Outcomes of Lensectomy in Hereditary Lens Subluxation

Mohammad-Hossein Dehghan, Reza Soleimanizad, Hamid Ahmadieh, Mohsen Azarmina, Masoud Soheilian, Siamak Moradian, Masoumeh Sanagoo



Purpose: To evaluate the results of pars plana lensectomy in patients with hereditary lens subluxation.

Method: Hospital records of patients with hereditary lens subluxation who had undergone pars plana lensectomy at Labbafinejad Medical Center, Tehran-Iran from 1996 to 2003 were reviewed. Patients with more than 6 months of follow up were included. Underlying disorders, best corrected visual acuity (BCVA) before and after surgery, intraocular pressure (IOP), postoperative refraction and complications were evaluated.

Results: Overall, records of 87 eyes of 49 patients including 27 male and 22 female subjects were reviewed. Mean follow up duration was 20±18 months. Underlying disorders leading to lens subluxation included Marfan syndrome (79.5%), Weill-Marchesani syndrome (8.2%), simple ectopia lentis (8.2%), and homocystinuria (4.1%). The most common indication for surgery was non-correctable refractive error (92.1%). Mean BCVA was 1.13 LogMAR (20/250) preoperatively, which improved to 0.26 LogMAR (20/30-20/40) postoperatively (P<0.001). BCVA ≥20/40 was achieved in 82.8% of cases after surgery. Angle-supported anterior chamber intraocular lens (ACIOL) was implanted in 85.1% of the eyes. Prophylactic band was applied in 63 eyes (72.4%). Retinal detachment developed in four eyes (4.6%) and was successfully treated.

Conclusions: Lensectomy/anterior vitrectomy with implantation of an angle-supported ACIOL in patients with hereditary lens subluxation improves vision significantly without considerable complications.

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