Early effect of radiation on the liver functional tests of patients with thoracic and abdominal tumors during radiotherapy

Rojin Zahedi--- Department of Radiology Technology, Faculty of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.,
Mohsen Bakhshandeh--- Department of Radiology Technology, Allied Medical Faculty, shahid beheshti University of Medical Sciences,
Hojatolah Sabouri--- Department of Radiation Oncology, tohid hospital, Kurdistan University of Medical Sciences, sanandaj, Iran,
Mehran Yar Ahmadi--- Department of Radiation Oncology, tohid hospital, Kurdistan University of Medical Sciences, sanandaj, Iran,
Amir Nami--- Department of Radiation Oncology, tohid hospital, Kurdistan University of Medical Sciences, sanandaj, Iran,
Daem Roshani--- medicine faculty, Kurdistan University of Medical Sciences, sanandaj, Iran

Abstract


102

The liver is an organ at risk (OAR) in radiotherapy of thoracic and abdominal tumors such as gastric, distal esophagus, lower lung and breast, bile duct, pancreas and whole abdomen. In this study the alteration in liver functional tests (LFT) of these patients during radiotherapy was investigated. To that end, the level of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), direct and total bilirubin were checked out at different times (before radiotherapy and every 2 weeks after the start of radiotherapy and followed up to 2 months after the end of treatment). The results showed that LFT level increased during radiotherapy while they gradually decreased after treatment. Our results showed that the LFT serum is a very sensitive and useful biomarker for evaluation of the radiotherapy effects.

 


Keywords


liver functional test, thoracic and abdominal tumors, radiotherapy

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DOI: http://dx.doi.org/10.22037/jps.v7i3.11864

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"Journal of Paramdedical Sciences", is a publication of "School of Paramedical Sciences, Shahid Beheshti University of Medical Sciences" and "Iranian Society of Medical Proteomics".

"Journal of Paramdedical Sciences" is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

EISSN: 2008-4978

PISSN: 2008-496X