A Survey on Zinc Status among Chronic Allergic Asthma and in Atopic Phenotype
International Journal of Medical Toxicology and Forensic Medicine,
Vol. 5 No. 1(Winter) (2015),
30 March 2015
,
Page 1-7
https://doi.org/10.22037/ijmtfm.v5i1(Winter).5817
Abstract
Background: Incidence of allergic asthma has increased in the worldwide. Zinc has significant effects on the pathogenesis of bronchial asthma. However, Zinc deficiency caused the enhanced allergy state. Investigations on the recent issue have been less often considered, and only a few studies were found in the literature review. Zinc status particularly has not been known in adult's allergic asthma. The aim of the study was to assess the sera level of zinc in chronic allergic asthma patient with atopic phenotype.
Methods: A total 48 chronic allergic asthma phenotype enrolled among asthmatic population based on the protocol. Skin prick test was applied with six standard extract allergens. Total Immunoglobulin E antibodies and zinc level were measured in sera with the recommendation manufacturer.
Results: The mean age was 32.75±9.86 SD years. Gender distribution was 52% females and 48% males. Mean of total IgE and zinc levels in sera was higher in males than females. 27% of participants had hypozincemia. Hypozincemia subset had a higher mean of total IgE level than a normal zinc level subset. Atopic phenotype was detected in 21% target population. Atopic asthmatic phenotype disclosed hypozincemia status with frequency 23%. Marked differences were observed between zinc and total IgE levels (p=0.04).
Conclusion: The outcome disclosed there was a hypozincemia in the target population and atopic phenotype subset. Hypozincemic allergic asthmatic patients had a higher mean of total IgE level than normal Zinc level subjects. Allergic marker and hypozincemia were marked in the male and female focus population, respectively.
- Asthma
- Allergy
- Atopic phenotype
- Zinc deficiency
- Adults
How to Cite
References
Zalewski PD, Truong-Tran AQ, Grosser D, Jayaram L, Murgia C, Ruffin RE. Zinc metabolism in airway epithelium and airway inflammation: basic mechanism and clinical targets. A review. Pharmacology & Therapeutics. 2005;105(2):127–49.
Prasad A, Bao B, Beck FWJ, Kuck O, Sakar F. Antioxidant effect of zinc in humans. Free Radic Bio Med. 2004;37:1182-92.
Zalewski PD. Zinc metabolism in the airway: basic mechanisms and drug targets. 2006;6(3):237-43.
Shankar AH, Prasad AS. Zinc and immune function: the biological basis of altred resistance to infection. Am J Clin Nutr. 1998; 68(2 Suppl):447S-463S.
Goldey DH, Mansmann HC, Rasmussen AI. Zinc status of asthmatic, prednisone-treated asthmatic and non-asthmatic children. J Am Diet Assoc. 1984;84(2):157-63.
Sinha SN, Gabrieli ER. Serum copper and zinc levels in various pathologic conditions. Am J Clin Pathol. 1970;54:570-7.
Ghasemi A, Zahediasl S, Hosseini-Esfahani F, Azizi F. Reference values for serum zinc concentration and prevalence of zinc deficiency in adult Iranian subjects. Biol Trace Elem Res. 2012;149(3):307-14.
Agin Kh, Tehrani Mm. Status of trace elements of zinc, magnesium,calcium electrolyte in serum among stable chronic persistent asthma in Tehran. Forensic Medicine and Toxicology 2012;2(1):6-12.
O'Driscoll BR, Hopkinson LC. Denning DW. Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med. 2005;18;5(4):61-9.
Umetsu DT, Dekruyff HR. The regulation of allergy and asthma. Immunologic review 2006;212:238-55.
Sprietsma E. Zinc-controlled Th1/Th2 switch significantly determines development of diseases. Medical Hypothesis. 1997;49(1):1-14.
