Early and Late Outcome of Premature Newborns with History of Neonatal Intensive Care Units Admission at 6 Years Old in Zanjan, Northwestern Iran




How to Cite This Article: Sadeghzadeh M, Khoshnevisasl P, Parvaneh M, Mousavinasab N. Early and Late outcome of Premature Newborns with history of NICU Admission at 6 years old in Zanjan, Iran. Iran J Child Neurol. Spring 2016; 10(2):67-73.


Premature birth is an important factor for mortality and morbidity of neonates. This study was designed to evaluate the outcome of preterm neonates who needed neonatal intensive care (NICU) hospitalization after 6 yr at their entrance to the school.

Materials & Methods

This cross sectional study was conducted on premature neonates consecutively hospitalized in NICU of Valie Asr Hospital (the Academic Pediatric Hospital, Zanjan, Northwestern Iran) from September 2001 to September 2003. All children with a history of prematurity and NICU treatment were evaluated at their entrance to the school. Demographic findings, clinical examinations, IQ test, hearing and visual acuity exams were recorded.


From 179 neonates, 78 (43.6%) survived and were discharged from hospital. Fifty-four of them were available and entered first grade in primary school. Only one case had severe mental retardation. One case had severe retinopathy of prematurity (ROP). Hearing abnormality was not detected in any case. There was no significant relation between IQ score, visual as well as hearing findings and gestational age.


We did not find significant disability in the outcome of surviving infants. This could be explained by the high mortality rate of neonates during hospitalization.



