Five and Ten Years Survival in Breast Cancer Patients Mastectomies vs. Breast Conserving Surgeries Personal Experience

Mohammad Esmaeil Akbari--- Professor of Surgical oncology, Cancer Research Center, Shahid Beheshti University (MC),
Maryam Khayamzadeh--- Community Medicine Specialist, Cancer Research Center, Shahid Beheshti University (MC),
SJ Khoshnevis--- Surgeon, Cancer Research Center, Shahid Beheshti University (MC),
Nahid Nafisi--- Surgeon, Cancer Research Center, Shahid Beheshti University (MC),
A Akbari--- MD, Cancer Research Center, Shahid Beheshti University (MC)

Abstract


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Abstract:
Background: Breast Carcinoma is the first malignancy among Iranian ladies and the second cause of death due to cancers after gastric carcinoma. According to the World Health Organization the annual incidence rate of breast cancer will rise 1.8 to 2 percent. It is one of the most important health problems. Five year survival is one of the indicators used for evaluation of the quality of care to different types of malignancies. In this study we decided to compare the result of mastectomy and breast conserving surgery in the survival of patients with breast carcinoma..
Material and Method: This is a retrospective study using data from breast carcinoma cases in a private clinic under supervision of the author during years 1994 until 2007. These cases base on the clinical status underwent surgery as mastectomy or breast conserving with other necessary treatment. The number of patients with acceptable follow up was 464 cases that 441 were included to define survival. The data were analyzed by SPSS and survival estimated by Kaplan Mayer method.
Results: Survival curve was estimated for 441 cases of them, six cases were men and the age of patients was 22 to 104 years old with average of 53.24 years and standard deviation of 12.41. The most cases were among 45-55 years old. Five and ten years survival for all cases was 81 % and 77% respectively. These data for mastectomies patients was 78 and 70 percent and for breast preserving cases was 86 and 78 percent which was not significant in log rank test with p-value equally 0.13. There was no significant difference between mastectomies patients versus breast preserving cases in all clinical stages although the crude data shows better situation in breast preserving surgery (BPS).
Discussion: Breast cancer is one of the most important health problems, nowadays breast preserving surgery is choice treatment for stage I and II throughout the world. In this study overall 5 years survival was 81% comparable with developed countries with different health delivery system and quality of care and it is much better than other reports from Iran, regional and comparable countries. Because of many reasons such as physical, social and psychological effect of BPS, we recommend it as the best choice for managing breast cancer patients in stage I and II and even III in clinically approved cases in Iran similar to other countries.

Keywords: breast cancer, survival,mastectomy

Please cite this article as: Akbari ME,Khayamzade M, Khoshnevis SJ, Nafisi N,Akbari A. Five and Ten Years Survival in Breast Cancer Patients Mastectomies vs. Breast Conserving Surgeries Personal Experience. Iran J Cancer Prev. 2008; 1(2): 53-56.

References:

1. Ministry of Health &Medical Education, Health deputy,

Iranian annual of national cancer registration report, 2005-

2006, Iran

2. Naghavi M. Iranian annual of national death

registration report. Ministry of Health &Medical

Education,2005

3. Ministry of Health &Medical Education, Health deputy.

National Burden of Disease & Injury in I.R.IRAN. 2006

4. Swanson GP, Rynearson K, Geyer CE JR. Breast

conservation in the treatment of breast cancer,Community-

Based experience, South Med J. 2001;94(3):287-92

5. Albain KS,Allred DC,Clark GM. Breast cancer outcame

and predictors of outcame.Are there age

differentials?Monograph of National Cancer Institute,

1994;6:35-42

6. Walker RA, Lees E, Webb MB. Breast carcinomas

occurring in young women are different. British Journal of

Cancer. 1996;74:1796-1800

7. Kroman N, Jense MB, Wohlfahrt J,Mouridsen

HT,Anderson PK. Factors influencing the effect of age on

prognosis in breast cancer,Population-based study. British

Medical Journal. 1998;320:447-9

8. Giordano SH, Buzdar AU, Smith TL, Kau SW, Yang Y,

Hortobagyi GN. Is breast cancer survival improving?,

Cancer. 2004 Jan 1;100(1):44-52.

9. Rajaeifard A, Talei A,Baneshi M. Survival analysis models

for breast cancer patiets in Shiraz,1993-

2002;JMR,3(4):41-50

10. Vahdaninia M, Harirchi MR,Montazeri A,5 years

survival in breast cancer in Imam Khomeini hospital.A

prospective study. Payesh.1382;2(2):141-8

11. Charles Brunicardi F, Anderson DK, Timothy R. Shartzs

principle of surgery. Mc Grow-Hill professional. 2004

12. The result of the last census in I.R.IRAN

13. Landis SH, Murray T, Bolden SH, Wingo PhA. Cancer

Statistics. Cancer.1998; 48:6-30

14. Jin f. Xiang YB. Gao YT. Cancer survival in

Shanghai.Peoples republic of China. IARC Sci

Pub.1998(145):37-50

15. Nomura K, Sobue T, Nakatani H, Maehara H, Cancer

statistics in Japan 2005.Tokyo-Japan foundation for

promotion cancer research. 2005

16. Sankaranarayanan R, Swaminathan R, Brenner H.

Cancer survival in developing countries. An overview

17. Jin-Hee Lee, Seon-Hee Yim, Young Joo Won, Kyu Won

Jung, Population –based breast cancer statistics in Korea

during 1993-2002. Incidence,Mortality & survival,J Korean

Med sci. 2007;22(Supp)S11-6

18. Martin N, Srisukho S, Kunpradist O, Suttajit MCancer

survival in Chiang Mai, Thailand, IARC Sci Publ.

1998;(145):109-21

19. Shanta V, Gajalakshmi CK, Swaminathan R. Cancer

survival in Chennai (Madras). India, IARC Sci Publ.

1998;(145):89-100

20. Gajalakshmi CK, Shanta V, Swaminathan R,

Sankaranarayanan R. Black RJ A population-based survival

study on female breast cancer in Madras, India.Br J Cancer.1997;75(5):771-5.


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