The Detection of HDL receptor on platelet surface in patients with Coronary artery disease (CAD)

Parisa Nehzati, Mohsen Hamidpour, Davod Bashash, Mahin Nikoogoftar, Mohammad Reza Hedari, Ali Akbar Khadem Mabodi

Abstract


446

The human scavenger receptor B1 (hSR-B1/CLA) is a HDL receptor with various anti-atherogenic functions which is expressed on the platelet surface. The anti thrombotic function of HDL includes the modulation of platelet reactivity, coagulation, and endothelial function. The goal of this study is to detect the level of HDL receptor on platelets of CAD patients with atherosclerotic disease. Expressions of the hSRB1 receptor on platelets of 31 CAD patients with atherosclerotic plaque and 20 healthy controls was detected using flow cytometry. Moreover, the lipid panel tests were assayed by Chemistry auto analyzer and compared with healthy controls. Our findings show that abundance of hSR-B1/CLA-1 was significantly reduced on the surface of platelets from CAD patients with atherosclerotic disease compared with healthy control (6/8 % vs. 13/6 %), (P <0,001). The HDL receptor (hSR-B1/CLA-1) expression on platelets inversely correlates with the risk of coronary heart disease.  Our findings suggest that determining the level of hSR-B1/CLA-1 on the platelets may be a useful laboratory marker for CAD investigation.


Keywords


CAD, platelet, HDL receptor

Full Text:

PDF

132



DOI: https://doi.org/10.22037/jps.v8i1.15310

Refbacks

  • There are currently no refbacks.


"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

"Journal of Paramdedical Sciences" is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

EISSN: 2008-4978

PISSN: 2008-496X