Evaluating the Efficiency of Low Level Laser Therapy (LLLT) in Combination With Intravenous Laser Therapy (IVL) on Diabetic Foot Ulcer, Added to Conventional Therapy
Journal of Lasers in Medical Sciences,
Vol. 1 No. 1 (2010),
26 April 2011
,
Page 8-13
Abstract
INTRODUCTION:: Low level laser therapy (LLLT) is gaining acceptance in clinical applications. For example, it is used as therapeutic modality in the repair of diabetic foot ulcer when conventional therapy was not effective, separately. The aim of this study is to determine the effect of local and travenous LLLT for the healing of diabetic foot ulcer.
METHODS: This study contains 74 diabetic foot-ulcers which were prone to resistance to conventional therapy. Different stages of diabetic foot are included in this study. The wounds irradiation are performed by the combination therapy of 650 nm and 860 nm laser, with the total energy density of 3.6 J/cm² plus intravenous laser therapy (IVL) with 2.5 MW, 650 nm laser used for 30 minutes. All wounds have been photographed from equal distance, before and after treatments, and all the wounds were staged by a surgeon who was disinterested and neutral about the effects of the laser therapy. Her judgments were based on the visual assessments of the wounds. All the mathematical and statistical analysis is based on the descriptive statistics which, is done by the SPSS 16.
RESULTS: in the result of this study; 62.2% (Forty-six out of the 74 ulcers) completely healed, 12.2% (Nine in numbers) healed more than 50%, 8.1% (Six in numbers) healed less than 50%, 5.4% (Four in numbers) not healed,12.2% (Nine in numbers) did not continue their treatment (less than 5 sessions of Laser therapy). Excluding, the wounds in stage 5, more than 80% of each stage’s wound, completely healed more than 50%, with in 2 months duration. In this study, we definitely can express that, all the Patients received some degrees of healing, during their laser receiving treatments.
CONCLUSION: The combined local and intravenous LLLT promote the tissue repair process of diabetic foot ulcer. In this multi-disciplinary method, we achieved a remarkably shorter mean healing time of two months, compared with other reported studies with healing time of three to six months.
- wound
- ulcer
- Diabetic
- Foot
- Laser therapy
- LLLT
- Intravenous laser therapy
How to Cite
References
Maiya GA, Kumar P, Rao L. Effect of low intensity heliumneon (He-Ne) laser irradiation on diabetic wound healing dynamics. J. Photomed Laser Surg 2005 Apr; 23(2):187-90.
Walker MD, Rumpf S, Baxter GD, Hirst DG, Lowe AS.Effect of low-intensity laser irradiation (660nm) on a radiation- impaired wound -healing model in murine skin. J Laser Surg Med 2000; 26(1):41-47.
Vladimirov IuA, et al. Mar -Apr. (2004): Molecular and cellular mechanisms of the low intensity laser radiation effect. J. Biofizika.; 49(2):339-50.
Edmonds M. Diabetic Foot Ulcers: Practical Treatment Recommendations. Drugs 2006; 66(7):913-929.
Saar WE, Lee TH, Berlet GC. The economic burden of diabetic foot and ankle disorders. Foot Ankle Int 2005; 26(1):27-31.
Singh N, Armstrong DG, Lipsky BA. Preventing foot ulcers in patients with diabetis. JAMA 2005; 293(2):217-28.
Ramachandran A. Specific problems of the diabetic foot in developing countries. Diab Metab Res Rev 1996;20(Suppl 1):S19-22.
The Diabetes Control, Complications Trial Research Group. Lifetime benefits and costs of intensive therapy as practiced in the Diabeties control and complications Trial. JAMA 1996; 276:1409-15.
Schindl A, Schindl M, Pernerstorfer-Schon H, Kerschan K, Knobler R, Schindl L. Diabetic neuropathic foot ulcer:successful treatment by low-intensity laser therapy.Dermatology 1999; 198(3):314-16.
Byrnes KR, Barna L, Chenault VM et al.Photobiomodulation improves cutaneous wound healing in an animal model of type II diabetes. Photomed Laser Surg 2004 Aug; 22(4):281-90.
Lathram P, Healing Light-Laser Technology Now Making Strides in Wound CareDiabetes health magazine.[Inernet].2001 Nov. Available from: http://www.diabeteshealth.com/ read/2001/11/01/3427/healing-light/?section=512.
Landau Z. Topical hyperbaric oxygen and low energy laser for the treatment of diabetic foot ulcer. Arch. Orthop Trauma Surg 1998;117 (3): 156 - 58.
Kujawa J, Zavodnik L, Zavodnik I, Buko V, Lapshyna A,Bryszewska M. Effect of low intensity (3.75- 2.5 J/CM2) near-infrared(810nm) laser radiation on red blood cell ATPase activities and membrane structure. J Clin Laser Med Surg 2004; 22(2):111-17.
Duan R, Liu TC, Li Y, Guo H, Yao LB. Signal transduction path ways involved in low intensity He-Ne laser induced respiratory burst in bovine neutrophils: A potential mechanism of low intensity laser biostimulation. Lasers Surg Med 2001; 29(2):174-8.
Schindl A, Schindl M, Schon H, Knobler R, Havelec L,Schindl L. Low-intensity laser irradiation improves skin circulation in patients with diabetic microangiopathy. Diab Care 1998; 21(4):580-4.
Ihsan FR. Low-level laser therapy accelerates collateral circulation and enhances microcirculation. Photomed Laser Surg 2005; 23(3):289-94.
Gal D, Chokshi SK, Mosseri M, Clarke RH, Isner JM.(1992) Percutaneous delivery of low-level laser energy reverses histamine- induced spasm in atherosclerotic Yucatan microswine. Circulation 1992 Feb; 85(2):756-68.
AR Barker, GD Rosson, AL Dellon. Wound healing in denervated tissue. Ann Plast Surg 2006; 57(3):339-342.
Brill GE, Gasparyan LV, Makela AM. Modification in relationships in the system endothelial cell- blood platelet by low level laser radiation. Paper presented at Laser Florence meeting; 2003; Florence, Italy.
Lebed’kov EV, Tolstykh PI, Marchenko LF, Turkina TI,Krivikhin VT. The effect of the laser irradiation of the blood on its lipid and phospholipid components in diabetes mellitus. Voen Med Zh. 1998 Oct; 319(10):37-8, 95.
Ramdawon P: Bioresonance information laser therapy of diabetes mellituse a first clinical experience of the hypoglycemic effect of low level laser terapy and its perspectives. Paper presented at North American Laser Therapy Association Conference; 1999 Oct; Rockville, Washington D.C., USA.
Van Acker K, De Block C, Abrams P, Bouten A, De Leeuw I, Droste J et al. The choice of diabetic foot ulcer classification in relation to the final outcome. Wounds 2002; 14: 16–25.
- Abstract Viewed: 773 times
- PDF Downloaded: 286 times