Melatonin’s Effect in Febrile Seizures and Epilepsy

Abolfazl MAHYAR--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.,
Parviz AYAZI--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.,
Reza DALIRANI--- 2. Department of Pediatric Nephrology, Mofid Children’s Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.,
Nargess GHOLAMI--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.,
Mohammad Mahdi DANESHI-KOHAN--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.,
Navid MOHAMMADI--- 3. Department of Community Medicine, Tehran University of Medical Sciences, Tehran, Iran.,
Mohammad Hossein AHMADI--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.,
Ahmad Ali SAHMANI--- 1. Department of Pediatrics, Qazvin University of Medical Sciences, Qazvin, Iran.

Abstract


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How to Cite This Article: Mahyar A, Ayazi P, Dalirani R, Gholami N, Daneshi-Kohan MM, Mohammadi N, Ahmadi MM, Sahmani AA. Melatonin’s Effect in Febrile Seizures and Epilepsy Iran J Child Neurol. 2014 Summer;8(3): 24-29.

 

Abstract
Objective
Recognition of risk factors for febrile seizures (FS) and epilepsy is essential. 
Studies regarding the role of melatonin in these convulsive disorders are limited.
This study determines the relationship between serum melatonin levels and FS and epilepsy in children.


Materials & Methods
A population of 111 children with simple FS, complex FS, and epilepsy (37 children per group, respectively) were included as case groups. In addition, 37 febrile children without seizures comprised the control group. Serum melatonin levels were measured and compared between all groups.


Results
The serum melatonin levels in the simple, complex FSs, and epilepsy groups were 2, 2.4, and 2 pg/ml, respectively. The serum melatonin level in the control group was 2.1pg/ml.
Moreover, there were no significant differences observed while comparing the case groups.


Conclusion
The present study reveals that there is no association between serum melatonin level and simple or complex FS and epilepsy. It appears that melatonin plays no significant role in these convulsive disorders.

 

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Keywords


Melatonin; Simple febrile seizures; Complex febrile seizures; Epilepsy

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DOI: http://dx.doi.org/10.22037/ijcn.v8i3.5590

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