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The Effect of Polarized Polychromatic Noncoherent Light (Bioptron) Therapy on Patients with Carpal Tunnel Syndrome

Seyed Ahmad Raeissadat, Seyed Mansoor Rayegani, Sajad Rezaei, Leyla Sedighipour, Mohammad Hasan Bahrami, Dariush Eliaspour, Afshin Karimzadeh




Introduction: To study the effects of Polarized Polychromatic Noncoherent Light (Bioptron) therapy on patients with carpal tunnel syndrome (CTS).

Methods: This study was designed as a randomized clinical trial. Forty four patients with mild or moderate CTS (confirmed by clinical and electrodiagnostic studies) were assigned randomly into two groups (intervention and control goups). At the beginning of the study, both groups received wrist splinting for 8 weeks. Bioptron light was applied for the intervention group (eight sessions, for 3/weeks). Bioptron was applied perpendicularly to the wrist from a 10 centimeters distance. Pain severity and electrodiagnostic measurements were compared from before to 8 weeks after initiating each treatment.

Results: Eight weeks after starting the treatments, the mean of pain severity based on Visual Analogue Scale (VAS) scores decreased significantly in both groups. Median Sensory Nerve Action Potential (SNAP) latency decreased significantly in both groups. However, other electrophysiological findings (median Compound Motor Action Potential (CMAP) latency and amplitude, also SNAP amplitude) did not change after the therapy in both groups. There was no meaningful difference between two groups regarding the changes in the pain severity.

Conclusion: Bioptron with the above mentioned parameters led to therapeutic effects equal to splinting alone in patients with carpal tunnel syndrome. However, applying Bioptron with different therapeutic protocols and light parameters other than used in this study, perhaps longer duration of therapy and long term assessment may reveal different results favoring Bioptron therapy.


syndrome, carpal tunnel; noncoherent light; electrodiagnostic study


Salaffi F, De Angelis R, Grassi W ; MArche Pain Prevalence; INvestigation Group (MAPPING) study. Prevalence of Musculoskeletal conditions in an Italian population sample. Clin Exp Rheumatol 2005;23:819-28.

Robert A, Werner R, Andray M. Electrodiagnostic evaluation of carpal tunnel syndrome. Muscle Nerve 2011;44:597–607.

Bonfiglioli R, Mattioli S, Fiorentini C, Graziosi F, Curti S, Violante FS. Relationship between repetitive work and the prevalence of carpal tunnel syndrome in part-time and full-time female supermarket cashiers: a quasi-experimental study. Int Arch Occup Environ Health 2007;80:248-53.

Dumitru D, Amato A.A, Zwart M.J:Electrodiagnostic Medicine. 2nd ed. Philadelphia:Hanley & Belfus, Inc 2002;p1058-70.

Naeser MA. Photobiomodulation of pain in Carpal tunnel syndrome: review of seven studies. Photomed Laser Surg 2006;24:101-10.

Nobuta S, Sato K, Nakagawa T, Hatori M, Itoi E. Effects of wrist splinting for Carpal Tunnel syndrome and motor nerve conduction measurements. Ups J Med Sci 2008;113:181-92.

Reddy M, Gill SS, Kalkar SR, Wu W, Anderson PJ, Rochon PA.Treatment of pressure ulcers: a systematic review.JAMA 2008;300:2647-62.

Jasmina Begic-Rahic, Sanja Vranic. The Application of Bioptron Light Therapy in Dermatology and Wound Healing. European Dermatolo 2010;5:57–60.

Kubasova T, Horváth M, Kocsis K, Fenyö M. Effect of visible light on some cellular and immune parameters. Immunol Cell Biol 1988;73:239-44.

Zhevago NA, Samoilova KA. Pro- and Anti-inflammatory Cytokine Content in Human Peripheral Blood after Its Transcutaneous (in Vivo) and Direct (in Vitro) Irradiation with Polychromatic Visible and Infrared Light. Photomed Laser Surg 2006;24:129-39.

Medenica L, Lens M. The use of ploarised polychromatic non-coherent light alone as a therapy for venous leg ulceration. J Wound Care 2003;12:37-40.

