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Trichomonas vaginalis Pathogenesis: a Narrative Review

Zahra Arab-Mazar, Maryam Niyyati
2063

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Abstract

In the latest articles which were published during 2013-2014, Trichomonas vaginalis (T. vaginalis) was mentioned as a neglected sexual transmission disease (STD), while the exact mechanism of its pathogenesis has not been cleared yet. Although trichomonasiasis is easy curable, there is concern that resistance to drug are increasing. This common infection as concerning the important public health implications needs more research to be done for understanding the diagnosis, treatment, immunology and pathogenesis. In this review we searched all valuable and relevant information considering the pathogenesis of T. vaginalis. We referred to the information databases of Medline, PubMed, Scopus and Google scholar. The used keywords were the combinations of T. vaginalis and words associated with pathogenicity. This review discusses the host-parasite interaction and pathogenicity of this parasite.


Keywords

Trichomonas vaginalis , Pathogenesis, STD

References

Bachmann LH, Lewis I, Allen R, Schwebke JR, Leviton LC, Siegal HA, et al. Risk and prevalence of treatable sexually transmitted diseases at a Birmingham substance abuse treatment facility. Am J Public Health. 2000; 90(10):1615-8.

Bhatt R, Abraham M, Petrin D, Garber G E. New concepts in the diagnosis and pathogenesis of Trichomonas vaginalis. The Canadian Journal of Infectious Diseases. 1996;7(5):321.

Burgess D. Trichomonads and intestinal flagellates. Topley and Wilson’s microbiology and microbial infections. 1998;5:203-14.

Nielson MH, Nielson R. Electron microscopy of Trichomonas vaginalis Donne: interaction with vaginal epithelium in human trichomoniasis. Acta Pathologica Microbiologica Scandinavica Section B Microbiology. 1975;83(4):305-20.

Honigberg B, King V. Structure of Trichomonas vaginalis Donne. The Journal of parasitology. 1964;345-64.

Lindmark DG, Müller M. Hydrogenosome, a cytoplasmic organelle of the anaerobic flagellate Tritrichomonas foetus, and its role in pyruvate metabolism. Journal of Biological Chemistry. 1973;248(22):7724-8.

Nielsen MH. In vitro effect of metronidazole on the ultrastructure of Trichomonas vaginalis Donné. Acta Pathologica Microbiologica Scandinavica Section B Microbiology. 1976;84(2):93-100.

Schwebke JR, Venglarik MF, Morgan SC. Delayed versus immediate bedside inoculation of culture media for diagnosis of vaginal trichomonosis. Journal of clinical microbiology. 1999;37(7):2369-70.

Cates W. Estimates of the incidence and prevalence of sexually transmitted diseases in the United States. American Social Health Association Panel. Sex Transm Dis. 1999;26(4 Suppl):2-7.

Ziaei Hezarjaribi H, Fakhar M, Shokri A, Hosseini Teshnizi S, Sadough A, Taghavi M. Trichomonas vaginalis infection among Iranian general population of women: a systematic review and meta-analysis. Parasitol Res. 2015;114(4):1291-300.

James JA, Thomason JL, Gelbart SM, Osypowski P, Kaiser P, Hanson L. Is trichomoniasis often associated with bacterial vaginosis in pregnant adolescents? Am J Obstet Gynecol. 1992;166(3):859-63.

Thomason J, Gelbart S, Sobun J, Schulien M, Hamilton P. Comparison of four methods to detect Trichomonas vaginalis. Journal of clinical microbiology. 1988;26(9):1869-70.

Wolner-Hanssen P, Krieger JN, Stevens CE, Kiviat NB, Koutsky L, Critchlow C, et al. Clinical manifestations of vaginal trichomoniasis. JAMA. 1989;261(4):571-6.

Hesseltine H C, Wolters S, Campbell A. Experimental human vaginal trichomoniasis. The Journal of Infectious Diseases. 1942:127-30.

