Relationship between Iron Deficiency Anemia and Febrile Seizures

Susan AMIRSALARI--- MD,Pediatric Neurologist, Assistant Professor, Baqyiatallah University Medical Sciences, Tehran, Iran,
Zarrin Taj KEIHANI DOUST--- MD,Pediatric Neurologist, Associate Professor, Tehran University of Medical Sciences, Tehran, Iran,
Mostafa AHMADI--- Medical students, Baqyiatallah University of Medical Sciences,Tehran, Iran,
Amin SABOURI--- Medical students, Baqyiatallah University of Medical Sciences,Tehran, Iran,
Zohreh KAVEMANESH--- MD,Associate Professor, Baqyiatallah University of Medical Sciences, Tehran, Iran,
Shahla AFSHARPEYMAN--- MD,Assistant Professor, Baqyiatallah University of Medical Sciences, Tehran, Iran,
Mohammad TORKAMAN--- MD,Assistant Professor, Baqyiatallah University of Medical Sciences, Tehran, Iran,
Yasaman GHAZAVI--- Medical student, Shahid Beheshti University of Medical Sciences, Tehran,Iran

Abstract


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Objective

Febrile seizure is the most common convulsive disorder in childhood. The role of iron in metabolism of neurotransmitters and carrying oxygen to the brain suggests the possibility of a relationship between iron deficiency anemia and febrile seizures.

The aim of this study was to investigate the relationship between iron deficiency anemia and febrile seizures.

Materials & Methods

This case - control study was performed on 132 cases and 88 controls, aged 9 months to 5 years, from July 2007 to June 2009 in Baqyiatallah Hospital. Patients were selected using simple random sampling. The case group included children with first febrile seizure (core temperature over 38.5˚C during  seizure) without a central nervous system infection or an acute brain insult. The control group included children suffering from a febrile illness without seizure. Iron deficiency anemia was defined with one of these laboratory indexes: 1) Hemoglobin (Hb) <10.5mg/dl 2) Plasma ferritin <12ng/dl 3) Mean corpuscular volume (MCV) <70  fl. The data collected from patients were analyzed with SPSS.13 software.

Results

Low plasma ferritin was found in 35 cases (26.5%) compared to 26 controls (29.5%), low Hb level was found in 4 cases (3%) compared to 6 controls (6.8%) and low MCV was found in 5 cases (3.8%) compared to 6 controls (6.8%).

There was no significant difference in plasma ferritin , Hb level and MCV indices between the two group.

Conclusion

Considering the above-mentioned results, there is no relationship between iron deficiency anemia and febrile seizures.


Keywords


Iron deficiency anemia, febrile seizures, Children

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