• Logo
  • SBMUJournals

Prevalence of Rare and Common Bleeding Disorders in Kurdistan Province of Iran

Akbar Dorgalaleh, Jamal Rashid Panah, Bijan Varmaghani, Peyman Beigi, Abbas Ahmadi
2

Views

PDF

Abstract

Background: Congenital bleeding disorders (CBD) are a group of coagulopathies with different clinical and laboratory features. The prevalence of these disorders in different parts of the world is variable. Iran as a country with a high rate of parental consanguinity has a high rate of CBDs. This study was to report the prevalence of these disorders in Kurdistan province, west of Iran.

Methods and materials: This descriptive study was conducted on patients suspected of a congenital bleeding disorder referred to hemophilia center of this province for evaluation of underlying bleeding diathesis. Diagnosis and classification of disorders were made by routine and specific laboratory tests.

Results: Out of 107 patients, 65.4% affected by common bleeding disorders (hemophilia A and B), 23.4% affected by rare bleeding disorders (RBDs) and 11.2% had inherited platelet disorders. Factor VII deficiency (64%) was the most common RBDs and 9 patients had von Willebrand disease. Out of three patients with inherited platelet disorders, two had Glanzmann thrombasthenia.

Conclusion: CBD pattern though has similar patterns with total pattern of the country, some of the inherited platelet disorders are more common in Kurdish province. Determination of prevalence and distribution of these disorders can improve health system planning and resource allocation.

Keywords: Congenital bleeding disorders, Rare bleeding disorders, Common bleeding disorders, inherited platelet disorders


Keywords

Congenital bleeding disorders, Rare bleeding disorders, Common bleeding disorders, Inherited platelet disorders

References

Kizilocak H, Yukhtman CL, Marquez-Casas E, Lee J, Donkin J, Young G. Management of perioperative hemostasis in a severe hemophilia A patient with inhibitors on emicizumab using global hemostasis assays. Ther Adv Hematol. 2019 Jun 27;10:2040620719860025.

James P, Salomon O, Mikovic D, Peyvandi F. Rare bleeding disorders - bleeding assessment tools, laboratory aspects and phenotype and therapy of FXI deficiency. Haemophilia. 2014: Suppl 4:71-5.

Dorgalaleh A, Tabibian S, Shamsizadeh M. Inherited Platelet Function Disorders (IPFDs). Clin Lab. 2017;63(1):1-13.

Eshghi P, Mahdavi-Mazdeh M, Karimi M, Aghighi M. Haemophilia in the developing countries: the Iranian experience. Arch Med Sci. 2010 Mar 1;6(1):83-9.

Kumar S, Sinha S, Bharti A, Meena LP, Gupta V, Shukla J. A study to determine the prevalence, clinical profile and incidence of formation of inhibitors in patients of hemophilia in North Eastern part of India. J Family Med Prim Care. 2019;8(7):2463-2467.

Mehdizadeh M, Kardoost M, Zamani G, Baghaeepour MR, Sadeghian K, Pourhoseingholi MA. Occurrence of haemophilia in Iran. Haemophilia. 2009;15(1):348-51.

Mansouritorghabeh H, Manavifar L, Banihashem A, Modaresi A, Shirdel A, Shahroudian M, Shoja-E-Razavi G, Pousti H, Esmaily H.. An investigation of the spectrum of common and rare inherited coagulation disorders in north-eastern Iran. Blood Transfus. 2013;11(2):233-40.

Dorgalaleh A, Dadashizadeh G, Bamedi T. Hemophilia in Iran. Hematology. 2016;21(5):300-10.

Karimi M, Haghpanah S, Amirhakimi A, Afrasiabi A, Dehbozorgian J, Nasirabady S. Spectrum of CBDs in southern Iran, before and after the establishment of comprehensive coagulation laboratory. Blood Coagul Fibrinolysis. 2009;20(8):642-5.

Mannucci PM, Duga S, Peyvandi F. Recessively inherited coagulation disorders. Blood. 2004;104(5):1243-52.

Dorgalaleh A, Alavi SER, Tabibian S, Soori S, Moradi Eh, Bamedi T, Asadi M, Jalalvand M, Shamsizadeh M. Diagnosis, clinical manifestations and management of rare bleeding disorders in Iran. Hematology. 2017;22(4):224-230.

Naderi M, Tabibian S, Shamsizadeh M, Dorgalaleh A. Miscarriage and recurrent miscarriage in patients with congenital factor V deficiency: a report of six cases in Iran. Int J Hematol. 2016;103(6):673-5.




DOI: https://doi.org/10.22037/jcma.v4i4.29074

Refbacks

  • There are currently no refbacks.