• Logo
  • SBMUJournals

Effectiveness of Laser Acupoints on Women With Polycystic Ovarian Syndrome: A Randomized Controlled Trial

Fayiz F. Elshamy, Sand El-kholy, Marwa Abd El-Rahman
393

Views

PDF

Abstract


Introduction: Polycystic Ovary Syndrome(PCOS), one of the most common causes of infertility. The aim of this study was to investigate the impact of laser acupuncture on PCOS women.

Methods: Twenty-five PCOS women were randomly assigned to either the study group (SG; n= 13), which treated by laser acupuncture, or the control group (CG; n= 12). Blood hormonal levels and insulin resistance at baseline and after 12 weeks of intervention were measured.

Results: The pre intervention showed no statistically significant differences between SG and CG for baseline characteristics ( p>  0.05). After 12 week intervention, Within group analyses showed that BMI, blood hormonal levels and insulin resistance were significantly decreased (p< 0.05), with no significant change in FSH (p> 0.05) in the two groups. Between group analyses showed that all outcomes measures were significantly decreased (p< 0.05) in SG compared to CG, with no significant changes in FSH and BMI(p> 0.05).

Conclusion: Laser acupuncture can be suggested as an effective management for women with polycystic ovarian syndrome.

 


Keywords

Polycystic Ovary Syndrome; Blood hormonal levels; Insulin resistance; Laser; Acupuncture.

References

Azziz R, Woods KS, Reyna R, Key TJ, Knochenhauer ES, Yildiz BO. The prevalence and features of the polycystic ovary syndrome in an unselected population. J Clin Endocrinol Metab. 2004;89(6):2745-2749. doi:10.1210/ jc.2003-032046

Norman RJ, Wu R, Stankiewicz MT. 4: Polycystic ovary syndrome. Med J Aust. 2004;180(3):132-137.

Badawy A, Elnashar A. Treatment options for polycystic ovary syndrome. Int J Womens Health. 2011;3:25-35. doi:10.2147/ijwh.s11304

Stepto NK, Cassar S, Joham AE, et al. Women with polycystic ovary syndrome have intrinsic insulin resistance on euglycaemic-hyperinsulaemic clamp. Hum Reprod. 2013;28(3):777-784. doi:10.1093/humrep/des463

Azziz R, Carmina E, Dewailly D, et al. Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab. 2006;91(11):4237-4245. doi:10.1210/jc.2006-0178

Zawadski JK, Dunaif A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. In: Dunaif A, Givens JR, Haseltine FP, Merriam GR, eds. Polycystic Ovary Syndrome. 1st ed. Oxford: Blackwell Scientific Publications;1992:377-384.

Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2004;19(1):41-47.

Azziz R, Carmina E, Dewailly D, et al. The Androgen Excess and PCOS Society criteria for the polycystic ovary syndrome: the complete task force report. Fertil Steril. 2009;91(2):456-488. doi:10.1016/j.fertnstert.2008.06.035

ACOG Practice Bulletin No. 108: Polycystic ovary syndrome. Obstet Gynecol. 2009;114(4):936-949. doi:10.1097/AOG.0b013e3181bd12cb

March WA, Moore VM, Willson KJ, Phillips DI, Norman RJ, Davies MJ. The prevalence of polycystic ovary syndrome in a community sample assessed under contrasting diagnostic criteria. Hum Reprod. 2010;25(2):544-551. doi:10.1093/ humrep/dep399

Gilling-Smith C, Story H, Rogers V, Franks S. Evidence for a primary abnormality of thecal cell steroidogenesis in the polycystic ovary syndrome. Clin Endocrinol (Oxf). 1997;47(1):93-99.

Heider U, Pedal I, Spanel-Borowski K. Increase in nerve fibers and loss of mast cells in polycystic and postmenopausal ovaries. Fertil Steril. 2001;75(6):1141- 1147.

