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Effect of Intravenous Infusion of Lidocaine on Pain Reduction after Cesarean Section under General Anesthesia

Anahita Hirmanpour, Reihanak Talakoub, Hamed Mansouri
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Abstract

Background: The present study was conducted to evaluate the effect of Lidocaine on pain reduction during and ileus and the need for opioids after caesarean section.

Methods: For this randomized double-blind controlled clinical trial, 40 ASA I, II pregnant women who were candidates for caesarean section with general anesthesia, were randomly allocated into two groups of Lidocaine receivers and placebo using randomized block design; the Lidocaine group received 1.5 mg/kg of Lidocaine right before the surgery and then its infusion with a dose of 2 mg/kg.h until the end of the surgery and the placebo group received normal saline with the same volume and application. Patients’ pain intensity was measured using numerical rating scale (NRS), 0 (entering the recovery), 0.5, 1, 4, 12 and 24 hours after the surgery.

Results: Lidocaine decreased the systolic and diastolic pressures of the patients only during the first minute after intubation, decreased the mean of arterial blood pressure at the 10th minute after intubation and 40th minute after surgery, and also decreased the mean of patients’ pain intensity, Diclofenac and Pethidine consumption, side effects (nausea and vomiting) and reduced the time interval before the first time of tolerating oral liquids; but it had effect on infants’ Apgar score 1 and 5 minutes after delivery.

Conclusions: Lidocaine was definitely effective on reducing the intensity of pain, opioid and non-steroidal anti-inflammatory drugs consumption and ileus after surgery with the least occurrence of side effects for mothers and infants.


Keywords

Caesarean Section; Postoperative Pain; Lidocaine; General Anesthesia

References

Sekhavat L, Behdad S. Preoperative analgesia with local lidocaine for cesarean delivery pain relief. The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet. 2011;24(7):891-3.

Navali N, Fouladi RF, Nikpour MA. A comparison of post-incisional subcutaneous, intramuscular, and subcutaneous plus intramuscular infiltrations of lidocaine in post-caesarean pain control2012.

Pan MDPeter H, Coghill PDR, Houle PDTimothy T, Seid MDMelvin H, Lindel MDW M, Parker MDR L, et al. Multifactorial Preoperative Predictors for Postcesarean Section Pain and Analgesic Requirement. Anesthesiology. 2006;104(3):417-25.

Shahin AY, Osman AM. Intraperitoneal lidocaine instillation and postcesarean pain after parietal peritoneal closure: a randomized double blind placebo-controlled trial. The Clinical journal of pain. 2010;26(2):121-7.

Tan HL, Lie KI. Treatment of tachyarrhythmias during pregnancy and lactation. European heart journal. 2001;22(6):458-64.

Chow T, Galvin J, McGovern B. Antiarrhythmic drug therapy in pregnancy and lactation. The American journal of cardiology. 1998;82(4a):58i-62i.

Kaba A, Laurent SR, Detroz BJ, Sessler DI, Durieux ME, Lamy ML, et al. Intravenous lidocaine infusion facilitates acute rehabilitation after laparoscopic colectomy. Anesthesiology. 2007;106(1):11-8; discussion 5-6.

Moiniche S, Kehlet H, Dahl JB. A qualitative and quantitative systematic review of preemptive analgesia for postoperative pain relief: the role of timing of analgesia. Anesthesiology. 2002;96(3):725-41.

Kaufman E, Epstein JB, Gorsky M, Jackson DL, Kadari A. Preemptive analgesia and local anesthesia as a supplement to general anesthesia: a review. Anesthesia progress. 2005;52(1):29-38.

El-Tahan MR, Warda OM, Diab DG, Ramzy EA, Matter MK. A randomized study of the effects of perioperative i.v. lidocaine on hemodynamic and hormonal responses for cesarean section. Journal of anesthesia. 2009;23(2):215-21.

Kord Valeshabad A, Nabavian O, Nourijelyani K, Kord H, Vafainejad H, Kord Valeshabad R, et al. Attenuation of Hemodynamic Responses to Laryngoscopy and Tracheal Intubation: Propacetamol versus Lidocaine-A Randomized Clinical Trial. Anesthesiology research and practice. 2014;2014:170247.

Qi DY, Wang K, Zhang H, Du BX, Xu FY, Wang L, et al. Efficacy of intravenous lidocaine versus placebo on attenuating cardiovascular response to laryngoscopy and tracheal intubation: a systematic review of randomized controlled trials. Minerva anestesiologica. 2013;79(12):1423-35.

Barreveld A, Witte J, Chahal H, Durieux ME, Strichartz G. Preventive analgesia by local anesthetics: the reduction of postoperative pain by peripheral nerve blocks and intravenous drugs. Anesthesia and analgesia. 2013;116(5):1141-61.

Alvey EN, Ching Y-H, Karlnoski RA, Dalvi PH, Murr MM, Mangar D, et al. Systemic intraoperative lidocaine infusion for postoperative pain management in obese patients: A randomized, placebo controlled pilot study. Case Studies in Surgery. 2016;2(4):p10.

Marret E, Rolin M, Beaussier M, Bonnet F. Meta‐analysis of intravenous lidocaine and postoperative recovery after abdominal surgery. British Journal of Surgery. 2008;95(11):1331-8.

Koppert W, Weigand M, Neumann F, Sittl R, Schuettler J, Schmelz M, et al. Perioperative intravenous lidocaine has preventive effects on postoperative pain and morphine consumption after major abdominal surgery. Anesthesia & Analgesia. 2004;98(4):1050-5.

Groudine SB, Fisher HA, Kaufman RP, Patel MK, Wilkins LJ, Mehta SA, et al. Intravenous lidocaine speeds the return of bowel function, decreases postoperative pain, and shortens hospital stay in patients undergoing radical retropubic prostatectomy. Anesthesia & Analgesia. 1998;86(2):235-9.

Grigoras A, Lee P, Sattar F, Shorten G. Perioperative intravenous lidocaine decreases the incidence of persistent pain after breast surgery. The Clinical journal of pain. 2012;28(7):567-72.

Saadawy I, Kaki A, Abd El Latif A, ABD‐ELMAKSOUD A, Tolba O. Lidocaine vs. magnesium: effect on analgesia after a laparoscopic cholecystectomy. Acta Anaesthesiologica Scandinavica. 2010;54(5):549-56.

Tikuišis R, Miliauskas P, Samalavičius N, Žurauskas A, Samalavičius R, Zabulis V. Intravenous lidocaine for post-operative pain relief after hand-assisted laparoscopic colon surgery: a randomized, placebo-controlled clinical trial. Techniques in coloproctology. 2014;18(4):373-80.

McCarthy GC, Megalla SA. Impact of intravenous lidocaine infusion on postoperative analgesia and recovery from surgery. Drugs. 2010;70(9):1149-63.

Vigneault L, Turgeon AF, Côté D, Lauzier F, Zarychanski R, Moore L, et al. Perioperative intravenous lidocaine infusion for postoperative pain control: a meta-analysis of randomized controlled trials. Canadian Journal of Anesthesia/Journal canadien d'anesthésie. 2011;58(1):22-37.

Reddi D, Curran N. Chronic pain after surgery: pathophysiology, risk factors and prevention. Postgraduate medical journal. 2014:postgradmedj-2013-132215.




DOI: https://doi.org/10.22037/jcma.v3i1.16045

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