Human Herpes Virus Type 6 and Febrile Convulsion
Iranian Journal of Child Neurology,
Vol. 9 No. 4 (2015),
8 October 2015
How to Cite This Article: Houshmandi MM, Moayedi AR, Rahmati MB, Nazemi A, Fakhrai D, Zare Sh. Human Herpes Virus Type 6 and Febrile Convulsion. Iran J Child Neurol. Autumn 2015;9(4):10-14.
Febrile Convulsion (FC) is occurred in 6 months to 5 yr old children. The aim of this study was to investigate the prevalence of HHV-6 infection in FC admitted patients of Bandar Abbas Children Hospital, southern Iran.
Materials & Methods
In a cross-sectional study, 118 children aged 6-60 months who had FC were selected by a simple random method in 2010-11. Demographic data, clinical manifestation and two blood samples gathered to assess the human herpes virus type 6 (HHV6). Blood sample obtained at the time of admission and 10 days
after the first examination. ELISA was used to detect HHV-6 IgG. The subjects were studied in two groups with and without infection of HHV-6. Two groups were compared by t-test and X2.
Fifty-three subjects completed the study, including 30 boys (56.6 %) and 23 girls (43.4%). The HHV-6 infection was detected in 23 patients out of 53 studied subjects. The mean of age for the groups with and without HHV-6 infection was 19.7±9.7 and 20.4±10.2 months old, respectively. The most common clinical presentation in both groups was rhinorrhea, diarrhea, vomiting and lethargy without any significant difference between two groups. Five patients (21.7%) in HHV-6 group and 1 patient (3.3%) in HHV-6 negative group had postictal phase more than 15 minutes (P<0.05). Convulsion within 1 hour from beginning of fever was more frequent in HHV-6 infection group than the other group (P<0.01).
There was not any difference in terms of age group, gender and clinical manifestation of infected and non-infected children with FC. Postictal phase and seizure during 1 hour after the fever were significantly different between two groups.
- Febrile convulsion
Centers for disease control and prevention. Childhood Vaccines and febrile seizures. http://www.cdc.gov/
Millichap JG, Millichap JJ. Role of viral infections in the etiology of febrile seizures. Pediatr Neurol 2006; 35:165-72.
Hukin J, Farrell K, MacWilliam LM, Colbourne M, Waida E, Tan R, Morz L, Thomas E. Case-Control study of primary human herpesvirus 6 infection in children with febrile seizures. Pediatrics 1998; 101: 1-7.
Ansari A, Shaobing L, Abzug MJ, Weinberg A. Human herpes 6 and 7 and central nervous system infection in childhood. Emerg Infect Dis 2004; 10: 1450- 56.
Zerr DM, Meier AS, Selke SS, Frenkel LM, Huang ML, Wald A, Rhoads MP, Nguy L, Bornemann R, Morrow RA, Corey L. A population based study of primary human herpesvirus 6 infection. N Engl J Med 2005; 352(8): 768-76.
Laina I, Syriopoulou VP, Daikos GL, Roma ES, Papageorgiou F, Kakourout T, Theodoridou M. Febrile
seizures and primary human herpesvirus 6 infection. Pediatr Neurol 2010; 42: 28-31.
El Radhi AS, Carroll J, Klein N. Clinical manual of fever in children. Berlin: Springer; 2009: 2.
Mikati M. Febrile seizures. In: Kliegman RM, Stanton BF, Geme JW, Schor NF, Behrman RE, eds. Nelson textbook of pediatrics. 19 th ed. Philadelphia; Elsevier Saunders; 2011:2016- 2017.
Asano Y, Yoshikawa T, Suga S, Kobayashi I, Nakashima T, Yazaki T, Kajita Y, Ozaki T. Clinical features of infants with primary human herpesvirus 6 infection (exanthema subitum, roseola infantum). Pediatrics 1994; 93: 104-8.
Kwong KL, Lam SY, Que TL, Wong SN. Influenza A and febrile seizures in childhood. Pediatr Neurol 2006; 5:395-9.
Audenaert D, Van Broeckhoven C, De Jonghe P. Genes and loci involved in febrile seizures and related epilepsy syndromes. Hum Mutat 2006; 27:391-401.
Vianna RA, de Oliveira SA, Camacho LA, Knowles W, Brown D, Pereira AC, Velarde LG, Siqueira MM. Role of human herpesvirus 6 infection in young Brazilian children with rash illnesses. Pediatr Infect Dis J 2008; 27:533-7.
Kondo K, Nagafuji H, Hata A, Tomomori C, Yamanishi K. Association of human herpesvirus 6 infection of the central nervous system with recurrence of febrile convulsions. J Inf Dis 1993; 167: 1197-200.
Mannonen L, Herrgård E, Valmari P, Rautiainen P, Uotila K, Aine MR, Karttunen- Lewandowski P, Sankala J, Wallden T,Koskiniemi M. Primary human herpesvirus-6 infection in the central nervous system can cause severe disease. Pediatr Neurol 2007; 37:186-91
Suga S, Suzuki K, Ihira M, Yoshikawa T, Kajita Y, Ozaki T, Iida K, Saito Y, Asano. Clinical characteristics of febrile convulsions during primary HHV-6 infection. Arch Dis Child. 2000; 82: 62-66.
Hall CB, Long CE, Schnabel KC, et al. Human herpesvirus-6 infection in children. N Engl J Med 1994;
Jee SH, Long CE, Schnabel KC, Sehgal N, Epstein LG, Hall CB. Risk of recurrent seizures after a primary human herpesvirus 6- induced febrile seizure. Pediatr Infect Dis J 1998; 17:43-8.
Teach SJ, Wallace HL, Evans MJ, Duffneer PK, Hay J, Faden HS. Human herpesviruses types 6 and 7 and febrile seizures. Pediatr Neurol 1999; 21: 699-703.
Zerr DM, Frenkel LM, Huang ML, Rhoads M, Nguy L, Del Beccaro MA, Corey L. Polymerase chain reaction diagnosis of primary human herpesvirus-6infection in the cute care setting. J Pediatr 2006; 149:480-5.
Febrile Status Epilepticus linked to active HHV-6B and HHV-7 infection: Epileptic Seizures linked to Common Childhood Viral Infection. http://hhv-6foundation.org/ news/epileptic-seizures-linked-to-common-childhoodvirus-infection. June 2012.
- Abstract Viewed: 407 times
- PDF Downloaded: 226 times