Rare case of bilateral vassal agenesis and AZFc microdeletion: A case report
Men's Health Journal,
Vol. 2 No. 1 (2018),
13 July 2018
,
Page e3
https://doi.org/10.22037/mhj.v2i1.22121
Abstract
Introduction: Bilateral vassal agenesis (CBAVD) is a rare cause of male infertility. Also one of the nonobstructive cause of azoospermia and infertility in men is microdeletion in long arm of Y chromosome. In this case report we have reported a rare case of CBAVD, LT renal agenesis and AZFc microdeletion.
Patient Information:
28 years old man, who was farmer with history of 6 years of infertility presented to our andrology clinic in Royan institute. In physical examination there was not any palpable vas deferens bilaterally, also The semen analysis was azoospermia. In sonographic evaluation, LT kidney wasn’t seen in its anatomic location. The patient candidate for diagnostic PESA and bilateral PESA were negative. After that, the patient candidate for bilateral TESE and fascinatingly TESE was negative too. After genetic evaluation microdeletion was detected in AZFc subregion of Y chromosome.
Conclusion:
In men with obstructive azoospermia mostly testicular spermatogenesis is normal but this is not the rule because seldom spermatogenic dysfunction maybe present like our patient. We emphasize about the importance of consideration of obstructive and nonobstructive azoospermia together in a patient for urologists.
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References
Jianmin Yu, Zhanghui Chen, Ya Ni, and Zhongxiang Li. CFTR mutations in men with congenital bilateral absence of the vas deferens (CBAVD): a systemic review and meta-analysis. Human Reproduction, Vol.27, No.1 pp. 25–35, 2012.
Kamal A, Fahmy I, Mansour R, et al. Does the outcome of ICSI in cases of obstructive azoospermia depend on the origin of the retrieved spermatozoa or the cause of obstruction? A comparative analysis. Fertil Steril 2010; 94:2135–40.
Wein AJ, kavoussi LR, Partin AW,Peters CA .Campbell Walsh urology.11 th edition.Elsevier.2015 ;571.
Niederberger CS. Clinical evaluation of the male. In: Niederberger CS,editor. An introduction to male reproductive medicine. New York: Cambridge University Press; 2011. p. 29–57.
Schlegel PN, Shin D, Goldstein M. Urogenital anomalies in men with congenital absence of the vas deferens. J Urol 1996; 155:1644–8.
Navarro-Costa P. Sex, rebellion and decadence: the scandalous evolutionary history of the human Y chromosome. Biochim Biophys Acta 2012; 1822:1851–63.
Tiepolo L, Zuffardi O. Localization of factors controlling spermatogenesis in the nonfluorescent portion of the human Y chromosome long arm.Hum Genet 1976;34:119–24.
Oates RD, Lamb DJ. Genetic aspects of infertility. In: Lipshultz LI, Howards SS, Niederberger CS, editors. Infertility in the male. 4th ed. New York:Cambridge University Press; 2009. p. 251–76.
Saxena R, de Vries JW, Repping S, et al. Four DAZ genes in two clusters found in the AZFc region of the human Y chromosome. Genomics 2000; 67:256–67.
Goldstein, M et al.men with congenital absence of the vas deferens often have seminal vesicles.J UROL ,140,85-86.
Maxwell V.Meng et al.Impaired spermatogenesis in men with congenital absence of the vas deferens.Human reproduction 2001,vol 16,529-533.
Okada,h et al.Assisted reproduction technology for patients with congenital bilateral absence of vas deferens.J UROL,161,1157-1162.
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