Randomized controlled trials as sources of information in evidence based medicine

Seed Amir Mohsen Rezaiee

Abstract


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Physicians are constantly challenged by their patients, the media, and the rapid pace of technological advance 10 keep abreast of new diagnostic and therapeutic developments. Evidence-based medicine (EBM) is the practice of making updated medical decisions through the judicious identification, evaluation, and application of the most relevant published information. RCTs are one of the best primary sources used in EBM  Thus, evaluation of the strength and validity of the RCTs that supports the discussion on making medical decisions seems to be necessary. Jn this paper, main types of biases occurred during the course of an RCT as well as Assessment of RCTs as sources of information in evidence-based medicine are discussed.

Key Words:  randomized controlled trial, evidence based medicine, assessment

Keywords


randomized controlled trial, evidence based medicine, assessment

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References


Rosen S. Evidence-based medicine is gaining ground with clinicians.BBI newsletter, 2002.

Sackett David, Etraus ES, et al. How to practice and teach EBM. Evidence based medicine.2th ed: Churchill Livingstone, 2001.

- Scketi D, Straus ES. Richardson WS. How to find current best evidence. Evidence based medicine. 2Th ed: Churchill-Livingston, 200I.

- Silvermam WA, chalmers, et.al. An appreciation, controlled clinical trials. 1992; 13:

-5.

- Jadad AR, Rennie D. The randomized controlled trials gets a Middle-aged checkup. JAMA 1995;279:319-20.

- Jadad RA. Randomized controlled trials: the basic.BMJ Books,1998.

- Jadad RA. Randomized controlled trials, A users guide. BMJ Books,1998.

- Jadad RA.Bias in RCTS: Beyond the sequence generation. BMJ Books,1998.

- colditz GA. Meller JN, Mosteller F.How study design affect outcomes in comparisons of therapy .Therapy Stat Med 1989;5:441-54.

- Schulzk F, Grimes DA, et al. Blinding and exclusions after allocation in RCTs.BMJ 1996;312:742-4.

-Jadad AR, Moore RA, et al. Assessing the quality of reports on RCTs, is blinding necessary. Controlled Clin Trails 1996;17:1- 12.

-Moher D, Jadad AR, et al.Assessing the quality of RCTs :An ahhotated biblography of scale cheklists. Controlled Clin Trails 1995;16:62-73.

-0hlsson A, Lacy JB, et al. Quality assessment of RCTs:Evaluation by the chalmers vesus Jadad method. Annual Cochrane Calloquium 1995:V9-Vl0.

- Bender JS, Halpern SH, et al. Quality and retrieval of obstetrical anesthesia RCTs. Can J Anesth 1997:14-18.




DOI: https://doi.org/10.22037/jme.v2i2.884

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