Cotch M. Effects of Trichomonas vaginalis carriage on pregnancy outcome. International Society for STD Research. Banff Alta. 1991.

Choromanski L, Beat D A, Nordin JH, Pan AA, Honigberg B M. Further studies on the surface saccharides in Trichomonas vaginalis strains by fluorescein-conjugated lectins. Z Parasitenkd. 1985;71(4):443-58.

Honigberg BM, Livingston MC, Frost JK. Pathogenicity of fresh isolates of Trichomonas vaginalis: "the mouse assay" versus clinical and pathologic findings. Acta Cytol. 1966;10(5):353-61.

Honigberg B M, Gupta P K, Spence M R, Frost J K, Kuczynska K, Choromanski L, et al. Pathogenicity of Trichomonas vaginalis: cytopathologic and histopathologic changes of the cervical epithelium. Obstet Gynecol. 1984;64(2):179-84.

Sharma NN, Honigberg BM. Cytochemical observations on chick liver cell cultures infected with Trichomonas vaginalis. 1. Nucleic acids, polysaccharides, lipids, and proteins. J Parasitol. 1966;52(3):538-55.

Sharma N N , Honigberg B M. Cytochemical observations on malic dehydrogenase, lipase, nonspecific esterase and monoamine oxidase in chick liver cell cultures infected with Trichomonas vaginalis. J Protozool. 1969;16(1):171-81.

Sharma N, Honigberg B. Cytochemical observations on glucose-6-phosphatase, glucosan phosphorylase, glucose-6-phosphate dehydrogenase, and α-glycerophosphate dehydrogenase in chick liver cell cultures infected with Trichomonas vaginalis. International journal for parasitology. 1971;1(1):67-83.

Pindak F F, Mora de Pindak M, Gardner W A, Jr. Contact-independent cytotoxicity of Trichomonas vaginalis. Genitourin Med. 1993;69(1):35-40.

Graves A, Gardner WA. Pathogenicity of Trichomonas vaginalis. Clin Obstet Gynecol. 1993;36(1):145-52.

Garber GE, Lemchuk-Favel LT, Bowie WR. Isolation of a cell-detaching factor of Trichomonas vaginalis. J Clin Microbiol. 1989;27(7):1548-53.

Alderete JF, Garza GE. Specific nature of Trichomonas vaginalis parasitism of host cell surfaces. Infect Immun. 1985;50(3):701-8.

Alderete JF, Pearlman E. Pathogenic Trichomonas vaginalis cytotoxicity to cell culture monolayers. Br J Vener Dis. 1984;60(2):99-105.

Heath J P. Behaviour and pathogenicity of Trichomonas vaginalis in epithelial cell cultures: a study by light and scanning electron microscopy. Br J Vener Dis. 1981;57(2):106-17.

Krieger JN, Ravdin JI, Rein MF. Contact-dependent cytopathogenic mechanisms of Trichomonas vaginalis. Infect Immun. 1985;50(3):778-86.

Arroyo R, Gonzalez-Robles A, Martinez-Palomo A, Alderete J F. Signalling of Trichomonas vaginalis for amoeboid transformation and adhesion synthesis follows cytoadherence. Mol Microbiol. 1993;7(2):299-309.

Mendoza-Lopez MR, Becerril-Garcia C, Fattel-Facenda LV, Avila-Gonzalez L, Ruiz-Tachiquin M E, Ortega-Lopez J, et al. CP30, a cysteine proteinase involved in Trichomonas vaginalis cytoadherence. Infect Immun. 2000;68(9):4907-12.

Bonilha VL, Ciavaglia Mdo C, de Souza W, Costa e Silva Filho F. The involvement of terminal carbohydrates of the mammalian cell surface in the cytoadhesion of trichomonads. Parasitol Res. 1995;81(2):121-6.

