Evaluation of the Frequency of MLH-1 Loss in Serrated Polyps of Colon, A Single Center Study from South of Iran.

Bita Geramizadeh, Nooshin Dindar, Samirasadat Hasheminasab, Tahere Haeidari

Abstract


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Aim: Evaluation of the role of MLH-1 loss in serrated polyps of colon in a population of South of Iran.

Background: There has been extensive change in classification and pathogenesis of serrated polyps of the colon during the last 10 years. The new classification is mostly based on the knowledge of the molecular pathogenesis and the rate of progression to colorectal cancer in these types of polyps. One of the most common and early lesions in molecular pathogenesis of serrated colorectal cancer is loss of MLH-1.

Patients and methods: In this study over 2 years (2012-13), 78 cases of colorectal polyps with serrated morphology resected in hospitals affiliated with Shiraz University of Medical Sciences were reclassified and investigated for MLH-1 loss by immunohistochemical method.

Results: Out of the 78 colorectal polyps, 64 were classified as hyperplastic polyp (HP) and 14 as sessile serrated adenoma/polyp (SSA/P). There was no case of traditional serrated adenoma. Three cases of SSA/P located in right colon showed dysplasia. MLH-1 loss was detected only in these 3 cases. No case of HP or SSA/P without dysplasia showed MLH-1 loss.

Conclusion: SSA/P is not a common serrated polyp in our population, i.e. it is much less common than HP. Although MLH-1 loss in serrated polyps of colon is overall rare, it is fairly common in dysplastic right sided SSA/P, which confirms this molecular change as an early event in serrated carcinogenesis.


Keywords


hyperplastic polyp, Sessile serrated adenoma, MLH-1 loss?

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References


Barret M, Terris B, Dhooge M, Dreanic J, Prat F, Coriat R, Chaussade S. Sessile serrated adenoma: From identification to resection. Digestive and Liver Disease 2015; 47: 95–102.

Ensari A, Bilezikçi B, Carneiro F, Doğusoy GB, Driessen A, Dursun A& et al. Serrated polyps of the colon: how reproducible is their classification? Virchows Arch 2012; 461:495–504

Kim KM, Lee EJ, Ha S, Kang SY, Jang KT, Park CK, et al. Molecular Features of colorectak hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol 2011; 35:1274-1286

Young J, Jass JR. The Case for a Genetic predisposition to serrated neoplasia in the colorectum: Hypothesis and review of the literature. Cancer Epidemiol Biomarkers Prev 2006’15”1778-84

Snover DC, Ahnen DJ, Burt RW, Odze RD (2010) Serrated polyps of the colon and rectum and serrated polyposis. In: Bosman FT, Carneiro F, Hruban RH, Theise ND (eds) WHO classification of tumours of the digestive system, 4th edn. IARC, Lyon, pp 160–165

Geramizadeh B. Molecular Biomarkers of Colorectal Cancer: A Review of Published Articles From Iran. Ann Colorectal Res.

;3: 1-5

Bateman AC. Pathology of serrated colorectal lesions. J Clin Pathol 2014;67: 865–874

O’Brian MJ, Yang S, Mack C, Xu H, Huang CS, Mulcahy E, et al.Comparison of microsatellite instability, CpG island methylation phenotype, BRAF and KRAS status in serrated polyps and traditional adenomas indicates separate pathways to distinct colorectal carcinoma end points. Am J Surg Pathol 2006; 30: 1491–1501

Young J, Jass JR. The Case for a Genetic predisposition to serrated neoplasia in the colorectum: Hypothesis and review of the literature. Cancer Epidemiol Biomarkers Prev 2006;15:1778–84

Geramizadeh B, Keshtkar-Jahromi M. Pathology of Colorectal Polyps: A Study from South of Iran. . A nnals of Colorectal Research. 2013; 1: 60-2.

Delavari A, Mardan F, Salimzadeh H, Bishesari F, Khosravi P, Khanezad M, et al. Characteristics of Colorectal Polyps and Cancer; a Retrospective Review of Colonoscopy Data in Iran. Middle East Journal of Digestive Diseases 2014; 6: 144-150

Molaei M, Yadollahzadeh M, Almasi S, Shivarani S, Fatemi SR, Zali MR. Sporadic colorectal polyps and mismatch repair proteins. 2011;54: 725-29

Kim YH, Kakar S, Cun L, Deng G, Kim YS. Distinct CpG island methylation profiles and BRAF mutation status in serrated and adenomatous colorectal polyps. Int. J. Cancer 2008; 123: 2587–2593

Kim KM, Lee EJ, Ha S, Young Kang S, Jang KT, Park CK. Molecular features of colorectal hyperplastic polyps and sessile serrated adenoma/polyps from Korea. Am J Surg Pathol 2011;35:1274–1286

Sandmeier D, Benhattar J, Martin P, Bouzourenen H. Serrated polyps of the large intestine: a molecular study comparing sessile serrated adenomas and hyperplastic polyps. Histopathology 2009; 55: 206–213.




DOI: http://dx.doi.org/10.22037/ghfbb.v0i0.925

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GHFBB by Gastroenterology and Liver Diseases Research Institute is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

 

PISSN: 2008-2258

EISSN: 2008-4234


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