A concentration of serum selenium in multiple sclerosis patients compare to healthy subject in Tehran

Fariba Fathi--- Department of Chemistry, Sharif University of Technology, Tehran,
Masoud Mehrpour--- Department of Neurology, Tehran University of Medical Sciences, Tehran,
Mohammad Esmaeil Akbari--- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran,
Kaveh Sohrabzadeh--- Department of electrical engineer, Payam nonprofit higher education institution, Golpayegan,
Soraya Fathi--- Department of Mathematics, Teacher Training University, Tehran,
Mohammad-Taghi Joghataie--- Cellular and molecular Research Center, Tehran University of Medical Sciences, Tehran,
Mohammad Rostami Nejad--- Gastroenterology and Liver diseases Research Center, Shahid Beheshti University of Medical Sciences, Tehran

Abstract


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     Multiple sclerosis (MS) is an inflammatory demyelinating disease which the exact etiology is still are far to be clear. Reasons for this autoimmune disease are unknown origin. The aim of present study was to evaluate serum levels of selenium in patient with MS compare to healthy subjects. A total of 46 subjects were enrolled in the study, Sera of 23 MS cases and 23 healthy normal cohorts as control group were obtained. Atomic absorption spectrophotometer was employed for estimating serum selenium level. Serum
selenium levels were significantly lower in MS than in control cohorts (60.87±13 compared with 85.74±12, P-value < 0.0001). Serum selenium levels may thus be a marker of MS; the decreasing levels of serum selenium may be host defense strategies of body.


Keywords


Multiple sclerosis; Selenium; Atomic absorption spectrophotometer; Serum.

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DOI: http://dx.doi.org/10.22037/jps.v4i4.4807

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"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

"Journal of Paramdedical Sciences" is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

EISSN: 2008-4978

PISSN: 2008-496X