Granzyme H Serum Levels Variations with Both Reproductive Hormone receptors, and Related Hormone Receptors in Breast Cancer Patients

Behnoosh Tahbaz lahafi--- Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Mohammad-Esmaeil Akbari--- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Houshang Amir-rassouli--- Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Ali Rahimipour--- Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Eznollah Azargashb--- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Nahid Nafissi--- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Farida Jahani--- Cancer Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Abstract


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Background: Breast Cancer (BC) is the most common cancer in Iranian women, meanwhile the Iranian patients are relatively young. Granzyme H (GZMH) is a functional cytotoxic serine protease of NK cell granules, which expands the cell death-inducing repertoire of innate immune system. GZMH is constitutively and highly expressed in human NK cells, in order to possess chymotrypsin-like (chymase) enzymatic activity. The purpose of this study was to determine GZMH level, in BC and healthy women.

Methods: 30  breast  cancer  patients , and 30 control  women  in  premenopausal  status, have participated in  this  study. GZMH , Estrogen levels, and ER,PR have been measured in cancer and healthy women subsequently, as using ELISA , Radioimmunoassay, and  Immunohistochemistry methods.

Results: Mean GZMH value was lower in BC than healthy women (p<0.0001).

Conclusions: our study has implicated suppressor existence, or the problem for producing of GZMH in patients group, and levels of estrogen that could not effect on making positive ER, PR.

Keywords: Breast Cancer; Estrogen; Granzyme H

 

Please cite this article as: Tahbaz-lahafi B, Akbari ME, Amir-rassouli H, Rahimipour A, Azargashb E, Nafissi N, Jahani F. Granzyme H Serum Levels Variations with Both Reproductive Hormone receptors, and Related Hormone Receptors in Breast Cancer Patients. Iran J Cancer Prev. 2014; 7(1):48-52.


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Keywords


Breast Cancer; Estrogen; Granzyme H

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