• Logo
  • SBMUJournals

Comparison and Evaluation of the Low-Level Laser and the Red and Blue LED Effects on Wound Healing in Rabbit

Marjan Ghaemi, Davood Sharifi, Soheila Mokmeli, Golshad Kowsari, Pejman Mortazavi, Pouneh Golmai
90

Views

PDF

Abstract


Introduction: Wound healing is a dynamic, interactive process to achieve the restoration of skin integrity and proper function after damage. Applying a low-level laser (LLL) and light emitting diodes (henceforth LEDs) is introduced in previous studies to accelerate the process of wound healing. The aim of this study is to compare the effect of the LLL and LEDs on wound healing in rabbits.


Methods: Full thickness same size square excision wounds were created on the dorsum of the rabbits. Twenty rabbits were randomly divided into four groups, according to the treatment received. Group 1: the AlGalInP (aluminium gallium indium phosphide) laser (4 J/cm²); group 2: the red LED (30 J/cm²); group 3: the blue LED (60 J/cm²) and group 4, as the control group, was not irradiated. After 30 days, the wounds were evaluated both morphologically and histopathologically. Statistical significance was defined as a P value of less than 0.05.


Results: All interfering methods including the LLL and LEDs had better outcome compared with the control group of both sizes and histopathologic features. The red laser group showed better results compared to the control group and either the LED groups. Comparing LEDs, the red LED performed better than the blue LED.


Conclusion: This study confirmed the significant effects of the LLL and LEDs on wound healing. Comparing the LLL and LED, the LED may be a better choice, especially for bedridden or debilitated patients. The LED may also more cost effective in wound healing in comparison with the LLL.


Keywords

Light Emitting Diode; Low-level Laser; Wound Healing

References

Singer AJ, Clark RA. Cutaneous wound healing. N Engl J Med. 1999;341(10):738-746. doi:10.1056/nejm199909023411006

Mester E, Korenyi-Both A, Spiry T, Tisza S. The effect of laser irradiation on the regeneration of muscle fibers (preliminary report). Z Exp Chir. 1975;8(4):258-262.

Mester E, Mester AF, Mester A. The biomedical effects of laser application. Lasers Surg Med. 1985;5(1):31-39.

Mester E, Spiry T, Szende B, Tota JG. Effect of laser rays on wound healing. Am J Surg. 1971;122(4):532-535.

Ribeiro MS, Da Silva Dde F, De Araujo CE, et al. Effects of low-intensity polarized visible laser radiation on skin burns: a light microscopy study. J Clin Laser Med Surg. 2004;22(1):59-66. doi:10.1089/104454704773660994

Klebanov GI, Shuraeva N, Chichuk TV, et al. A comparative study of the effects of laser and light-emitting diode irradiation on the wound healing and functional activity of wound exudate leukocytes. Biofizika. 2005;50(6):1137-1144.

Cavanagh PR, Lipsky BA, Bradbury AW, Botek G. Treatment for diabetic foot ulcers. Lancet. 2005;366(9498):1725-1735.

doi:10.1016/s0140-6736(05)67699-4

Thomas GN, Tomlinson B, Critchley JA. Guidelines for healthy weight. N Engl J Med. 1999;341(27):2097; author

reply 2098. doi:10.1056/nejm199912303412715

Maury E, Vassal T, Offenstadt G. Cardiac contractility during severe ketoacidosis. N Engl J Med. 1999;341(25):1938.

doi:10.1056/nejm199912163412516

Franklin DJ. Back to the basics. N Engl J Med. 1999;341(27):2099-2100.

Sharma OP. Back to the basics. N Engl J Med. 1999;341(27):2099. doi:10.1056/nejm199912303412717

Pryde PG, Mittendorf R. The control of labor. N Engl J Med. 1999;341(27):2098-2099. doi:10.1056/nejm199912303412716

Davis GJ. Guidelines for healthy weight. N Engl J Med. 1999;341(27):2097-2098.

Wilson WL. Guidelines for healthy weight. N Engl J Med. 1999;341(27):2097; author reply 2098.

Campion EW. Notification about early-release articles. N Engl J Med.1999;341(27):2085. doi:10.1056/nejm199912303412709




DOI: https://doi.org/10.22037/jlms.v10i3.23202