Evaluation of the quality of life in epileptic children of Shiraz, Southern Iran

Pegah Katibeh, Soroor Inaloo, Peyman Jafari, Fahimeh fattah, Samaneh Mazloomi



Introduction: People  suffer chronic disease like epilepsy are highly prone to debilitating changes in factors that affect the quality of life such as physical capacity, self-esteem, relationships with others and fulfillment of their daily life activities.  In this study, we decided to evaluate the quality of life in children with epilepsy in Shiraz, South Iran. Methods: Epileptic patients  referred to epilepsy clinic of Shiraz University of Medical Sciences and had no first time episode of seizures in the previous 6 months and no febrile-seizure were included in the study. Patients were evaluated using the standard KIDSCREEN-27 questionnaire. Data were analyzed using the statistical software SPSS 21, Man Whitney and Chi-square tests and reported in terms of descriptive statistics. The  significance level was considered less than 0.05. Results: In this case-control study, 229 children with epilepsy were compared with a control group of 400 normal individuals. The mean age  was 12.44±3.16 and 12.10±2.69 years. The tonic-clonic seizure had the highest prevalence . Being a boy, older age and having more seizures per year were associated with lower quality of life; in general, epileptic children had significantly lower QOL compared to normal cases. Conclusion: In general, epileptic children had an overall lower QOL while factors such as older age, male gender, and higher number of seizures over the years reduced the quality of life of these patients.  


epilepsy;quality of life; KIDSCREEN-27

Full Text:




Pitkänen A, Lukasiuk K. Molecular and cellular basis of epileptogenesis in symptomatic epilepsy. Epilepsy & behavior. 2009;14(1):16-25.

Organization WH. Epilepsy: Aetiology, epidemiology and prognosis (Fact sheet no. 165). Geneva: Author. 2001.

Mohammadi MR, Ghanizadeh A, Davidian H, Mohammadi M, Norouzian M. Prevalence of epilepsy and comorbidity of psychiatric disorders in Iran. Seizure. 2006;15(7):476-82.

Arnston P, Droge D, Norton R, Murray E. The perceived psychosocial consequences of having epilepsy. Psychopathology in epilepsy: social dimensions. 1986:143-61.

Hermann BP. Quality of life in epilepsy. Journal of epilepsy. 1992;5(3):153-65.

Antonak RF, Livneh H. Development, psychometric analysis, and validation of an error-choice test to measure attitudes toward persons with epilepsy. Rehabilitation Psychology. 1995;40(1):25.

Kurtzke JF. Epilepsy: Frequency, Causes and Consequences. Archives of Neurology. 1992;49(4):342-.

Elger CE, Helmstaedter C, Kurthen M. Chronic epilepsy and cognition. The Lancet Neurology. 2004;3(11):663-72.

Collings JA. Psychosocial Weil‐Being and Epilepsy: An Empirical Study. Epilepsia. 1990;31(4):418-26.

Jacoby A, Austin JK. Social stigma for adults and children with epilepsy. Epilepsia. 2007;48(s9):6-9.

McEwan M, Espie CA, Metcalfe J. A systematic review of the contribution of qualitative research to the study of quality of life in children and adolescents with epilepsy. Seizure. 2004;13(1):3-14.

Sidenvall R, Forsgren L, Heijbel J. Prevalence and characteristics of epilepsy in children in northern Sweden. Seizure. 1996;5(2):139-46.

Beilmann A, Napa A, Sööt A, Talvik I, Talvik T. Prevalence of childhood epilepsy in Estonia. Epilepsia. 1999;40(7):1011-9.

Larsson K, Eeg-Olofsson O. A population based study of epilepsy in children from a Swedish county. European Journal of Paediatric Neurology. 2006;10(3):107-13.

Austin JK, Smith MS, Risinger MW, McNelis AM. Childhood epilepsy and asthma: comparison of quality of life. Epilepsia. 1994;35(3):608-15.

Miller V, Palermo TM, Grewe SD. Quality of life in pediatric epilepsy: demographic and disease-related predictors and comparison with healthy controls. Epilepsy & behavior. 2003;4(1):36-42.

Otero S. Psychopathology and psychological adjustment in children and adolescents with epilepsy. World Journal of Pediatrics. 2009;5(1):12-7.

Carpay HA, Vermeulen J, Stroink H, FBrouwer O, Peters A, Donselaar CA. Disability due to restrictions in childhood epilepsy. Developmental Medicine & Child Neurology. 1997;39(8):521-6.

Sillanpää M. Learning disability: occurrence and long-term consequences in childhood-onset epilepsy. Epilepsy & behavior. 2004;5(6):937-44.

