Acute Motor Axonal Neuropathy (Aman) With Motor Conduction Blocks In Childhood; Case Report
Iranian Journal of Child Neurology,
Vol. 10 No. 1 (2016),
1 January 2016
,
Page 70-72
https://doi.org/10.22037/ijcn.v10i1.6973
Abstract
How to Cite This Article: Yıldırım S. Inan AR, Gül LH, Türk Börü Ü. An Acute Motor Axonal Neuropathy (AMAN) Case With Motor Conductıon Blocks In Childhood. Iran J Child Neurol. Winter 2016; 10(1):65-69.
Abstract
Objective
characterized with decreased compound muscle action potentials (CMAP) and absence of demyelinating findings in electrophysiological studies, is a subtype of Guillain-Barre Syndrome (GBS). A 4 yr-old male patient presented with ascending weakness, dysarthria and dysphagia to İstanbul Dr. Lütfi Kırdar Kartal Training and Research Hospital Neurology outpatient for three days to in 2012. Dysphonia, restricted eye movements, flaccid tetraplegia and areflexia were found in neurological examination. There were motor conduction blocks in all peripheral nerves in electrophysiological studies.According to these findings the patient was diagnosed as Acute Inflammatory Demyelinating Polyradiculoneuropathy (AIDP). Reduction of CMAP amplitudes in posterior tibial nerve, absence of CMAPs in median, ulnar and peroneal nerves and loss of motor conduction blocks were found in following electrophysiological studies. According to these findings, patient was diagnosed as AMAN. Motor conduction blocks may appear in early stage of AMAN and they disappear in later examinations.
That’s why electrophysiological studies must be repeated in patients with GBS.
- Acute motor axonal neuropathy
- Motor conduction blocks
- Guillain-Barre Syndrome
How to Cite
References
Uncini A, Manzoli C, Notturno F, Capasso M. Pitfalls in electrodiagnosis of Guillain-Barre´syndrome subtypes. J Neurol Neurosurg Psychiatry 2010;81(10):1157-1163.
Hadden RDM, Cornblath DR, Hughes ARC, Zielasek J, Hartung HP, Toyka KV et al. Electrophysiological classification of Guillain-Barre´ syndrome: clinical associations and outcome. Ann Neurol 1998;44(5):780-788.
Capasso M, Caporale CM, Pomilio F, Gandolfi P, Lugaresi A, Uncini A. Acute motor conduction block neuropathy. Another Guillain–Barre´ syndrome variant. Neurology 2003;61(5):617–622.
Kannan MA,Ch RK,Jabeen SA,Mridula KR,Rao P,Borgohain R.Clinical, electrophysiological subtypes and antiganglioside antibodies in childhood Guillain- Barré syndrome. Neurology India 2011;59(5):727-732.
Korinthenberg R,Schessl J,Kirschner J. Clinical Presentation and Course of Childhood Guillain-Barré Syndrome: A Prospective Multicentre Study. Neuropediatrics 2007; 38(1):10-17.
Kokubun N, Nishibayashi M, Uncini A,Odaka M, Hirata K, Yuki N. Conduction block in acute motor axonal neuropathy. Brain 2010: 133(10); 2897–2908.
Yadegari S, Nafissi S, Kazemi N. Comparison of electrophysiological findings in axonal and demyelinating Guillain-Barre Syndrome. Iran J Neurol 2014;13(3):138-143.
Kuwabara S, Mori M, Ogawara K, Mizobuchi K, Hattori T, Koga M, et al. Axonal involvement at the common entrapment sites in Guillain-Barre´ syndrome with IgG anti-GM1 antibody. Muscle Nerve 1999; 22(7): 840–845.
Takigawa T, Yasuda H, Kikkawa R, Shigeta Y, Saida T, Kitasato H. Antibodies against GM1 ganglioside affect K+ and Na+ currents in isolated rat myelinated nerve fibers. Ann Neurol 1995; 37(4): 436–442.
Susuki K, Rasband MN, Tohyama K, Koibuchi K, Okamoto S, Funakoshi K et al. Anti-GM1 antibodies cause complement-mediated disruption of sodium channel clusters in peripheral motor nerve fibers. J Neurosci 2007; 27(15): 3956–3967.
Griffin JW, Li CY, Macko C, Ho TW, Hsieh ST, Xue P, et al. Early nodal changes in the acute motor axonal neuropathy pattern of the Guillain-Barre´ syndrome. J Neurocytol 1996; 25(1): 33–51.
Manganelli F, Pisciotta C, Iodice R, Calandro S, Dubbioso R, Ranieri A, et al. Case of acute motor conduction block neuropathy (AMCBN). Muscle Nerve 2009; 39(2): 224– 226.
Cheng BC, Chang WN, Chang CS, Chee CY, Huang CR, Chen JB, et al. Guillain-Barré syndrome in southern Taiwan: Clinical features, prognostic factors and therapeutic outcomes.Eur J Neurol2003;10(6):655–662.
Chio A, Cocito D, Leone M, Giordana MT, Mora G, Mutani Ret al. Register for Guillain-Barre Syndrome. Guillain-Barre syndrome: A prospective, population-based incidence and outcome survey. Neurology2003;60(7):1146–1150.
Delanoe C, Sebire G, Landrieu P, Huault G, Metral S. Acute inflammatory demyelinating polyradiculopathy in children: Clinical and electrodiagnostic studies.Ann Neurol1998;44(3):350–356.
Lee JH, Sung IY, Rew IS. Clinical presentation and prognosis of childhood Guillain-Barré syndrome. J Paediatr Child Health.2008;44(7-8):449–454.
- Abstract Viewed: 397 times