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Assessing Health-Related Quality of Life with Antimicrobial Photodynamic Therapy (APDT) and Low Level Laser Therapy (LLLT) after Third Molar Removal

Goran Batinjan, Irina Filipović Zore, Ivana Rupić, Ivona Bago Jurič, Zvonimir Zore, Dragana Gabrić Pandurić




Introduction: The purpose of this study was to evaluate the antimicrobial photodynamic therapy (APDT) and low level laser therapy (LLLT) on wound healing, pain intensity, swelling problems, halitosis and the postoperative usage of analgesics after surgical removal of lower third molars.

Methods: One hundred and fifty patients, randomly divided into three groups were selected (50 per each group). The P1 group received the APDT after a third molar surgery, the P2 group received the LLLT and the C group (control group) was without any additional therapy after surgery. A photoactive substance was applied in the APDT study group before suturing. After 60 seconds the photosensitive substance was thoroughly washed with saline water and the laser light was applied in two intervals (30 seconds each). The irradiation power was 50 mW while the wavelength was 660 nm. The laser therapy in P2 group was performed before suturing and the laser light was applied also in two intervals (90 seconds each), the irradiation power was 90 mW while the wavelength was the same as in the first group – 660 nm. Postoperative follow-ups were scheduled on the third and the seventh day in patients who received laser therapy.

Results: The results of the postoperative evaluation showed that there was a statistically significant difference in the postoperative wound healing, pain intensity, swelling problems, halitosis and analgesics intake between patients in all three groups (p<0.001). The patients that were subjected to APDT (P1) had the least postoperative problems. After the laser therapy (P1 and P2) wound healing was without any complications, opposite from the patients from the C group (p<0.001). Postoperative application of a laser therapy significantly reduced patient’s use of analgesics over the observed period of time (p<0.001).

Conclusion: Both modalities of laser therapy significantly reduced postoperative problems after surgical removal of third lower molars with the best results in both laser groups.


: low level laser therapy, photodynamic therapy, third molar extraction, postoperative complications, diode laser


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DOI: https://doi.org/10.22037/jlms.v4i3.4251