Examination of the Steps and Attachment Circumstances of the Poly Lactic-co-glycolic Acid (PLGA) Nano-particle to Increase the Effect of Nanomedicine on Vancomycin-Resistant Enterococcus Faecalis
Materials and Methods: In this method, first, attachment made through chemical processes such as emulsion between vancomycin antibiotic and a PLGA nanoparticle, and resultant antibiotic tested on vancomycin resistant E. faecalis.
Results: The results of this study indicate that the method of nanomedicine attachment to antibiotics was an effective method and it was determined by X-ray Diffraction that the attachment was precisely performed. In the antibiogram method, the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of the nanomedicine increased in respect to vancomycin antibiotic.Conclusion: The results showed that produced Nano-antibiotics had a better effect than resistant antibiotics.
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