Evaluation of Effectiveness of Photodynamic Therapy With Low-level Diode Laser in Nonsurgical Treatment of Peri-implantitis
Journal of Lasers in Medical Sciences,
Vol. 8 No. 3 (2017),
30 Tir 2017
,
Page 136-142
Abstract
Introduction: Side effects related to antibiotic therapy for peri-implantitis are rare in laser therapy (LT); therefore, the aim of this study was to evaluate the effectiveness of LT and photodynamic therapy (PDT) on patients with primary peri-implantitis.Methods: In this randomized clinical trial, 40 implants presenting primary peri-implantitis in 20 patients with a mean age of 52.6 years old were included using the simple sampling technique. Periodontal treatment comprising scaling and root planing (SRP) was accomplished for the whole mouth while mechanical debridement with titanium curettes and air polishing with sodium bicarbonate powder was accomplished around the implants. The implants were randomly divided into two groups and treated with LT (control) and PDT (test). The clinical indices were measured at baseline, 6 weeks and 3 months after treatment. Real-time polymerase chain reaction (PCR) was used for analysis of microbial samples at baseline and 3-month follow-up. Data were analyzed with SPSS 20, using repeated-measures analysis of variance (ANOVA) and Friedman’s and Mann-Whitney tests (α = 0.05).
Results: Both groups showed statistically significant improvements in terms of bleeding on probing (P < 0.001), probing pocket depth (PPD) (P = 0.006) and modified plaque index (P < 0.001), with no significant differences between the 2 groups (P > 0.05). The number of Aggregatibacter actinomycetemcomitans (P = 0.022), Tannerella forsythia (P = 0.038) and Porphyromonas gingivalis (P = 0.05) in the test group and Porphyromonas gingivalis (P = 0.015) in the control group significantly decreased.
Conclusion: The results suggested that LT and PDT have significant short-term benefits in the treatment of primary peri-implantitis.
- Diode laser
- peri-implantitis
- photosensitizer
- photodynamic therapy.
How to Cite
References
Roncati M, Lucchese A, Carinci F. Non-surgical treatment of peri-implantitis with the adjunctive use of an 810-nm diode laser. J Indian Soc Periodontol. 2013;17(6):812-815. doi: 10.4103/0972-124X.124531.
Schar D, Ramseier CA, Eick S, Arweiler NB, Sculean A, Salvi GE. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: six-month outcomes of a prospective randomized clinical trial. Clin Oral Implants Res. 2013;24(1):104-110. doi: 10.1111/j.1600-0501.2012.02494.x.
Novaes AB Jr, Schwartz-Filho HO, de Oliveira RR, Feres M, Sato S, Figueiredo LC. Antimicrobial photodynamic therapy in the non-surgical treatment of aggressive periodontitis: microbiological profile. Lasers Med Sci. 2012;27(2):389-395. doi: 10.1007/s10103-011-0901-6.
Feres M, Bernal M, Matarazzo F, Faveri M, Duarte PM, Figueiredo LC. Subgingival bacterial recolonization after scaling and root planing in smokers with chronic periodontitis. Aust Dent J. 2015;60(2):225-232. doi: 10.1111/adj.12225.
Zhu C, Yang J, Sun J, Shi J, Gou J, Li A. Induction of immune response and prevention of alveolar bone loss with recombinant Porphyromonas gingivalis peptidylarginine deiminase. Arch Oral Biol. 2013;58(12):1777-1783. doi: 10.1016/j.archoralbio.2013.09.006.
Feres M, Soares GMS, Mendes JAV, et al. Metronidazole alone or with amoxicillin as adjuncts to non‐surgical treatment of chronic periodontitis: a 1‐year double‐blinded, placebo‐controlled, randomized clinical trial. J Clin Periodontol. 2012;39(12):1149-1158.
