Comparative Study of Serum levels of Granzyme H & Estrogen In Patients Suffering From Breast Cancer

Behnoosh Tahbaz lahafi--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran,
Houshang Amirrassouli--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran,
Mohammad Esmaeil Akbari--- Cancer Research Center,Shohada Hospital, Shahid Behesht University of Medical Sciences,Tajrish,Tehran,
Saeed Namaki--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran,
Faranak Kazerouni--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran,
Ali Rahimipour--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran,
Jahangir Mohammadzadeh--- Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran

Abstract


102

GranymeH is a functional cytotoxic serine protease of NK cell granules,which expands the cell death-inducing repertoire of innate immune system.The purpose of this study was to determine GranymeH(GZMH)level in breast cancer(BC) and healty women.This study was performed on 30 patients with BC and 30 healty woman.GZMH and Estrogen levels were measured in cancer patients  and healty women subsequently using ELISA and Radioimmunoassay(RIA) methods. Mean GZMH value was lower in BC than healty women(p<0.0001) and  mean Estrogen level was  higher  in BC patients  in comparison to healty women (p<0.003).Our finding indicates probability of existance of suppressor or a problem in production of GZMH in cancer patients

Keywords


Breast Cancer; Estrogen; Granzyme H

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DOI: http://dx.doi.org/10.22037/jps.v4i0.4027

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"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

"Journal of Paramdedical Sciences" is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

EISSN: 2008-4978

PISSN: 2008-496X