Effect of vitamin D3 supplementation on TNF-? serum level and disease activity index in Iranian IBD patients
Gastroenterology and Hepatology from Bed to Bench,
Vol. 8 No. 1 (2015),
4 January 2015
,
Page 33-41
https://doi.org/10.22037/ghfbb.v1i1.604
Abstract
Background and aim: Vitamin D has immune-regulatory functions in experimental inflammatory bowel disease (IBD) and vitamin D deficiency is common in IBD patients. The aim of the study was to assess the effectiveness of vitamin D3 [1,25(OH)2D3] treatment in IBD with regard to tumor necrosis factor-alpha (TNF-?) serum level and clinical disease activity index (CDAI).
Materials and methods: This was a double blind randomized clinical trial on 108 IBD patients with serum 25-OHD level less than 30ng/ml, whom divided into vitamin D and control groups. Vitamin D group received 50000 IU vitamin D3 for 12 weeks. Before and after the study, TNF-? and 25-OHD serum levels were measured by ELISA method. Data were analyzed using paired t test, chi-square test and Spearman correlation coefficient. P values ??less than 0.05 were considered statistically significant.
Results: Before the intervention no significant difference was found between baseline characteristics and TNF-? serum level of two groups. After intervention TNF-? serum level reduced but this reduction was not statistically significant (P= 0.07, 95% CI: -0.45 to 8.14). The mean serum 25-OHD level of vitamin D increased from 15.54 to 67.89, which was statistically significant (P= 0.00, 95% CI: -61.40 to -43.30). TNF-? level was also associated significantly with CDAI before (Spearman’s rho: 0.3, P<0.0001) and after (Spearman’s rho: 0.27, P=0.01) intervention.
Conclusion: Oral supplementation vitamin D3 significantly increased serum vitamin D levels and insignificantly reduced serum TNF-? level. More studies with larger samples would be beneficial to assess vitamin D3 supplementation efficient effect in IBD.
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