Alderete JF, Garza GE. Identification and properties of Trichomonas vaginalis proteins involved in cytadherence. Infect Immun. 1988;56(1):28-33.

Arroyo R, Alderete JF. Trichomonas vaginalis surface proteinase activity is necessary for parasite adherence to epithelial cells. Infect Immun. 1989;57(10):2991-7.

Alderete J F, O'Brien J L, Arroyo R, Engbring J A, Musatovova O, Lopez O, et al. Cloning and molecular characterization of two genes encoding adhesion proteins involved in Trichomonas vaginalis cytoadherence. Mol Microbiol. 1995;17(1):69-83.

O'Brien JL, Lauriano CM, Alderete JF. Molecular characterization of a third malic enzyme-like AP65 adhesin gene of Trichomonas vaginalis. Microb Pathog. 1996;20(6):335-49.

Alderete JF, Arroyo R, Dailey DC, Engbring J, Khoshnan MA, Lehker MW, et al. Molecular analysis of Trichomonas vaginalis surface protein repertoires. Mol Cell Biol Hum Dis Ser. 1992;1:173-202.

Lehker MW, Arroyo R, Alderete JF. The regulation by iron of the synthesis of adhesins and cytoadherence levels in the protozoan Trichomonas vaginalis. J Exp Med. 1991;174(2):311-8.

Tsai CD, Liu HW, Tai JH. Characterization of an iron-responsive promoter in the protozoan pathogen Trichomonas vaginalis. J Biol Chem. 2002;277(7):5153-62.

Rasmussen SE, Nielsen MH, Lind I, Rhodes JM. Morphological studies of the cytotoxicity of Trichomonas vaginalis to normal human vaginal epithelial cells in vitro. Genitourin Med. 1986;62(4):240-6.

Benchimol M, Batista C, De Souza W. Fibronectin- and laminin-mediated endocytic activity in the parasitic protozoa Trichomonas vaginalis and Tritrichomonas foetus. J Submicrosc Cytol Pathol. 1990;22(1):39-45.

Casta e Silva Filho F, de Souza W, Lopes J D. Presence of laminin-binding proteins in trichomonads and their role in adhesion. Proc Natl Acad Sci U S A. 1988;85(21):8042-6.

Peterson K M, Alderete JF. Host plasma proteins on the surface of pathogenic Trichomonas vaginalis. Infect Immun. 1982;37(2):755-62.

Peterson KM, Alderete JF. Trichomonas vaginalis is dependent on uptake and degradation of human low density lipoproteins. J Exp Med. 1984;160(5):1261-72.

Peterson K, Baseman JB, Alderete J F. Molecular cloning of Treponema pallidum outer envelope fibronectin binding proteins, P1 and P2. Genitourin Med. 1987;63(6):355-60.

Thomas DD, Baseman JB, Alderete JF. Fibronectin mediates Treponema pallidum cytadherence through recognition of fibronectin cell-binding domain. J Exp Med. 1985;161(3):514-25.

Gold D, Ofek I. Adhesion of Trichomonas vaginalis to plastic surfaces: requirement for energy and serum constituents. Parasitology. 1992;10 (Pt 1):55-62.

Krieger JN, Wolner-Hanssen P, Stevens C, Holmes KK. Characteristics of Trichomonas vaginalis isolates from women with and without colpitis macularis. J Infect Dis. 1990;161(2):307-11.

Silva-Filho FC, Kasai S, Nomizu M, Lopez LB, Melo-Braga MB, Rocha-Azevedo B, et al. How laminin-1 can be recognized by the protozoan parasite Tritrichomonas foetus: possible role played by the extracellular matrix glycoprotein in both cytoadhesion and cytotoxicity exerted by the parasite. Parasitol Int. 2002;51(3):305-7.

Lehker MW, Chang TH, Dailey DC, Alderete JF. Specific erythrocyte binding is an additional nutrient acquisition system for Trichomonas vaginalis. J Exp Med. 1990;171(6):2165-70.

