Mandibular premolars have earned a reputation for having aberrant anatomy. The occurrence of three canals with three separate foramina in mandibular premolars is very rare. If predictable treatment of a three rooted mandibular premolar is planned, precise knowledge of clinical and radiographic anatomy is absolutely necessary. These teeth may also require special shaping and obturating techniques. This article reports and discusses the treatment recommendations for an unusual occurrence of three canals with three separate foramina in a second mandibular premolar.