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Supplemental Oxygen therapy and Non-Invasive Ventilation in Corona Virus Disease (COVID-19)

Soudeh Tabashi, Alireza Mirkheshti, Mastaneh Dahi, Dariush Abtahi, Maryam Vosoughian, Shahram Sayyadi, Mohammadreza Moshari, Elham Memary, Shideh Dabir, Sohrab Salimi, Ardeshir Tajbakhsh




The world has experienced a pandemic due to novel Severe Acute Respiratory Disease Corona Virus-2 (SARS-CoV2) since December 2019. The clinical spectrum of the disease known as Coronavirus Disease 2019 (COVID-19) is so much wide, starting from an asymptomatic state to paucisymptomatic clinical presentation, pneumonia, respiratory failure to even death. Supplemental oxygen therapy is essential in managing COVID-19. Also, there is sparse evidence regarding use of non-invasive ventilation (NIV) in pandemics like SARS-CoV-2. This study reviews the currently available methods for respiratory support in COVID-19 with a discussion about using these modalieties in the COVID-19 pandemic.


Coronavirus, COVID-19, Non-invasive Ventilation, Oxygenation, Supplemental oxygen therapy, High Flow Nasal Oxygenation


WHO. Coronavirus disease (COVID-19) Pandemic 2020 [updated 28 March 2020, 01:42 GMT+4:30. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019.

Zhou F, Yu T, Du R, Fan G, Liu Y, Liu Z, et al. Clinical course and risk factors for mortality of adult inpatients with COVID-19 in Wuhan, China: a retrospective cohort study. Lancet. 2020. 395(10229):1054-62

Sun Q, Qiu H, Huang M, Yang Y. Lower mortality of COVID-19 by early recognition and intervention: experience from Jiangsu Province. Ann Intensive Care. 2020;10(1):33.

Becker DE, Rosenberg MB, Phero JC. Essentials of airway management, oxygenation, and ventilation: part 1: basic equipment and devices. Anesth Prog. 2014;61(2):78-83.

Xu Z, Shi L, Wang Y, Zhang J, Huang L, Zhang C, et al. Pathological findings of COVID-19 associated with acute respiratory distress syndrome. Lancet Respir Med. 2020;8(4):420-422.

Mehta S, Hill NS. Noninvasive ventilation in acute respiratory failure. Respir Care Clin N Am. 1996;2(2):267-92.

Bello G, De Santis P, Antonelli M. Non-invasive ventilation in cardiogenic pulmonary edema. Ann Transl Med. 2018;6(18):355.

Cook TM, El-Boghdadly K, McGuire B, McNarry AF, Patel A, Higgs A. Consensus guidelines for managing the airway in patients with COVID-19: Guidelines from the Difficult Airway Society, the Association of Anaesthetists the Intensive Care Society, the Faculty of Intensive Care Medicine and the Royal College of Anaesthetists. Anaesthesia. 2020 Mar 27. doi: 10.1111/anae.15054.

Greenland JR, Michelow MD, Wang L, London MJ. COVID-19 Infection: Implications for Perioperative and Critical Care Physicians. Anesthesiology. 2020. [Epub ahead of print]

Singh V, Gupta P, Khatana S, Bhagol A. Supplemental oxygen therapy: Important considerations in oral and maxillofacial surgery. Natl J Maxillofac Surg. 2011;2(1):10-4.

Nishimura M. High-flow nasal cannula oxygen therapy in adults. J Intensive Care. 2015 31;3(1):15.

Guan WJ, Ni ZY, Hu Y, Liang WH, Ou CQ, He JX, et al. Clinical Characteristics of Coronavirus Disease 2019 in China. N Engl J Med. 2020.

Bateman NT, Leach RM. ABC of oxygen. Acute oxygen therapy. BMJ. 1998;317(7161):798-801.

Siemieniuk RAC, Chu DK, Kim LH, Guell-Rous MR, Alhazzani W, Soccal PM, et al. Oxygen therapy for acutely ill medical patients: a clinical practice guideline. BMJ. 2018;363:k4169.

Sun YH, Dai B, Peng Y, Tan W, Zhao HW. Factors affecting FiO2 and PEEP during high-flow nasal cannula oxygen therapy: A bench study. Clin Respir J. 2019;13(12):758-64.

Murthy S, Gomersall CD, Fowler RA. Care for Critically Ill Patients With COVID-19. JAMA. 2020 Mar 11. doi: 10.1001/jama.2020.3633. [Epub ahead of print].

Ramsay M, Hart N. Current opinions on non-invasive ventilation as a treatment for chronic obstructive pulmonary disease. Curr Opin Pulm Med. 2013;19(6):626-30.

Namendys-Silva, S. A. Respiratory support for patients with COVID-19 infection. Lancet Respir Med. 2020;8(4):e18.

Xie, J., Tong, Z., Guan, X. et al. Critical care crisis and some recommendations during the COVID-19 epidemic in China. Intensive Care Med (2020).

Bello G, De Santis P, Antonelli M. Non-invasive ventilation in cardiogenic pulmonary edema. Ann Transl Med. 2018;6(18):355.

Masip J, Peacock WF, Price S, Cullen L, Martin-Sanchez FJ, Seferovic P, et al. Indications and practical approach to non-invasive ventilation in acute heart failure. Eur Heart J. 2018;39(1):17-25.

Mehta S, Hill NS. Noninvasive ventilation. Am J Respir Crit Care Med. 2001;163(2):540-77.

Addala D, Shrimanker R, Davies M. Non-invasive ventilation: initiation and initial management. Br J Hosp Med (Lond). 2017;78(9):C140-C144.

Rochwerg B, Brochard L, Elliott MW, Hess D, Hill NS, Nava S, et al. Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure. Eur Respir J. 2017;50(2).

Deng Y, Liu W, Liu K, Fang YY, Shang J, Zhou L, et al. Clinical characteristics of fatal and recovered cases of coronavirus disease 2019 (COVID-19) in Wuhan, China: a retrospective study. Chin Med J (Engl). 2020.

Chan KW, Wong VT, Tang SCW. COVID-19: An Update on the Epidemiological, Clinical, Preventive and Therapeutic Evidence and Guidelines of Integrative Chinese-Western Medicine for the Management of 2019 Novel Coronavirus Disease. Am J Chin Med. 2020:1-26.

Cheung JC, Ho LT, Cheng JV, Cham EYK, Lam KN. Staff safety during emergency airway management for COVID-19 in Hong Kong. Lancet Respir Med. 2020;8(4):e19.

Cascella M, Rajnik M, Cuomo A, C. DS, Di Napoli R. Features, Evaluation and Treatment Coronavirus (COVID-19). In: StatPearls [Internet] Treasure Island (FL): StatPearls Publishing; 2020 Jan- 2020.

DOI: https://doi.org/10.22037/jcma.v5i1.29689


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