Krishna MK, Ravindran SK, Vivekanandan G, Navasivayam A, Thiagarajan R, Mohan R. Effects of a single episode of subgingival irrigation with tetracycline HCl or chlorhexidine: a clinical and microbiological study. J Indian Soc Periodontol. 2011;15(3):245.
Sperandio FF, Huang YY, Hamblin MR. Antimicrobial photodynamic therapy to kill gram-negative bacteria. Recent Pat Antiinfect Drug Discov. 2013;8(2):108-120.
Ethirajan M, Chen Y, Joshi P, Pandey RK. The role of porphyrin chemistry in tumor imaging and photodynamic therapy. Chem Soc Rev. 2011;40(1):340-362. doi: 10.1039/ b915149b.
Cassidy CM, Donnelly RF, Elborn JS, Magee ND, Tunney MM. Photodynamic Antimicrobial Chemotherapy (PACT) in combination with antibiotics for treatment of Burkholderia cepacia complex infection. J Photochem Photobiol B. 2012;106:95-100. doi: 10.1016/j. jphotobiol.2011.10.010.
Mang TS, Tayal DP, Baier R. Photodynamic therapy as an alternative treatment for disinfection of bacteria in oral biofilms. Lasers Surg Med. 2012;44(7):588-596. doi: 10.1002/lsm.22050.
Takasaki AA, Aoki A, Mizutani K, Schwarz F, Sculean A, Wang CY, et al. Application of antimicrobial photodynamic therapy in periodontal and peri-implant diseases. Periodontol 2000. 2009;51:109-40. doi: 10.1111/j.1600- 0757.2009.00302.x.
Dortbudak O, Haas R, Bernhart T, Mailath-Pokorny G. Lethal photosensitization for decontamination of implant surfaces in the treatment of peri-implantitis. Clin Oral Implants Res. 2001;12(2):104-108.
Haas R, Baron M, Dortbudak O, Watzek G. Lethal photosensitization, autogenous bone, and e-PTFE membrane for the treatment of peri-implantitis: preliminary results. Int J Oral Maxillofac Implants. 2000;15(3):374-382.
Garcez AS, Ribeiro MS, Tegos GP, Nunez SC, Jorge AO, Hamblin MR. Antimicrobial photodynamic therapy combined with conventional endodontic treatment to eliminate root canal biofilm infection. Lasers Surg Med. 2007;39(1):59-66.
Bagchi B, Basu S. Role of dye molecules remaining outside the cell during photodynamic inactivation of Escherichia coli in the presence of acriflavine. Photochem Photobiol. 1979;29(2):403-405.
Theodoro LH, Silva SP, Pires JR, et al. Clinical and microbiological effects of photodynamic therapy associated with nonsurgical periodontal treatment. A 6-month follow-up. Lasers Med Sci. 2012;27(4):687-693. doi: 10.1007/s10103-011-0942-x.
Ehrenberg B, Gross E, Nitzan Y, Malik Z. Electric depolarization of photosensitized cells: lipid vs. protein alterations. Biochim Biophys Acta. 1993;1151(2):257-264.
Pereira Gonzales F, Maisch T. Photodynamic inactivation for controlling Candida albicans infections. Fungal Biol. 2012;116(1):1-10.
Meisel P, Kocher T. Photodynamic therapy for periodontal diseases: state of the art. J Photochem Photobiol B. 2005;13;79(2):159-170.
Kreisler M, Al Haj H, d’Hoedt B. Clinical efficacy of semiconductor laser application as an adjunct to conventional scaling and root planing. Lasers Surg Med. 2005;37:350-355.
Romanos GE, Henze M, Banihashemi S, Parsanejad HR, Winckler J, Nentwig GH. Removal of epithelium in periodontal pockets following diode (980 nm) laser application in the animal model: an in vitro study. Photomed Laser Surg. 2004;22(3):177–183.
Cobb CM. Lasers in periodontics: a review of the literature. J Periodontol. 2006;77(4):545-564.
