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Antimicrobial Photodynamic Therapy: An Effective Alternative Approach to Control Bacterial Infections

Hassan Mahmoudi, Abbas Bahador, Maryam Pourhajibagher, Mohammad Yousef Alikhani




Introduction: The purpose of this review was to evaluate the available literature for in vitro and in vivo effectiveness of antimicrobial Photodynamic therapy (aPDT) in the field of bacteriology.
Methods: A review of the relevant articles carried out in PubMed and Scopus to determine the efficiency of aPDT used in the reduction of microbial infection. Thirty-one relevant documents retrieved from PubMed, Scopus by inserting “antimicrobial photodynamic therapy” and “bacterial infection” and “photodynamic therapy” keywords.
Results: According to different results, aPDT can be used as an adjuvant for the treatment of infectious diseases. The use of photosensitizer methylene blue, toluidine blue O (TBO), indocyanine green with light diode laser centered at (630±10 nm) and (650±10 nm) wavelengths have been shown to have significant results for the treatment of infectious diseases and bactericidal properties
Conclusion: These findings suggest that, aPDT can be an efficient method in the treatment of localized and superficial infections.


Antimicrobial photodynamic therapy; Photosensitizer; Skin infections.


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DOI: https://doi.org/10.22037/jlms.v9i3.19113