The Etiology and Clinical Evaluations of Neonatal Seizures in Kashan, IRAN

Ahmad TALEBIAN, Mohammad JAHANGIRI, Mahin Rabiee RABIEE, Negin MASOUDI ALAVI, Hossein Akbari AKBARI, Zohreh SADAT

Abstract


286

How to Cite This Article: Talebian A, Jahangiri M, Rabiee M, Masoudi Alavi N, Akbari H, Sadat Z. The Etiology and Clinical Evaluations of
Neonatal Seizures in Kashan, IRAN. Iran J Child Neurol. Spring 2015;9(2):29-41.

 

Abstract

Objective

Detection of seizure, its etiology, and clinical types is important for guiding therapy. This study was designed to evaluate the etiology and clinical evaluations of neonatal seizures in Kashan, Iran.

Materials and Methods

The data of 100 hospitalized neonates with a complaint of seizures in Kashan City, from January 2006 to January 2011 were evaluated. The pediatric neurologist made the final diagnosis. The gestational age, neonate admission age, type of delivery, and laboratory and radiological investigations were reviewed   from the medical records. The relation of seizure etiology and other variables were compared using the Chi-square test. All the statistical analyses were performed using SPSS (ver 11.5).

Results

A total of 100 neonates were hospitalized with a diagnosis of seizures. The overall incidence rate of seizures was 2.6 per 1,000 live births. A total of 59% of seizures happened in the first three days of life. The etiologies of seizures were hypoxicischemic encephalopathy (HIE) (36%), hyponatremia (12%), hypoglycemia (11%), intracranial hemorrhage (11%), infections (10%), hypocalcemia (8%), metabolic disorders (7%), the structural anomalies (5%), and hypomagnesaemia (4%). In 23% of neonates, no specific etiology was found and 23% had multiple etiologies. In 45% of neonates, the EEG was not recorded. The type of the seizures were focal-clonic (26%), tonic (25%), multifocal clonic (34%), subtle

(11%), and myoclonic (4%). The types of the seizure were unrelated to the paraclinical findings.

Conclusion

Neonatal seizures are common and HIE was the main cause of seizures in this study. The clinical evaluation of neonatal seizures needs improvement.


Keywords


Etiology; Seizures; Neonate; KashanAbstract Objective Detection of seizure, its etiology, and clinical types is important for guiding therapy. This study was designed to evaluate the etiology and clinical evaluations of neonatal seizures in Kashan, Iran.

Full Text:

PDF

168

References


Mwaniki M, Mathenge A, Gwer S, Mturi N, Bauni E, Newton CR, et al. Neonatal seizures in a rural Kenyan District Hospital: aetiology, Incidence and outcome of hospitalization. BMC Med 2010; 8:16.

Vasudevan C, Levene M. Epidemiology and aetiology of neonatal seizures. Semin Fetal Neonatal Med 2013;18(4):185-91.

Pisani F, Piccolo B, Cantalupo G, Copioli C, Fusco C, Pelosi A, et al. Neonatal seizures and postneonatal epilepsy: a 7-y follow-up study. Pediatr Res 2012; 72(2):186-93.

Jensen FE. Developmental factors in the pathogenesis of neonatal seizures. J Pediatr Neurol 2009; 7(1):5-12.

Jensen FE. Neonatal Seizures: an update on mechanisms and management. Clin Perinatol 2009; 36(4): 881.

Spagnoli C, Pavlidis E, Pisani F. Neonatal seizures therapy: we are still looking for the efficacious drug. Ita J Pediatr 2013; 39:37.

Helmy MM, Ruusuvuori E, Watkins PV, Voipio J, Kanold P, Kaila K. Acid extrusion via blood–brain barrier causes brain alkalosis and seizures after neonatal asphyxia. Brain 2012; 135(Pt 11): 3311–9

Sadeghian A, Damghanian M, Shariati M. Neonatal seizures in a rural iranian district hospital: etiologies,

incidence and predicting Factors. Acta Medica Iranica 2012; 50(11): 760-764.

Chapman KE, Raol YH, Brooks-Kayal A. Neonatal seizures: controversies and challenges in translating new therapies from the lab to the isolette. Eur J Neurosci 2012; 35(12): 1857–1865.

Silverstein FS. Do seizures contribute to neonatal hypoxic-ischemic brain injury? J Pediatr 2009; 155(3):

–6.

Pisani F, Sisti L, Seri S. A scoring system for early prognostic assessment after neonatal seizures. Pediatrics 2009;124(4):e580-7

World Health Organization: Health status statistics: mortality. [http://www.who.int/ healthinfo/statistics/

indneonatalmortality/en/], Cited 30/04/09.

Gebremariam A, Gutema Y, Leuel A, Fekadu H. Early- onset neonatal seizures: types, risk factors and short-term outcome. Ann Trop Paediatr 2006; 26(2):127-131.

Loman AM, Ter Horst HJ, Lambrechtsen FA, Lunsing RJ. Neonatal seizures: aetiology by means of a standardized work-up. Eur J Paediatr Neurol 2014; 18(3):360-7.

Yıldız EP1, Tatlı B, Ekici B, Eraslan E, Aydınlı N, Calışkan M, Ozmen M.. Evaluation of etiologic and

prognostic factors in neonatal convulsion. Pediatr Neurol 2012; 47(3):186-92.

Moayedi AR, Zakeri S, Moayedi F. Neonatal seizure: etiology and type. Iran J Child Neurol 2008; 2(2): 23-26.

Okumura A. The diagnosis and treatment of neonatal seizures. Chang Gung Med J 2012; 35(5): 365-372.

Hallberg B, Blennow M. Investigations for neonatal seizures. Semin Fetal Neonatal Med 2013; 18(4):196-201.

Boylan GB, Stevenson NJ, Vanhatalo S. Monitoring neonatal seizures. Semin Fetal Neonatal Med 2013;

(4):202-8.

20. Van Rooij LG, Toet MC, Van Huffelen AC, Groenendaal F, Laan W, Zecic A, et al. Effect of treatment of subclinical neonatal seizures detected with a EEG: randomized, controlled trial. Pediatrics 2010; 125(2):e358-66.

Glass HC, Kan J, Bonifacio SL, Ferriero DM. Neonatal seizures: treatment practices among term and preterm. Pediatr Neurol 2012; 46(2): 111–5.




DOI: https://doi.org/10.22037/ijcn.v9i2.6248

Refbacks

  • There are currently no refbacks.


Copyright (c)