The predicting values of Pao2/Fio2 ratio in survival of neonates with Congenital Diaphragmatic Hernia

Mohamad Hadi Rafeie--- Pediatric surgery department, Medical University of Isfahan, Isfahan,
Mahdi Musavi--- Medical University of Isfahan, Isfahan,
Bahareh Ahmadi--- Clinical Research and Development department of Imam Hossein children hospital, Isfahan,
Mehrdad Hosseinpour--- Pediatric surgery department, Medical University of Isfahan, Isfahan




Respiratory failure is one of the most important related factors to morbidity and high mortality in neonates with congenital diaphragmatic hernia (CDH). Determining indices that could ultimately and perceively predict the disease severity, prognosis and morbidity of these neonates is crucial.


This study aimed to evaluate the predictive value of Pao2/Fio2 ratio (P/F ratio) in neonates with CDH.

Methods and Materials

In a retrospective study, documents of all neonates with CDH that admitted to Alzahra hospital, Isfahan, Iran were checked from 2005 to 2015. 35 neonates with CDH were studied. Data such as gestational age, sex, weight, Pao2, Fio2 and the outcome of the neonate were collected.


In this survey 28 neonates with CDH were studied. The mean P/F ratio in the live group was 2.12 ±0.90 and in the death group 1.38± 0.48. According to these results the P/F ratio in the live group was higher than the other group and this difference was statistically significant (P= 0.02). Results showed that the specificity of P/F ratio in predict of the live neonates is 72.2 percent and its sensitivity in predicting the dead neonates is 80 percent.  


P/F ratio can be used as an index for predicting the survival of neonates with CDH.


Neonate, survival, Pao2/Fio2 ratio, congenital diaphragmatic hernia

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