Dailey DC, Chang TH, Alderete JF. Characterization of Trichomonas vaginalis haemolysis. Parasitology. 1990;101(Pt 2):171-5.

Fiori PL, Rappelli P, Rocchigiani AM, Cappuccinelli P. Trichomonas vaginalis haemolysis: evidence of functional pores formation on red cell membranes. FEMS Microbiol Lett. 1993;109(1):13-8.

Krieger J N, Poisson M A, Rein M F. Beta-hemolytic activity of Trichomonas vaginalis correlates with virulence. Infect Immun 1983; 41(3): 1291-5.

North MJ. Comparative biochemistry of the proteinases of eucaryotic microorganisms. Microbiol Rev. 1982;46(3):308-40.

North MJ. Cysteine endopeptidases of parasitic protozoa. Methods Enzymol. 1994;244:523-39.

Irvine JW, Coombs GH, North MJ. Purification of cysteine proteinases from trichomonads using bacitracin-Sepharose. FEMS Microbiol Lett. 1993;110(1):113-9.

Lockwood BC, North MJ, Scott KI, Bremner AF, Coombs GH. The use of a highly sensitive electrophoretic method to compare the proteinases of trichomonads. Mol Biochem Parasitol. 1987;24(1):89-95.

Arroyo R, Engbring J, Alderete JF. Molecular basis of host epithelial cell recognition by Trichomonas vaginalis. Mol Microbiol 1992; 6(7): 853-62.

Garber G E , Lemchuk-Favel L T. Characterization and purification of extracellular proteases of Trichomonas vaginalis. Can J Microbiol. 1989;35(10):903-9.

Garber GE, Lemchuk-Favel LT. Analysis of the extracellular proteases of Trichomonas vaginalis. Parasitol Res. 1994;80(5):361-5.

Neale KA, Alderete JF. Analysis of the proteinases of representative Trichomonas vaginalis isolates. Infect Immun. 1990;58(1):157-62.

Provenzano D, Alderete JF. Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis. Infect Immun. 1995;63(9):3388-95.

Irvine JW, North MJ, Coombs GH. Use of inhibitors to identify essential cysteine proteinases of Trichomonas vaginalis. FEMS Microbiol Lett. 1997;149(1):45-50.

Cardenas-Guerra RE, Arroyo R, Rosa de Andrade I, Benchimol M, Ortega-Lopez J. The iron-induced cysteine proteinase TvCP4 plays a key role in Trichomonas vaginalis haemolysis. Microbes Infect. 2013;15(13):958-68.

Twu O, Dessi D, Vu A, Mercer F, Stevens G C, de Miguel N, et al. Trichomonas vaginalis homolog of macrophage migration inhibitory factor induces prostate cell growth, invasiveness, and inflammatory responses. Proc Natl Acad Sci U S A. 2014;111(22):8179-84.

Ackers JP, Lumsden WH, Catterall RD, Coyle R. Antitrichomonal antibody in the vaginal secretions of women infected with T. vaginalis. Br J Vener Dis. 1975;51(5):319-23.

Su KE. Antibody to Trichomonas vaginalis in human cervicovaginal secretions. Infect Immun. 1982;37(3):852-7.

Garber GE, Lemchuk-Favel LT. Association of production of cell-detaching factor with the clinical presentation of Trichomonas vaginalis. J Clin Microbiol. 1990;28(11):2415-7.

Hogue MJ. The Effect of Trichomonas Vaginalis on Tissue–Culture Cells. American Journal of Epidemiology 1943;37(2):142-52.

Pindak FF, Gardner WA, Mora de Pindak M. Growth and cytopathogenicity of Trichomonas vaginalis in tissue cultures. J Clin Microbiol. 1986;23(4):672-8.

Draper D, Donohoe W, Mortimer L, Heine RP. Cysteine proteases of Trichomonas vaginalis degrade secretory leukocyte protease inhibitor. J Infect Dis. 1998;178(3):815-9.

