Melatonin’s Effect in Febrile Seizures and Epilepsy

Abolfazl MAHYAR, Parviz AYAZI, Reza DALIRANI, Nargess GHOLAMI, Mohammad Mahdi DANESHI-KOHAN, Navid MOHAMMADI, Mohammad Hossein AHMADI, Ahmad Ali SAHMANI



How to Cite This Article: Mahyar A, Ayazi P, Dalirani R, Gholami N, Daneshi-Kohan MM, Mohammadi N, Ahmadi MM, Sahmani AA. Melatonin’s Effect in Febrile Seizures and Epilepsy Iran J Child Neurol. 2014 Summer;8(3): 24-29.


Recognition of risk factors for febrile seizures (FS) and epilepsy is essential. 
Studies regarding the role of melatonin in these convulsive disorders are limited.
This study determines the relationship between serum melatonin levels and FS and epilepsy in children.

Materials & Methods
A population of 111 children with simple FS, complex FS, and epilepsy (37 children per group, respectively) were included as case groups. In addition, 37 febrile children without seizures comprised the control group. Serum melatonin levels were measured and compared between all groups.

The serum melatonin levels in the simple, complex FSs, and epilepsy groups were 2, 2.4, and 2 pg/ml, respectively. The serum melatonin level in the control group was 2.1pg/ml.
Moreover, there were no significant differences observed while comparing the case groups.

The present study reveals that there is no association between serum melatonin level and simple or complex FS and epilepsy. It appears that melatonin plays no significant role in these convulsive disorders.



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Melatonin; Simple febrile seizures; Complex febrile seizures; Epilepsy

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