Kamer B, Wąsowicz W, Pyziak K, Kamer-Bartosińska A, Gromadzińska J, Pasowska R. Role of selenium and zinc in the pathogenesis of food allergy in infants and young children. Arch Med Sci. 2012;8(6):1083-8.
David TJ, Waddington E, Stanton RHJ. Nutritional hazards of elimination diets in children with atopic eczema. Arch Dis Child. 1984;59(4):323-5.
Expert Panel Report 3: Guidelines for the Diagnosis and Management of Asthma. Available at:
http://www.nhlbi.nih.gov/guidelines/asthma/asthgdln.pdf. Accessed: 2013 year.
Dreborg S. The safety of Skin tests and the information obtained from using different methods and concentrations of allergen. Allergy.1993;48(7):473–5.
Position paper: Allergen standardization and skin tests. The European Academy of Allergology and Clinical Immunology. 1993;48 (suppl.14):48–821.
Baldacci S, Omenaas E, Oryszczyn MP. Allergy markers in respiratory epidemiology. Eur Respir J. 2001;17(4):773-90.
Halsted JA, Ronaghy HA, Abadi P, Haghshenass M, Amirhakemi GH, Barakat RM, Reinhold JG. Zinc deficiency in man, The Shiraz experiment. Am J Med. 1972;53(3):277-84.
Reinhold JG. High phytate content of rural Iranian bread: a possible cause of human zincdeficiency. Am J Clin Nutr. 1971;24(10):1204-6.
Dabbaghmanesh MH, Taheri Boshrooyeh H, Kalantarhormozi MR, Ranjbar Omrani GH. Assessment of zinc concentration in random samples of the adult population in Shiraz, Iran. Iran Red Crescent Med J. 2011;13(4):249-55.
Truong-Tran AQ, Carter J, Ruffin R, Zalewski PD. New insights into the role of zinc in the respiratory epithelium. Immunol Cell Biol. 2001;79(2):170-7.
Soutar A, Seaton A, Brown K. Bronchial reactivity and dietary antioxidants. Thorax. 1997;52(2):166-70.
Tudor R, Zalewski PD, Ratnaike RN. Zinc in health and chronic disease. J Nutr Health Aging. 2005;9(1):45-51.
Devirgiliis C, Zalewski PD, Perozzi G, Murgia C. Zinc fluxes and zinc transporter genes in chronic diseases. Mutat Res. 2007;622(1-2):84-93.
Zalewski PD. Zinc metabolism in the airway: basic mechanisms and drug targets. Curr Opin Pharmacol. 2006;6(3):237-43.
Flynn A, Pories W, Strain WH, Hill OA, Fratianne RB. Rapid serum zinc depletion associated with corticosteroid. Lancet; 1971;2(7735):1169–71.
Ellul-Micallef R, Galdes A, Fenech FF. Serum zinc levels in corticosteroid-treated asthmatic patients. Postgrad Med J. 1976;52(605):148–1.
Goldey DH, Mansmann H, Rasmussen AI. Zinc status of asthmatic, prednisone-treated asthmatic, and non-asthmatic children. J Am Diet Assoc. 1984;84(2):157-63.
Flynn A, Pories JW, Strain Wh. Zinc deficieny with altered adrenocortcal function and its relation to delayed healing. Lancet. 1973;1(7807):789-90.
Hood S. The role of diet in asthma development. Respir Care. 2001;6:8-9.
Lang C, Murgia C, Leong M, Tan LW, Perozzi G, Knight D, Ruffin R, Zalewski P. Anti-inflammatory effects of zinc and alterations in zinc transporter mRNA in mouse models of allergic inflammation. Am J Physiol Lung Cell Mol Physiol. 2007;292(2): 577-84.
Georas SN, Guo J, De Fanis U, Casolaro V. T-helper cell type-2 regulation in allergic disease. Eur Respir J. 2005;26(6):1119-37.
- Abstract Viewed: 452 times
- PDF Downloaded: 336 times