharda P, Nyomba BL, Murphy LJ. Plasma resistin, adiponectin and leptin levels in lean and obese subjects: correlations with insulin resistance. Euro J Endocrinol. 2003;149:331-5.
Yokoyama H, Emoto M, Araki T, et al. Effect of aerobic exercise on plasma adiponectin levels and insulin resistance in type 2 diabetes. Diabetes Care. 2004;27:1756-8.
Monzillo LU, Hamdy O, Horton ES. Effect of lifestyle modification on adipokine levels in obese subjects with insulin resistance. Obesity Research. 2003;11:1048-54.
Spranger J, Kroke A, Möhlig M, et al. Adiponectin and protection against type 2 diabetes mellitus. Lancet. 2003;361:226-8.
Kumada M, Kihara S, Sumitsuji S, et al. Association of hypoadiponectinemia with coronary artery disease in men. Arterioscler Thromb Vasc Biol. 2003;23:85-9.
Krimer AK, Gan SK, Poynten AM, Furler SM, Chisholm DJ, Campbell LV. Exercise increases adiponectin levels and insulin sensitivity in humans. Diabetes Care. 2004;27:629-31.
Richards JC, Johnson TK, KuzmaJN, Lonac MC, Schweder M M, VoylesWF. Short-termsprint interval training increases insulin sensitivity in healthy adults but does not affect the thermogenic response to â-adrenergic stimulation. J Physiol. 2010;588:2961-72.
Kraemer RR, Castracane VD. Exercise and humoral mediators of peripheral energy balance:ghrelin and adiponectin. Experimental Biology and Medicine. 2007;232:184-94.
Zeng Q, Isobe K, Fu L, et al. Effects of exercise on adiponectin and adiponectin receptor levels in rats. Life Sciences. 2007;80: 454-9.
TrappEG, Chisholm DJ, Freund J, Boutcher SH. The effects of high-intensity intermittent exercise training on fat loss and fasting insulin levels of young women. Inter J Obes. 2008;32:684-91.
Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: A simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402-10.
Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and â-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 2004;30:412-9.
Garekania ET, Mohebbib H, Kraemer R R., Fathia R. Exercise training intensity/volume affects plasma and tissue adiponectin concentrations in the male rat. Peptides. 2011;32:1008-12.
Bahceci M, Gokalp D, Bahceci S, Tuzcu A, Atmaca S, Arikan S. The correlation between adiposity and adiponectin, tumor necrosis factor alpha, interleukin-6 and high sensitivity reactive protein levels. Is adipocyte size associated with inflammation in adults?. J Endocrinol Invest. 2007; 30: 210-4.
Buchan S D, Ollis S T, Young JD, et al. The effects of time and intensity of exercise on novel and established markers of cvd in adolescent youth. Am J Hum Biol. 2004;23:517-26.
Metcalf BS, Jeffery AN, Hosking J, Voss LD, Sattar N, Wilkin TJ.Objectively measured physical activity and its association with adiponectin and other novel metabolic markers: a longitudinal study in children (EarlyBird 38). Diabetes care. 2009;32:468-73.
Platat C, Wagner A, Klumpp T, Schweitzer B, Simon C. Relationships of physical activity with metabolic syndrome features and low-grade inflammation in adolescents. Diabetologia. 2006;49:2078-85.
Emken BA, Richey J, Belcher B, Hsu YW, Spruijt-Metz D. Objectively measured physical activity is negatively associated with plasma adiponectin levels in minority female youth". Int J Pediatr Endocrinol. 2010;347:636-8.
Boudou P, Sobngwi E, Mauvais-Jarvis F, Vexiau P, Gautier JF. Absence of xercise induced in variations adiponectin levels despite decreased abdominal adiposity and improved insulin sensitivity in type 2 diabetic men. Eur J Endocrinol. 2003;149:421-4.
Burgomaster KA, HeigenhauserGJ, Gibala MJ. Effect of short-term sprint interval training on human skeletal muscle carbohydrate metabolism during exercise and time-trial performance. J Appl Physiol. 2006;100:2041-7.
Burgomaster KA, Cermak NM, Phillips SM, Benton CR, Bonen A, Gibala MJ. Divergent response of metabolite transport proteins in human skeletal muscle after sprint interval training and detraining. J Physiol RegulIntegr Comp Physiol. 2003;292:1970-6.
Leary VB, Marchetti CM, Krishnan RK, Stetzer BP, Gonzalez F, Kirwan JP. Exercise induced reversal of insulin resistance in obese elderly is associated with reduced visceral fat. J Appl Physiol. 2006;100:1584-9.
Koh EH, Park JY, Park HS, et al. Essential role of mitochondrial function in adiponectin synthesis in adipocytes. Diabetes. 2007;56:2973-81.
Svacinivahm-Olsovsky J, Zakova V, Jancik J, Placheta Z, Siegelova J. The effect of Walking exercise on aerobic capacity and serom lipids in type2 diabetes.VenitrLek. 2003;49:205-9.