Lanham MS, Lebovic DI, Domino SE. Contemporary medical therapy for polycystic ovary syndrome. Int J Gynaecol Obstet. 2006;95(3):236-241. doi:10.1016/j. ijgo.2006.08.004

Stener-Victorin E, Waldenstrom U, Tagnfors U, Lundeberg T, Lindstedt G, Janson PO. Effects of electro-acupuncture on anovulation in women with polycystic ovary syndrome. Acta Obstet Gynecol Scand. 2000;79(3):180-188.

Whittaker P. Laser acupuncture: past, present, and future. Lasers Med Sci. 2004;19(2):69-80. doi:10.1007/s10103-004- 0296-8

Stener-Victorin E, Jedel E, Janson PO, Sverrisdottir YB. Low-frequency electroacupuncture and physical exercise decrease high muscle sympathetic nerve activity in polycystic ovary syndrome. Am J Physiol Regul Integr Comp Physiol. 2009;297(2):R387-395. doi:10.1152/ ajpregu.00197.2009

Beijing college of traditional medicine, Shanghai college of traditional medicine, Nanjing college of traditional medicine and The acupuncture institute of the academy of college of traditional medicine. Essentials of Chinese acupuncture. Beijing: Foreign languages press; 1980.

Douglas CC, Norris LE, Oster RA, Darnell BE, Azziz R, Gower BA. Difference in dietary intake between women with polycystic ovary syndrome and healthy controls. Fertil Steril. 2006;86(2):411-417. doi:10.1016/j. fertnstert.2005.12.054

Carmina E, Legro RS, Stamets K, Lowell J, Lobo RA. Difference in body weight between American and Italian women with polycystic ovary syndrome: influence of the diet. Hum Reprod. 2003;18(11):2289-2293.

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28(7):412-419. doi:10.1007/BF00280883

Burghen GA, Givens JR, Kitabchi AE. Correlation of hyperandrogenism with hyperinsulinism in polycystic ovarian disease. J Clin Endocrinol Metab. 1980;50(1):113- 116. doi:10.1210/jcem-50-1-113

Tosi F, Negri C, Perrone F, et al. Hyperinsulinemia amplifies GnRH agonist stimulated ovarian steroid secretion in women with polycystic ovary syndrome. J Clin Endocrinol Metab. 2012;97(5):1712-1719. doi:10.1210/jc.2011-2939

Taylor AE, McCourt B, Martin KA, et al. Determinants of abnormal gonadotropin secretion in clinically defined women with polycystic ovary syndrome. J Clin Endocrinol Metab. 1997;82(7):2248-2256. doi:10.1210/jcem.82.7.4105

Rebar R, Judd HL, Yen SS, Rakoff J, Vandenberg G, Naftolin F. Characterization of the inappropriate gonadotropin secretion in polycystic ovary syndrome. J Clin Invest. 1976;57(5):1320-1329. doi:10.1172/jci108400

Patel K, Coffler MS, Dahan MH, Malcom PJ, Deutsch R, Chang RJ. Relationship of GnRH-stimulated LH release to episodic LH secretion and baseline endocrine-metabolic measures in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2004;60(1):67-74.

Azziz R. Diagnostic criteria for polycystic ovary syndrome: a reappraisal. Fertil Steril. 2005;83(5):1343-1346. doi:10.1016/j.fertnstert.2005.01.085

Piltonen T, Morin-Papunen L, Koivunen R, Perheentupa A, Ruokonen A, Tapanainen JS. Serum anti-Mullerian hormone levels remain high until late reproductive age and decrease during metformin therapy in women with polycystic ovary syndrome. Hum Reprod. 2005;20(7):1820- 1826. doi:10.1093/humrep/deh850

Pasquali R, Gambineri A. Treatment of the polycystic ovary syndrome with lifestyle intervention. Current Opinion in Endocrinology, Diabetes and Obesity. 2002;9(6):459-468.