Saxer U, Mühlemann H. Motivation and education (German). SSO Schweiz Monatsschr Zahnheilkd. 1975;85(9):905-919.
Mombelli A, Oosten M, Schürch E, Lang N. The microbiota associated with successful or failing osseointegrated titanium implants. Oral Microbiol Immunol. 1987;2(4):145- 151.
Salvi GE, Persson GR, Heitz-Mayfield LJ, Frei M, Lang NP. Adjunctive local antibiotic therapy in the treatment of peri-implantitis II: clinical and radiographic outcomes. Clin Oral Implants Res. 2007;18(3):281-285.
Birang R, Yaghini J, Adibrad M, Kiany S, Mohammadi Z, Birang E. The effects of diode laser and chlorhexidine gel in the treatment of chronic periodontitis. J Lasers Med Sci. 2011;2(4):131-8
Gojkov-Vukelic M, Hadzic S, Dedic A, Konjhodzic R, Beslagic E. Application of a diode laser in the reduction
of targeted periodontal pathogens. Acta Inform Med. 2013;21(4):237-240. doi: 10.5455/aim.2013.21.237-240.
Moritz A, Schoop U, Goharkhay K, et al. Treatment of periodontal pockets with a diode laser. Lasers Surg Med. 1998;22:302–311.
Angelov N, Pesevska S, Nakova M, et al. Periodontal treatment with a low-level diode laser: clinical findings. Gen Dent. 2009;57(5):510-513.
Marcacci A. Sur l’action des alcaloides dans le regne vegetal et animal. Arch Ital Biol. 1888;9:2-4.
Von Tappeiner H. Uber die Wirkung fluoreszierender Stoffe auf Infusorien nach Versuchen von O. Raab. Muench Med Wochenschr. 1900;47:5.
Blum HF. Photodynamic action and diseases caused by light. J Nerv Ment Dis. 1943;98(3):332.
Spikes JD, Livingston R. The molecular biology of photodynamic action: sensitized photo-autooxidations in biological systems. In: Augenstein L, Mason R, Zelle M, eds. Advances in Radiation Biology. New York: Academic Press; 1967:29-121.
Andersen R, Loebel N, Hammond D, Wilson M. Treatment of periodontal disease by photodisinfection compared to scaling and root planing. J Clin Dent. 2007;18(2):34-38.
Braun A, Dehn C, Krause F, Jepsen S. Short-term clinical effects of adjunctive antimicrobial photodynamic therapy in periodontal treatment: a randomized clinical trial. J Clin Periodontol. 2008;35(10):877-884.
Azarpazhooh A, Shah PS, Tenenbaum HC, Goldberg MB. The effect of photodynamic therapy for periodontitis: a systematic review and meta-analysis. J Periodontol. 2010;81(1):4-14. doi: 10.1902/jop.2009.090285.
Shibli JA, Martins MC, Theodoro LH, Lotufo RF, Garcia VG, Marcantonio EJ. Lethal photosensitization in microbiological treatment of ligature-induced peri-implantitis: a preliminary study in dogs. J Oral Sci. 2003;45(1):17-23. doi: 10.1007/s00784-012-0845-7.
Gursoy H, Ozcakir-Tomruk C, Tanalp J, Yilmaz S. Photodynamic therapy in dentistry: a literature review. Clin Oral Investig. 2013;17(4):1113-1125.
Bassetti M, Schar D, Wicki B, et al. Anti-infective therapy of peri-implantitis with adjunctive local drug delivery or photodynamic therapy: 12-month outcomes of a randomized controlled clinical trial. Clin Oral Implants Res. 2014;25(3):279-287. doi: 10.1111/clr.12155.
Traini T, Degidi M, Iezzi G, Artese L, Piattelli A. Comparative evaluation of the peri-implant bone tissue mineral density around unloaded titanium dental implants. J dent. 2007;35(1):84-92.
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