A comparative study of genotoxicity and oxidative stress before and after using lemon balm and cinnamon in subjects exposed to Nickel Welding Fumes

Gholamhassan Vaezi, Jose G Dorea, Ali Akbar Malekirad, Hamed Zarei



     By producing reactive oxygen and nitrogen species, metal-induced toxicity and carcinogenicity alter DNA bases, increase  lipid peroxidation, and change calcium and sulfhydryl homeostasis. The purpose of the study was to investigate putative effects of Lemon balm and Cinnamomum zeylanicum on the blood markers of welding workers. We measured nickel and chromium levels, biochemical parameters, blood oxidative stress markers, total antioxidant capacity (TAC), Myeloperoxidase (MPO), lipid peroxidation (LPO), and DNA damage. The study was conducted on 55 male workers who worked in an industrial subjects exposed to Nickel Welding Fumes. The participants were administered Lemon balm and Cinnamon extract infusion 1.5 (0.12 extract) and 0.25(0.013 extract) g/100 mL, respectively, they have drunken twice a day for 30 days at 7:00 AM and 2:00 PM every day. In order to analyze the achieved data, paired t-test and Pearson correlation coefficient have been used. After using the extract infusion, a significant increase revealed in TAC (p= 0.007). Also, administration of infusion decreased DNA damage but it was not statistically significant. After administration of infusion, a decrease in LPO and MPO were observed (p= 0.014, p=0.000 respectively). Also there is positive correlation between ALP and Ni with 8-oH-dG and also, between Ni and TAC. The results indicate that using infusion causes to raise in a TAC and reduce in DNA damage.


Nickel Welding Fumes; Oxidative stress; Genotoxicity; Lemon balm; Cinnamomum zeylanicum

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DOI: https://doi.org/10.22037/jps.v5i4.7799


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"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

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EISSN: 2008-4978

PISSN: 2008-496X