Hutchison SK, Teede HJ, Rachon D, Harrison CL, Strauss BJ, Stepto NK. Effect of exercise training on insulin sensitivity, mitochondria and computed tomography muscle attenuation in overweight women with and without

polycystic ovary syndrome. Diabetologia. 2012;55(5):1424- 1434. doi:10.1007/s00125-011-2442-8

Gambineri A, Pelusi C, Vicennati V, Pagotto U, Pasquali R. Obesity and the polycystic ovary syndrome. Int J Obes Relat Metab Disord. 2002;26(7):883-896. doi:10.1038/ sj.ijo.0801994

Harrison CL, Stepto NK, Hutchison SK, Teede HJ. The impact of intensified exercise training on insulin resistance and fitness in overweight and obese women with and without polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;76(3):351-357. doi:10.1111/j.1365-2265.2011.04160.x

Mikines KJ, Sonne B, Farrell PA, Tronier B, Galbo H. Effect of physical exercise on sensitivity and responsiveness to insulin in humans. Am J Physiol. 1988;254(3 Pt 1):E248- 259. doi:10.1152/ajpendo.1988.254.3.E248

Pasquali R, Gambineri A, Pagotto U. The impact of obesity on reproduction in women with polycystic ovary syndrome. BJOG. 2006;113(10):1148-1159. doi:10.1111/ j.1471-0528.2006.00990.x

Hollmann M, Runnebaum B, Gerhard I. Effects of weight loss on the hormonal profile in obese, infertile women. Hum Reprod. 1996;11(9):1884-1891.

El-Mekawy HS, ElDeeb AM, Ghareib HO. Effect of laser acupuncture combined with a diet-exercise intervention on metabolic syndrome in post-menopausal women. J Adv Res. 2015;6(5):757-763. doi:10.1016/j.jare.2014.08.002

Yamaura M, Yao M, Yaroslavsky I, Cohen R, Smotrich M, Kochevar IE. Low level light effects on inflammatory cytokine production by rheumatoid arthritis synoviocytes. Lasers Surg Med. 2009;41(4):282-290. doi:10.1002/ lsm.20766

Despres JP. Abdominal obesity: the most prevalent cause of the metabolic syndrome and related cardiometabolic risk. Eur Heart J Suppl. 2006;8(suppl_B):B4-B12. doi:10.1093/ eurheartj/sul002

Karu TI. Molecular mechanisms of therapeutic effects of low intensity laser radiation. Lasers Life Sci.1988;2(1):53- 74.

Sorensen SS, Christensen F, Clausen T. The relationship between the transport of glucose and cations across cell membranes in isolated tissues. X. Effect of glucose transport stimuli on the efflux of isotopically labelled calcium and 3-O-methylglucose from soleus muscles and epididymal fat pads of the rat. Biochim Biophys Acta. 1980;602(2):433- 445.

Chang R, Chung PH, Rosenwaks Z. Role of acupuncture in the treatment of female infertility. Fertil Steril. 2002;78(6):1149-1153.

Yang SP, Yu J, He L. Release of gonadotropin-releasing hormone (GnRH) from the medio-basal hypothalamus induced by electroacupuncture in conscious female rabbits. Acupunct Electrother Res. 1994;19(1):19-27.

Aso T, Motohashi T, Murata M, Nishimura T, Kakizaki K. The influence of acupuncture stimulation on plasma levels of LH, FSH, progesterone and estradiol in normally ovulating women. Am J Chin Med (Gard City N Y). 1976;4(4):391-401.

Stener-Victorin E, Waldenstrom U, Andersson SA, Wikland M. Reduction of blood flow impedance in the uterine arteries of infertile women with electro-acupuncture. Hum Reprod. 1996;11(6):1314-1317.

Olausson H, Lamarre Y, Backlund H, et al. Unmyelinated tactile afferents signal touch and project to insular cortex. Nat Neurosci. 2002;5(9):900-904. doi:10.1038/nn896