Draper L, Landers DV, Krohn MA, Hillier SL, Wiesenfeld HC, Heine RP. Levels of vaginal secretory leukocyte protease inhibitor are decreased in women with lower reproductive tract infections. Am J Obstet Gynecol. 2000;183(5):1243-8.

McGrory T, Garber GE. Mouse intravaginal infection with Trichomonas vaginalis and role of Lactobacillus acidophilus in sustaining infection. Infect Immun. 1992;60(6):2375-9.

McGrory T, Meysick K, Lemchuk-Favel LT, Garber GE. The interaction of Lactobacillus acidophilus and Trichomonas vaginalis in vitro. J Parasitol. 1994;80(1):50-4.

Phukan N, Parsamand T, Brooks AE, Nguyen TN, Simoes-Barbosa A. The adherence of Trichomonas vaginalis to host ectocervical cells is influenced by lactobacilli. Sex Transm Infect. 2013;89(6):455-9.

Gillin FD, Sher A. Activation of the alternative complement pathway by Trichomonas vaginalis. Infect Immun. 1981;34(1):268-73.

Alderete JF, Provenzano D, Lehker MW. Iron mediates Trichomonas vaginalis resistance to complement lysis. Microb Pathog. 1995;19(2):93-103.

Demes P, Gombosova A, Valent M, Janoska A, Fabusova H, Petrenko M. Differential susceptibility of fresh Trichomonas vaginalis isolates to complement in menstrual blood and cervical mucus. Genitourin Med. 1988;64(3):176-9.

Coombs GH, Westrop GD, Suchan P, Puzova G, Hirt RP, Embley TM, et al. The amitochondriate eukaryote Trichomonas vaginalis contains a divergent thioredoxin-linked peroxiredoxin antioxidant system. J Biol Chem. 2004;279(7):5249-56.

Khoshnan A, Alderete JF. Trichomonas vaginalis with a double-stranded RNA virus has upregulated levels of phenotypically variable immunogen mRNA. J Virol. 1994;68(6):4035-8.

North MJ, Robertson CD, Coombs GH. The specificity of trichomonad cysteine proteinases analysed using fluorogenic substrates and specific inhibitors. Mol Biochem Parasitol. 1990;39(2):183-93.

Krieger JN, Verdon M, Siegel N, Holmes KK. Natural history of urogenital trichomoniasis in men. J Urol. 1993;149(6):1455-8.

Kurth A, Whittington W L, Golden M R, Thomas K K, Holmes K K, Schwebke J R. Performance of a new, rapid assay for detection of Trichomonas vaginalis. J Clin Microbiol. 2004;42(7):2940-3.

Sviben M, Missoni EM, Mestrovic T, Vojnovic G, Galinovic G M. Epidemiology and laboratory characteristics of Trichomonas vaginalis infection in Croatian men with and without urethritis syndrome: a case-control study. Sex Transm Infect. 2015.

Joyner JL, Douglas JM, Ragsdale S, Foster M, Judson FN. Comparative prevalence of infection with Trichomonas vaginalis among men attending a sexually transmitted diseases clinic. Sex Transm Dis. 2000;27(4):236-40.

Schwebke JR , Hook EW, 3rd. High rates of Trichomonas vaginalis among men attending a sexually transmitted diseases clinic: implications for screening and urethritis management. J Infect Dis. 2003;188(3):465-8.

Ng A, Ross JD. Trichomonas vaginalis infection: How significant is it in men presenting with recurrent or persistent symptoms of urethritis? Int J STD AIDS. 2015.

Seo MY, Im S J, Gu NY, Kim JH, Chung YH, Ahn MH, et al. Inflammatory response of prostate epithelial cells to stimulation by Trichomonas vaginalis. Prostate. 2014;74(4):441-9.




DOI: https://doi.org/10.22037/nbm.v3i3.8288