Austin JK, Huberty TJ, Huster GA, Dunn DW. Academic achievement in children with epilepsy or asthma. Developmental Medicine & Child Neurology. 1998;40(4):248-55.

Andelman F. Analysis of quality of life among adolescents with epilepsy. International journal of adolescent medicine and health. 2000;12(Supplement):17-24.

Fayed N, De Camargo OK, Kerr E, Rosenbaum P, Dubey A, Bostan C, et al. Generic patient‐reported outcomes in child health research: a review of conceptual content using World Health Organization definitions. Developmental Medicine & Child Neurology. 2012;54(12):1085-95.

Al-Khateeb JM, Al-Khateeb AJ. Research on psychosocial aspects of epilepsy in Arab countries: A review of literature. Epilepsy & behavior. 2014;31:256-62.

Rajabi F, Dabiran S, Hatmi ZN, Zamani G. Quality of life of Epileptic Patients Compared to General. Acta Medica Iranica. 2009;47(1):75-8.

Ravens-Sieberer U, Auquier P, Erhart M, Gosch A, Rajmil L, Bruil J, et al. The KIDSCREEN-27 quality of life measure for children and adolescents: psychometric results from a cross-cultural survey in 13 European countries. Quality of Life Research. 2007;16(8):1347-56.

Jafari P, Bagheri Z, Safe M. Item and response-category functioning of the Persian version of the KIDSCREEN-27: Rasch partial credit model. Health Qual Life Outcomes. 2012;10:127.

Nik-Azin A, Naeinian M, Shairi MR. Validity and Reliability of Health Related Quality of Life Questionnaire "KIDSCREEN-27" in a Sample of Iranian Students. Iranian Journal of Psychiatry and Clinical Psychology. 2012;18(4):310-21.

Khan S, Al Semari AA. Epilepsy: A Comprehensive Textbook 2nd Edition.

Fayed N, Davis AM, Streiner DL, Rosenbaum PL, Cunningham CE, Lach LM, et al. Children's perspective of quality of life in epilepsy. Neurology. 2015;84(18):1830-7.

Arya V, Gehlawat VK, Kaushik JS, Gathwala G. Assessment of parent reported quality of life in children with epilepsy from Northern India: A cross-sectional study. Journal of pediatric neurosciences. 2014;9(1):17.

Westbrook LE, Bauman LJ, Shinnar S. Applying stigma theory to epilepsy: a test of a conceptual model. Journal of Pediatric Psychology. 1992;17(5):633-49.

Asato MR, Manjunath R, Sheth RD, Phelps SJ, Wheless JW, Hovinga CA, et al. Adolescent and caregiver experiences with epilepsy. Journal of child neurology. 2009;24(5):562-71.

Luoni C, Bisulli F, Canevini MP, De Sarro G, Fattore C, Galimberti CA, et al. Determinants of health‐related quality of life in pharmacoresistant epilepsy: Results from a large multicenter study of consecutively enrolled patients using validated quantitative assessments. Epilepsia. 2011;52(12):2181-91.

Austin JK, Huster GA, Dunn DW, Risinger MW. Adolescents with active or inactive epilepsy or asthma: a comparison of quality of life. Epilepsia. 1996;37(12):1228-38.

Räty LK, Larsson BMW, Söderfeldt BA. Health-related quality of life in youth: a comparison between adolescents and young adults with uncomplicated epilepsy and healthy controls. Journal of Adolescent Health. 2003;33(4):252-8.

Ferro MA. Risk factors for health‐related quality of life in children with epilepsy: A meta‐analysis. Epilepsia. 2014;55(11):1722-31.

Davila-Avila NM, Delgado-De la Mora J, Candia-Plata M, Alvarez-Hernandez G. [Health-related quality of life in children with epilepsy in a Mexican hospital]. Revista de neurologia. 2014;59(2):63-70.

Suwannachote S, Wechapinan T, Sriudomkajorn S. Quality of life in adolescent absence epilepsy at Queen Sirikit National Institute of Child Health. Journal of the Medical Association of Thailand= Chotmaihet thangphaet. 2014;97:S120-5.

Ronen GM, Streiner DL, Rosenbaum P. Health‐related Quality of Life in Children with Epilepsy: Development and Validation of Self‐report and Parent Proxy Measures. Epilepsia. 2003;44(4):598-612.

Taylor J, Jacoby A, Baker GA, Marson AG. Self‐reported and parent‐reported quality of life of children and adolescents with new‐onset epilepsy. Epilepsia. 2011;52(8):1489-98.

DOI: https://doi.org/10.22037/ijcn.v14i2.3863


  • There are currently no refbacks.

Copyright (c) 2020 Iranian Journal of Child Neurology