THE EFFECT OF NIGELLA SATIVA L. ON INTRACTABLE PEDIATRIC SEIZURES
Iranian Journal of Child Neurology,
Vol. 1 No. 1 (2006),
2 May 2009
,
Page 11-15
https://doi.org/10.22037/ijcn.v1i1.998
Abstract
Background:
Despite availability and administration of numerous antiepileptic drugs (AEDs) nearly 15% of childhood epilepsy cases are resistant to treatment; in traditional medicine however Nigella sativa L. (Black seed) has been known for its anticonvulsant effects.
Materials and Methods:
In this double-blind clinical trial conducted on children with refractory epilepsy we administered the aqueous extract of black seed as an adjunct therapy and compared the effects with those of a placebo. The study was performed between Sep 2003 and Nov 2004. The subjects received either extract or placebo for a period of four weeks and between these two periods for two weeks they received only their pre-existing anti-epileptic drugs (AEDs).
Results:
The mean frequency of seizures decreased significantly during treatment with extract, (p-value =0/007).
Conclusion:
It can be concluded that the water extract of Nigella sativa L. has antiepileptic effects in children with refractory seizures that do not respond to known AEDS.
keywords:
Nigella sativa, Intractable seizures, ChildrenHow to Cite
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