• Logo
  • SBMUJournals

The Impact of Proteomic Investigations on the Development and Improvement of Skin Laser Therapy: A review article

Shabnam Shahrokh, Zahra Razzaghi, Vahid Mansouri, Nayebali Ahmadi




Introduction: Different molecular approaches have contributed to find various response of skin to external and internal tensions such as laser irradiation and many important mediators of skin disease have been identified through these approaches. However different essential signals of skin biomarker pathways and proteins partially detected or completely unknown. In the present study impact of proteomics in the evaluation of laser therapy of skin is investigated.

Methods: Keywords of “Proteomics”, Laser therapy”, “Skin”, and “Skin disease” searched in Google Scholar, Scopus and PubMed search engines. After screening, 53 documents were included in the study.

Results: Global assessments revealed that different proteins in different signaling pathways of skin metabolism in terms of health or illness after laser therapy are expressed differentially. Results indicated that application of proteomics is a useful method to promote the results of laser interventions.

Conclusion: This kind of researches deals with practical proteomics of skin and could supply an essential skip to understand skin diseases to develop more suitable therapeutic achievements in laser application.


Protein; Skin Diseases; Proteomics; Laser therapy


Li D, Lin SB, Cheng B. Intense Pulsed Light: From the Past to the Future. Photomed Laser Surg. 2016;34(10):435-447. doi: 10.1089/pho.2016.4139.

Kohl EA, Babilas P, Landthaler M. Skin rejuvenation with intense pulsed light. Acta Dermatovenerol Croat. 2010;18(3):181-4.

DiBernardo BE, Pozner JN. Intense Pulsed Light Therapy for Skin Rejuvenation. Clin Plast Surg. 2016;43(3):535-40. doi: 10.1016/j.cps.2016.03.008.

Babilas P, Schreml S, Szeimies RM. Intense pulsed light (IPL): a review. Lasers Surg Med. 2010;42(2):93-104. doi: 10.1002/lsm.20877.

Augustyniak A, Rotsztejn H. Intense pulsed light (IPL) treatment for the skin in the eye area – clinical and cutometric analysis. J Cosmet Laser Ther. 2017;19(1):18-24. doi: 10.1080/14764172.2016.1247963.

Sadick NS, Weiss R, Kilmer S, Bitter P. Photorejuvenation with intense pulsed light: results of a multi-center study. J Drugs Dermatol. 2004;3(1):41-9.

Negishi K, Tezuka Y, Kushikata N, Wakamatsu S. Photorejuvenation for Asian skin by intense pulsed light. Dermatol Surg. 2001;27(7):627-31. doi: 10.1046/j.1524-4725.2001.01002.x.

Kligman DE, Zhen Y. Intense pulsed light treatment of photoaged facial skin. Dermatol Surg. 2004;30(8):1085-90. doi: 10.1111/j.1524-4725.2004.30332.x.

Hsu TS, Zelickson B, Dover JS, Kilmer S, Burns J, Hruza G, et al. Multicenter study of the safety and efficacy of a 585 nm pulsed-dye laser for the nonablative treatment of facial rhytides. Dermatol Surg. 2005;31(1):1-9. doi: 10.1097/00042728-200501000-00001

Hardaway CA, Ross EV, Paithankar DY. Non-ablative cutaneous remodeling with a 1.45 microm mid-infrared diode laser: phase II. J Cosmet Laser Ther. 2002;4(1):9-14. doi: 10.1080/14764170260030108.

Weiss RA, McDaniel DH, Geronemus RG, Weiss MA, Beasley KL, Munavalli GM, et al. Clinical experience with light-emitting diode (LED) photomodulation. Dermatol Surg. 2005;31(9):1199-205. doi: 10.1111/j.1524-4725.2005.31926.

Hantash BM, De Coninck E, Liu H, Gladstone HB. Split-face comparison of the erbium micropeel with intense pulsed light. Dermatol Surg. 2008;34(6):763-72. doi: 10.1111/j.1524-4725.2008.34144.x.

Cuerda-Galindo E, Díaz-Gil G, Palomar-Gallego MA, Linares-GarcíaValdecasas R. Intense pulsed light induces synthesis of dermal extracellular proteins in vitro. Lasers Med Sci. 2015;30(7):1931-9. doi: 10.1007/s10103-015-1787-5.

Bedewi AE, Khalafawy GE. The use of synchrotron infrared microspectroscopy to demonstrate the effect of intense pulsed light on dermal fibroblasts. J Cosmet Laser Ther. 2013;15(6):305-9. doi: 10.3109/14764172.2013.769271.

Faucz LL, Will SE, Rodrigues CJ, Hesse H, Moraes AC, Maria DA. Quantitative evaluation of collagen and elastic fibers after intense pulsed light treatment of mouse skin. Lasers Surg Med. 2018;50(6):622-50. doi: 10.1002/lsm.22782.

Feng Y, Zhao J, Gold MH. Skin rejuvenation in Asian skin: the analysis of clinical effects and basic mechanisms of intense pulsed light. J Drugs Dermatol. 2008;7(3):273-9.

Wong WR, Shyu WL, Tsai JW, Hsu KH, Pang JH. Intense pulsed light effects on the expression of extracellular matrix proteins and transforming growth factor beta-1 in skin dermal fibroblasts cultured within contracted collagen lattices. Dermatol Surg. 2009;35(5):816-25. doi: 10.1111/j.1524-4725.2009.01138.x.

Huang J, Luo X, Lu J, Chen J, Zuo C, Xiang Y, et al. IPL irradiation rejuvenates skin collagen via the bidirectional regulation of MMP-1 and TGF-β1 mediated by MAPKs in fibroblasts. Lasers Med Sci. 2011;26(3):381-7. doi: 10.1007/s10103-010-0870-1.

DOI: https://doi.org/10.22037/jlms.v10i4.27724