Herpes simplex encephalitis: successful treatment with Acyclovir

Parviz Fallah, Ali ehsan Heidari, Enayatollah Kalantar, Mohammad Hosein Dehghan, Fatemeh Rahimi, Morteza Nazari, Sasan Fardoust




One of the most common causes of encephalitis is due viral infection like herpes simplex. Traditionally, brain biopsy was required for the diagnosis of HSV encephalitis; however, here we report CSF PCR detection for herpes simplex encephalitis which was successfully treated with Acyclovir.

Case presentation:

 A 52 years old female patient brought to emergency department with fever (400C), constipation, abdominal pain, fatigue, disorientation, agitation, from two days ago. DNA extraction and Real Time PCR was performed on CSF sample for HSV-1/2 and HSV-1 was positive. Also the brain MRI report showed left and basal temporal oppression, left and basal frontal pus. The patient is discharged after 20 days of hospitalization and treatment with acyclovir and normal physiological indexes and had a good clinical and neurologic outcome with resolution of all the symptoms.


We would like to emphasize, despite the normal biochemical CSF, imaging results and PCR are convinced evidence of HSV encephalitis.



HSV, encephalitis, Acyclovir

Full Text:




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DOI: https://doi.org/10.22037/jps.v10i1.19886


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"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

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EISSN: 2008-4978

PISSN: 2008-496X