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Research Paper: Quantification of Mortality Rate From Illicit Substance Abuse in Iran in 2016

Abdolrazagh Barzegar, Fatemeh Shahbazi, Davood Mirtorabi, Mohammad Reza Ghadirzadeh, Ahmad Shojaei, Seyed Saeed Hashemi Nazari




Background: The present study aimed to evaluate the epidemiology of mortality due to substance abuse to provide useful information for local, national, and international administrators.
Methods: This cross-sectional study was carried out in 12 months from March 2016 to February 2017. The study population was a random sample of people who died from substance abuse. Data were collected by checklists which were designed according to the study objectives. The obtained data were analyzed in Stata software.
Results: Our findings show that the mortality rate for illicit opiate users was 40.90 per 1000000 population. Most deaths occurred among people aged 30 to 39 years (25%), single (46.75%) with low education levels. Kermanshah, Lorestan, and Alborz provinces had the highest mortality rate. History of overdose, suicide, hospitalization in psychiatric in hospital and incarceration was observed in some people who died from substance abuse.
Conclusion: A large number of deaths from drug abuse occurred in unmarried, self-employed, young males 30 to 39 years old with low education levels. We suggest that training programs and harm reduction approaches be focused in these high risk groups.


Opium, Opioids, Opioid dependence, Mortality, Epidemiology


Degenhardt L, Bucello C, Mathers B, Briegleb C, Ali H, Hickman M, McLaren J. Mortality among regular or dependent users of heroin and other opioids: a systematic review and meta‐analysis of cohort studies. Addiction. 2011 Jan 1; 106(1):32-51.

Green TC. Substance abuse, HIV infection, medication adherence, and mortality among a cohort of aging US veterans. Yale University; 2009.

Hayden A, Hayashi K, Dong H, Milloy MJ, Kerr T, Montaner JS, Wood E. The impact of drug use patterns on mortality among polysubstance users in a Canadian setting: a prospective cohort study. BMC public health. 2014 Dec; 14(1):1153.

Fischer B, Rehm J, Brissette S, Brochu S, Bruneau J, El-Guebaly N, Noël L, Tyndall M, Wild C, and Mun P, Baliunas D. Illicit opioid use in Canada: comparing social, health, and drug use characteristics of untreated users in five cities (OPICAN study). Journal of Urban Health. 2005 Jun 1; 82(2):250-66.

Day C, Nassirimanesh B, Shakeshaft A, Dolan K. Patterns of drug use among a sample of drug users and injecting drug users attending a General Practice in Iran. Harm reduction journal. 2006 Dec; 3(1):2.

Ghodse H, Oyefeso A, Kilpatrick B. Mortality of drug addicts in the United Kingdom 1967–1993. International Journal of Epidemiology. 1998 Jun 1; 27(3):473-8.

Poorolajal J, Haghtalab T, Farhadi M, Darvishi N. Substance use disorder and risk of suicidal ideation, suicide attempt and suicide death: a meta-analysis. Journal of Public Health. 2016 Sep 1; 38(3):e282-91.

Darvishi N, Farhadi M, Haghtalab T, Poorolajal J. Alcohol-related risk of suicidal ideation, suicide attempt, and completed suicide: a meta-analysis. PLoS One. 2015 May 20; 10(5):e0126870.

Furlan AD, Sandoval JA, Mailis-Gagnon A, Tunks E. Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects. Canadian Medical Association Journal. 2006 May 23; 174(11):1589-94.

Rosen CS, Kuhn E, Greenbaum MA, Drescher KD. Substance abuse–related mortality among middle-aged male VA psychiatric patients. Psychiatric Services. 2008 Mar; 59(3):290-6.

Coffin PO, Galea S, Ahern J, Leon AC, Vlahov D, Tardiff K. Opiates, cocaine and alcohol combinations in accidental drug overdose deaths in New York City, 1990–98. Addiction. 2003 Jun 1; 98(6):739-47.

Shokrzadeh M, Yazdani Charati J, Pourhossein M. epidemiological study of mortality rate from opioid abuse in referential bodies to Mazandaran Department of Forensic Medicine. Journal of Mazandaran University of Medical Sciences. 2014 Aug 15; 24(115):122-7.

Ghoreishi SM, Shahbazi F, Mirtorabi SD, Ghadirzadeh MR, Hashemi Nazari SS. Epidemiological study of mortality rate from alcohol and illicit drug abuse in Iran. Journal of research in health sciences. 2017 Oct 14; 17(4).

Razzaghi E, Rahimi A, Hosseini M, Chatterjee A. Rapid Situation Assessment (RSA) of drug abuse in Iran. Prevention Department, State Welfare Organization, Ministry of Health, IR of Iran and United Nations International Drug Control Program. 1999.

Powis B, Strang J, Griffiths P, Taylor C, Williamson S, Fountain J, Gossop M. Self‐reported overdose among injecting drug users in London: extent and nature of the problem. Addiction. 1999 Apr 1; 94(4):471-8.

HIV/AIDS and injecting drug abuse in the Islamic Republic of Iran. In: Best practice in HIV/AIDS prevention and care for injecting drug abusers. The Triangular Clinic in Kermanshah, Islamic Republic of Iran. (2004). Cairo, Egypt: World Health Organization, regional office for the Eastern Mediterranean. Retrieved November 26, 2006 from the World Wide Web: http://www.emro.who.int/asd/PDF/STD-052.pdf

Karbakhsh M, Zandi NS. Acute opiate overdose in Tehran: the forgotten role of opium. Addictive behaviors. 2007 Sep 1; 32(9):1835-42.

Day C, Nassirimanesh B, Shakeshaft A, Dolan K. Patterns of drug use among a sample of drug users and injecting drug users attending a General Practice in Iran. Harm reduction journal. 2006 Dec; 3(1):2.

Shahbazi F, Mirtorabi SD, Ghadirzadeh MR, Hashemi-Nazari SS, Barzegar A. Characterizing Mortality from Substance Abuse in Iran: An Epidemiological Study during March 2014 to February 2015. Addiction and Health. 2017 Nov 29; 9(3):166-74.

Dong K. Characterizing opioid overdose in Alberta [MSc thesis]. Alberta: University of Edmonton; 2007.

Fischer B, Brissette S, Brochu S, Bruneau J, El-Guebaly N, Noël L, Rehm J, Tyndall M, Wild C, Mun P, Haydon E. Determinants of overdose incidents among illicit opioid users in 5 Canadian cities. Canadian Medical Association Journal. 2004 Aug 3; 171(3):235-9.

Eslami-Shahrbabaki M, Fekrat A, Mazhari S. A study of the prevalence of psychiatric disorders in patients with methamphetamine-induced psychosis. Addiction & health. 2015; 7(1-2):37.

Dietze P, Cantwell K, Burgess S. Bystander resuscitation attempts at heroin overdose: does it improve outcomes? Drug & Alcohol Dependence. 2002 Jul 1; 67(2):213-8.

Brehm Christensen P, Hammerby E, Smith E, Bird SM. Mortality among Danish drug users released from prison. International Journal of Prisoner Health. 2006 Jan 1; 2(1):13-9.

Kardia SL, Rozek LS, Marks JL. Association of parental smoking history with nicotine dependence, smoking rate, and psychological cofactors in adult smokers. Addict Behav 2003; 28(8): 1447-52.

DOI: https://doi.org/10.22037/ijmtfm.v8i4(Autumn).22766