Iordanou P, Baltopoulos G, Giannakopoulou M, Bellou P, Ktenas E. Effect of polarized light in the healing process of pressure ulcers. Int J Nurs Pract 2002;8:49-55.

Charakida A, Seaton ED, Charakida M, Mouser P, Avgerinos A, Chu AC. Phototherapy in the treatment of acne vulgaris: what is its role? Am J Clin Dermatol 2004;5:211-6.

Stasinopoulos D, Stasinopoulos I. Comparison of effects of Cyriax physiotherapy, a supervised exercise programme and polarized polychromatic non-coherent light (Bioptron light) for the treatment of lateral epicondylitis. Clin Rehabil 2006;20:12-23.

Stasinopoulos D. The use of polarized polychromatic non-coherent light as therapy for acute tennis elbow/lateral epicondylalgia: a pilot study. Photomed Laser Surg 2005;23:66-9.

Stasinopoulos D, Stasinopoulos I, Johnson MI. Treatment of carpal tunnel syndrome with polarized polychromatic noncoherent light (Bioptron light): a preliminary, prospective,open clinical trial. Photomed Laser Surg 2005;23:225-8.

Huisstede BM, Hoogvliet P, Randsdorp MS, Glerum S, van Middelkoop M, Koes BW. Carpal tunnel syndrome. Part I: effectiveness of nonsurgical treatments-a systematic review. Arch Phys Med Rehabil 2010;91:981-1004.

Zhevago NA, Samoilova KA. [Modulation of proliferation of peripheral blood lymphocytes after irradiation of volunteers with polychromatic visible and infrared light].Tsitologiia 2004;46(6):567-77.

O’Connor D, Marshall S, Massy-Westropp N. Non-surgical treatment (other than steroid injection) for carpal tunnel syndrome. Cochrane Database Syst Rev 2003;(1):CD003219.

Annette A.M. Gerritsen , IBC Korthls – De Bos. Splinting for carpal tunnel syndrome: prognostic indicator of success. J NeurolNeurosurg Psych 2003;74;1342-4.

Yagci I, Elmas O, Akcan E, Ustun I, Gunduz OH, Guven Z. Comparison of splinting and splinting plus low-level laser therapy in idiopathic carpal tunnel syndrome. Clin Rheumatol 2009;28:1059-65.

Barbosa RI, da Silva Rodrigues EK, Tamanini G, Marcolino AM, Elui VM, de Jesus Guirro RR, et al. Effectiveness of low-level laser therapy for patients with carpal tunnel syndrome: design of a randomized single-blinded controlled trial. BMC Musculoskelet Disord 2012;13:248.

Reza Soltani Z, Ghayoomi AA, Raeissadat SA, Azam K, Kazempoor M, Najafi Sh. [Study of short term effects of low level laser therapy [LLLT] vs. local steroid injection on patients with carpal tunnel Syndrome]. Sci Res J Army Univ Med Sci 2008;6:91-7.

Raeissadat SA, Reza Soltani Z. Study of Long Term Effects of Laser Therapy Versus Local Corticosteroid Injection in Patients with Carpal Tunnel Syndrome. J Lasers Med Sci 2010;1:24-30.

Piazzini DB, Aprile I, Ferrara PE, Bertolini C, Tonali P, Maggi L, et al. systematic review of conservative treatment of carpal tunnel syndrome. Clin Rehabil 2007;21:299-314.

Casale R, Damiani C, Maestri R, Wells CD. Pain and electrophysiological parameters are improved by combined 830-1064 high-intensity LASER in symptomatic carpal tunnel syndrome versus Transcutaneous Electrical Nerve Stimulation. A randomized controlled study. Eur J Phys Rehabil Med 2013;49:205-11.

Rayegani SM, Bahrami MH, Eliaspour D, Raeissadat SA, Shafi Tabar Samakoosh M, Sedihgipour L, Kargozar E .The Effects of Low Intensity Laser on Clinical and Electrophysiological Parameters of Carpal Tunnel Syndrome. J Lasers Med Sci 2013;4:182-9

DOI: http://dx.doi.org/10.22037/2010.v5i1.4840