Protein interaction mapping related to Becker Muscular Dystrophy
Iranian Journal of Child Neurology,
Vol. 13 No. 2 (2019),
4 Esfand 2019
,
Page 125-134
https://doi.org/10.22037/ijcn.v13i2.18288
Abstract
Objective
Becker Muscular Dystrophy (BMD) is a neuromuscular disorder which is incurable. In this research protein interaction network of most associated proteins with Becker muscular dystrophy to provide a better clarification of disorder underlying mechanism is investigated.
Materials & Methods
The related genes to BMD were retrieved via string data base and conducted by Cytoscape and the related algorithms. The network centrality analysis was performed based on degree, betweennes, closeness and stress parameters. Gene ontology and clustering were performed via ClueGO analysis.
Results
The results indicate that DMD as the super-hub as well as other central proteins including UTRN, TTN, DNM2 and RYR1 are important in BMD in terms of interaction features. The impairment of muscular contraction may be vital in BMD disease pathogenesis as it is the highlighted biological process term obtained by ClueGO analysis.
Conclusion
It is possible that DMD targeting may be the main concern for dystrophy clinical approaches. However the other suggested proteins should be evaluated.
In conclusion, targeting these key proteins are required for treatment goals following extensive validation studies.
- Becker Muscular Dystrophy (BMD)
- Protein-protein interaction
- Map analysis
- Gene ontology
- Hub proteins
How to Cite
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