1. Fakher M, Shaaban W, Abdel Monein A, Hassan Z, Moustafa Fikry M. Statistical Study of Preterm Infants Admitted to NICU in Fawzy Moaz Hospital For Children. Alex J Pediatr 2005; 19 (1):155-8.
2. Fauth de Araújo B, Zatti H, Madi JM, Coelho MB, Olmi FB, Canabarro CT. Analysis of neonatal morbidity and mortality in late-preterm newborn infants. Jornal de Pediatria 2012 ; 88 (3): 259-266.
3. Stephens BE, Vohr BR. Neurodevelopmental outcome of the premature infant. Pediatr Clin North Am 2009; 56 (3):631-46.
4. Horbar JD, Carpenter JH, Badger GJ, Kenny MJ, Soll RF, Morrow KA, Buzas JS. Mortality and neonatal morbidity among infants 501 to 1500 grams from 2000 to 2009. Pediatrics 2012;129 (6): 1019-26.
5. Melamed N, Klinger G, Tenenbaum-Gavish K, Herscovici T, Linder N, Hod M, Yogev Y, Short-term Neonatal Outcome in Low-Risk, Spontaneous, Singleton, Late Preterm Deliveries. Obstetr Gynecol 2009 ; 114 ( 2): 253-260.
6. Larroque B, Ancel PY, Marret S, Marchand L, AndréM, Arnaud C, Pierrat V, RozéJC, Messer J, Thiriez G, Burguet A, Picaud JC, Bréart G, Kaminski M, EPIPAGE Study group. Neurodevelopmental disabilities and special care of 5-year-old children born before 33 weeks of gestation (the EPIPAGE study): a longitudinal cohort study. Lancet 2008; 371(9615): 813.
7. Sajedi F, Vameghi R, Mohseni Bandpei MA, Alizad V, Hemmati Gorgani S, Shahshahani Pour S. Motor developmental delay in 7500 iranian infants: prevalence and risk factors. Iran J Child Neurol 2009; 3(3):43-50.
8. Allen MC. Neurodevelopmental outcomes of preterm infants. Curr Opin Neurol 2008 ;21(2):123-8.
9. Beaino G, Khoshnood B, Kaminski M, Marret S, Pierrat V, Vieux R, Thiriez G, Matis J, Picaud JC, RozéJC, Alberge C, Larroque B, Bréart G, Ancel PY, EPIPAGE Study Group. Predictors of the risk of cognitive deficiency in very preterm infants: the EPIPAGE prospective cohort. Acta Paediatr 2011;100 (3): 370.
10. Mikkola K, Ritari N, Tommiska V, Salokorpi T,Lehtonen L, Tammela O, Pa¨a¨kko¨nen L, Olsen P, Korkman M, Fellman V, for the Finnish ELBW Cohort Study Group. Neurodevelopmental Outcome at 5 Years of Age of a National Cohort of Extremely Low Birth Weight Infants Who Were Born in 1996–1997. Pediatrics 2005;116:1391.
11. Mercier CE, Dunn MS, Ferrelli KR, Howard DB, Soll RF. Neurodevelopmental Outcome of Extremely Low Birth Weight Infants from the Vermont Oxford Network: 1998–2003. Neonatology 2010; 97: 329–338.
12. Neubauer AP, Voss W, Kattner E. Outcome of extremely low birth weight survivors at school age: the influence of perinatal parameters on neurodevelopment. Eur J Pediatr 2008; 167(1):87-95.
13. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics 2010;126(3):443-56.
14. Khan MR, Maheshwari pK, Shamim H, Ahmed S, Ali SR. Morbidity pattern of sick hospitalized preterm infants in Karachi, Pakistan. J Pak Med Assoc 2012; 62 (4): 386- 388.
15. Navaei F, Aliabady B, Moghtaderi J, Moghtaderi M, Kelishadi R. Early outcome of preterm infants with birth weight of 1500 g or less and gestational age of 30 weeks or less in Isfahan city, Iran. World J Pediatr 2010; 6 ( 3): 228-232.
16. Arafa MA, Alshehri MA, Predictors of neonatal mortality in the intensive care unit in Abha, Saudi Arabia. Saudi Med J 2003; 24 (12): 1374-1376.
17. Atalay D, Salihoğlu Ö, Can E, Beşkardeş A, Hatipoğlu S. Short-Term Outcomes of Very Low Birth Weight Infants Born at a Tertiary Care Hospital, Istanbul, Turkey. Iran J Pediatr 2013; 23(2): 205-211.
18. Mathews TJ, MacDorman MF. Infant Mortality Statistics From the 2007 Period Linked Birth/Infant Death Data Set. National Vital Statistics Reports. 2011;59(6).
19. Natarajan G, Shankaran S, Laptook AR, Pappas A, Bann CM, McDonald SA, et al. Apgar scores at 10 min and outcomes at 6-7 years following hypoxic-ischaemic encephalopathy. Arch Dis Child Fetal Neonatal Ed 2013 ;98(6):F473-9.
20. Tommiska V – Heinonenk Ikonen S – pokelu ML-Renlund M/Virtanen M-fellman V. A national short –term followup study of extremely LBW infants born in Finland in 1996-1997. Pediatrics 2001; 107 (1):1-9.
21. Ahmadpour M, Zahedpasha Y, Khafri S, Pishnamazi N. Short-term outcome of premature neonates admitted to NICU & newborn services at Amirkola children hospital in 2010. IJN 2012; 3( 3,4): 10.
22. Calisici E, Eras Z, Oncel MY, Oguz SS, Gokce IK, Dilmen U. Neurodevelopmental outcomes of premature infants with severe intraventricular hemorrhage. J Matern Fetal Neonatal Med 2014 ; 14:1-6.
23. Santos IS, Matijasevich A, Domingues MR, Barros AJD, Victora CG, Barros FC. Late preterm birth is a risk factor for growth faltering in early childhood: a cohort study; BMC Pediatrics 2009; 9:71.
24. Leversen KT, Sommerfelt K, Rønnestad A, Kaaresen PI, Farstad T, Skranes J, et al. Prediction of neurodevelopmental and sensory outcome at 5 years in Norwegian children born extremely preterm. Pediatrics 2011;127(3):e630.
25. Christian P, Murray-Kolb LE, Tielsch JM, Katz J, LeClerq SC, Khatry SK. Associations between preterm birth, small-for gestational age, and neonatal morbidity and cognitive function among school-age children in Nepal. BMC Pediatrics 2014;14:58.
26. Synnes AR, Anson S, Arkesteijn A, Butt A, Grunau RE, Rogers M, Whitfield MF. School entry age outcomes for infants with birth weight≤800 grams. J Pediatr. 2010;157(6):989.
27. van Baar AL, Vermaas J, Knots E, de Kleine MJ, Soons P. Functioning at school age of moderately preterm children born at 32 to 36 weeks’ gestational age. Pediatrics 2009; 124(1): 251.
28. Johnson S, Fawke J, Hennessy E, Rowell V, Thomas S, Wolke D, Marlow N. Neurodevelopmental disability through 11 years of age in children born before 26 weeks of gestation. Pediatrics 2009;124(2):e249.
29. Kerstjens JM, de Winter AF, Bocca-Tjeertes IF, ten Vergert EM, Reijneveld SA, Bos AF. Developmental delay in moderately preterm-born children at school entry. J Pediatr 2011; 159(1):92.
30. Soleimani F, Kazemnejad A,Vameghi R. Risk factor profiles of adverse neuromotor outcome in infants. Iran J Child Neurol 2010; 4 (4): 25-31.


Mortality; NICU; Outcome; Preterm infants; Prematurity

Full Text:



DOI: https://doi.org/10.22037/ijcn.v10i2.9032


  • There are currently no refbacks.

Copyright (c) Iranian Journal of Child Neurology