متاآنالیز مرگ ناشي از سرطان كليه در بين کارگران توليد كننده و در تماس مزمن با تركيبات کلروفنلChronic exposure to chlorophenol related compounds in production workplace and kidney cancer: A meta-analysis

رضوان زنده دل, رعنا طايفه رحيميان, علي كبير

138

چکیده

ABSTRACT

Background and Aims: Chlorophenols are a group of pesticides contaminated with dioxin compounds during

their manufacturing. The International Agency for Research on Cancer (IARC) demonstrated an association

between dioxin exposure and lung cancer, non-Hodgkin lymphoma, and soft-tissue sarcoma but the risk of

kidney cancer and dioxin exposure has not been clearly defined. This study was proposed a meta-analysis of

published researches to evaluate relationship between chronic chlorophenols exposure in pesticide production

workplace and the mortality risk of kidney cancer.

Materials and Methods:″chlorophenol″, ″Phenoxyacetic acid″ ,″cancer″ and ″dioxin″ keywords were used

in PubMed, Embase, Science Direct, Ovid, Google Scholar, and Medline until 2012 and all publications that

investigated the association between chroniccholophenols exposure in the production workplace and kidney

cancer were identified. Publication bias was evaluated based on Egger test and funnel plot. We evaluated the

heterogeneity of the studies with Q test. Random-effects model of DerSimonian Laird method was conducted

in heterogenic studies, otherwise fixed-effects model based on Mentel-Henzel random-effects model was used.

Results: Our search yielded 27 papers which investigated the association between chronic cholophenols

exposure in the production workplace and cancer. After reviewing these papers 7 publications without

overlapping represented standardized mortality rate (SMR) of kidney cancer. Results of metaanalysis showed

that SMR for kidney cancer in workers with cholophenols exposure was increased (SMR: 1.25 ,95% CI: 0.9-

1.63, p = 0.09).

Conclusions: The results of this study strengthen the evidence of cancer in occupational exposure to

cholophenols contaminated with TCDD. Moreover, these compounds increased the risk of death from kidney

cancer which was related to the type of cholophenols compound and dioxine contamination.

Key words: Chlorophenol, Dioxine, Meta-Analysis, Kidney Cancer.

*Corresponding Author:

MD, MPH, PhD Candidate of Epidemiology, Department of Epidemiology, Faculty of Public Health, Shahid Beheshti

University of Medical Sciences, Tehran, Iran

Email: aikabir@yahoo.com

Received: 24 Nov. 2013

Accepted: 13 Jan. 2014


تمام متن:

PDF

ارجاعات

  • در حال حاضر ارجاعی نیست.